BE902586A - COMPOUNDS WITH ANTIBACTERIAL ACTIVITY, THEIR MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME. - Google Patents

COMPOUNDS WITH ANTIBACTERIAL ACTIVITY, THEIR MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME.

Info

Publication number
BE902586A
BE902586A BE0/215132A BE215132A BE902586A BE 902586 A BE902586 A BE 902586A BE 0/215132 A BE0/215132 A BE 0/215132A BE 215132 A BE215132 A BE 215132A BE 902586 A BE902586 A BE 902586A
Authority
BE
Belgium
Prior art keywords
compounds
group
manufacturing
same
pharmaceutical compositions
Prior art date
Application number
BE0/215132A
Other languages
French (fr)
Inventor
F Villani
A Renzetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BE902586A publication Critical patent/BE902586A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composés répondant à la formule générale (1) : dans laquelle R représante un groupe alcoxyalkyle, alcanoyloxyalkyle, aroyloxyalkyle, alcoxycarbonyloxyalkyle, alcoxycarbonyle, aralkyloxycarbonyle, ou un groupe hétérocycle, monocyclique ou bicylique, substitué éventuellement à son tour par un groupe alkyle C1-C4 ou des groupes oxo, les groupes alkyle, alcoxy et alcanoyle cités ci-dessus pouvant etre linéaires ou ramifiés et contenant de 1 à 5 atomes de carbone; et R1 représente l'hydrogène ou un groupe alkyle inférieur, de préférence le méthyle, ainsi que leurs hydrates ou leurs sels d'addition avec des acides inorganiques ou organiques, acceptables du point de vue pharmaceutique, et les éventuels énantiomères et/ou diastéréoisomères. Ces composés présentent un spectre d'activité et antibactérienne une puissance supérieure, mais avec une faible absorption.Compounds corresponding to the general formula (1): in which R represents an alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarbonyloxyalkyl, alkoxycarbonyl, aralkyloxycarbonyl group, or a heterocycle, monocyclic or bicylic group, optionally substituted in turn by a C1-C4 alkyl group or oxo groups, the alkyl, alkoxy and alkanoyl groups mentioned above possibly being linear or branched and containing from 1 to 5 carbon atoms; and R1 represents hydrogen or a lower alkyl group, preferably methyl, as well as their hydrates or their addition salts with inorganic or organic acids, acceptable from the pharmaceutical point of view, and the optional enantiomers and / or diastereoisomers. These compounds have a higher potency and antibacterial spectrum, but with low absorption.

BE0/215132A 1984-06-04 1985-06-04 COMPOUNDS WITH ANTIBACTERIAL ACTIVITY, THEIR MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME. BE902586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8421241A IT1213173B (en) 1984-06-04 1984-06-04 ANTIBACTERIAL ACTIVITY COMPOUNDS, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS.

Publications (1)

Publication Number Publication Date
BE902586A true BE902586A (en) 1985-09-30

Family

ID=11178899

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215132A BE902586A (en) 1984-06-04 1985-06-04 COMPOUNDS WITH ANTIBACTERIAL ACTIVITY, THEIR MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME.

Country Status (7)

Country Link
KR (1) KR870000286B1 (en)
BE (1) BE902586A (en)
CH (1) CH666264A5 (en)
ES (1) ES8604193A1 (en)
GB (1) GB2160519B (en)
IT (1) IT1213173B (en)
PT (1) PT80590B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525108A1 (en) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen ANTIBACTERIAL EFFECT OF CHINOLON CARBON ACID ESTERS
DE3601566A1 (en) * 1986-01-21 1987-07-23 Bayer Ag PHARMACEUTICAL PREPARATIONS OF CIPROFLOXACIN
US5286754A (en) * 1986-01-21 1994-02-15 Bayer Aktiengesellschaft Pharmaceutical formulations of ciprofloxacin
FR2594439B1 (en) * 1986-02-19 1989-04-21 Vetoquinol Sa NOVEL ESTER, THIOESTER AND QUINOLONE AMIDE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5066800A (en) * 1990-04-27 1991-11-19 Hoffmann-La Roche Inc. Qunoline intermediates useful therein for synthesizing antibacterial compounds
ES2050594B1 (en) * 1991-12-31 1994-12-16 Ind Quimica Agropecuaria S A PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.
ES2048110B1 (en) * 1992-07-22 1995-02-01 Prodesfarma Sa PROCEDURE FOR THE PREPARATION OF 2,2-DIOXIDES OF PIRAZINO (2,3-C) -1,2,6-TIADIAZINA N (1) SUBSTITUTED.
DE502005009170D1 (en) * 2004-06-24 2010-04-22 Bayer Materialscience Ag Thermostabilized polycarbonate compositions
CN109942488A (en) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 A kind of quinoline carboxylic acid ester's compound and preparation method thereof and purposes

Also Published As

Publication number Publication date
GB2160519A (en) 1985-12-24
IT1213173B (en) 1989-12-14
GB2160519B (en) 1988-07-20
PT80590B (en) 1987-04-21
KR860000282A (en) 1986-01-27
KR870000286B1 (en) 1987-02-25
ES8604193A1 (en) 1986-01-16
ES543820A0 (en) 1986-01-16
PT80590A (en) 1985-07-01
GB8513962D0 (en) 1985-07-03
IT8421241A0 (en) 1984-06-04
CH666264A5 (en) 1988-07-15

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: CHIESI FARMACEUTICI S.P.A.

Effective date: 19890630