BE899007A - NOVEL ISOXAZOLES AND PROCESS FOR THEIR PREPARATION - Google Patents
NOVEL ISOXAZOLES AND PROCESS FOR THEIR PREPARATIONInfo
- Publication number
- BE899007A BE899007A BE1/10966A BE1010966A BE899007A BE 899007 A BE899007 A BE 899007A BE 1/10966 A BE1/10966 A BE 1/10966A BE 1010966 A BE1010966 A BE 1010966A BE 899007 A BE899007 A BE 899007A
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- isoxazoles
- novel
- novel isoxazoles
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 abstract 1
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000002545 isoxazoles Chemical class 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procédé de préparation de nouveaux dérivés isoxazoles de formule générale (I) dans laquelle on fait réagir des composés de formules (II) et/ou (IIa) avec une base forte pour obtenir un composé contenant, comme substituants, un groupe nitrile ou un groupe carboxyle. Application pour la préparation de la thiénamycine.Process for the preparation of new isoxazole derivatives of general formula (I) in which compounds of formulas (II) and / or (IIa) are reacted with a strong base to obtain a compound containing, as substituents, a nitrile group or a group carboxyl. Application for the preparation of thienamycin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU83661A HU189236B (en) | 1983-02-28 | 1983-02-28 | Process for producing new type isoxazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
BE899007A true BE899007A (en) | 1984-08-27 |
Family
ID=10950718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE1/10966A BE899007A (en) | 1983-02-28 | 1984-02-27 | NOVEL ISOXAZOLES AND PROCESS FOR THEIR PREPARATION |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS59164784A (en) |
BE (1) | BE899007A (en) |
CH (1) | CH658655A5 (en) |
DE (1) | DE3405422A1 (en) |
ES (3) | ES8601935A1 (en) |
FR (1) | FR2541678A1 (en) |
GB (1) | GB2135996B (en) |
HU (1) | HU189236B (en) |
IT (1) | IT1174498B (en) |
NL (1) | NL8400575A (en) |
PT (1) | PT78157B (en) |
SE (1) | SE8401064L (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5366987A (en) * | 1991-08-22 | 1994-11-22 | Warner-Lambert Company | Isoxazolyl-substituted alkyl amide ACAT inhibitors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163057A (en) * | 1977-12-27 | 1979-07-31 | Sandoz, Inc. | Isoxazole-4-carboxamides as tranquilizers, sleep-inducers and muscle relaxants |
-
1983
- 1983-02-28 HU HU83661A patent/HU189236B/en not_active IP Right Cessation
-
1984
- 1984-02-15 DE DE19843405422 patent/DE3405422A1/en not_active Withdrawn
- 1984-02-24 NL NL8400575A patent/NL8400575A/en not_active Application Discontinuation
- 1984-02-27 SE SE8401064A patent/SE8401064L/en not_active Application Discontinuation
- 1984-02-27 IT IT19806/84A patent/IT1174498B/en active
- 1984-02-27 PT PT78157A patent/PT78157B/en unknown
- 1984-02-27 JP JP59034477A patent/JPS59164784A/en active Pending
- 1984-02-27 GB GB08405001A patent/GB2135996B/en not_active Expired
- 1984-02-27 FR FR8402947A patent/FR2541678A1/en active Pending
- 1984-02-27 CH CH935/84A patent/CH658655A5/en not_active IP Right Cessation
- 1984-02-27 BE BE1/10966A patent/BE899007A/en not_active IP Right Cessation
- 1984-02-28 ES ES530121A patent/ES8601935A1/en not_active Expired
-
1985
- 1985-06-14 ES ES544191A patent/ES8604174A1/en not_active Expired
- 1985-06-14 ES ES544192A patent/ES8604175A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3405422A1 (en) | 1984-08-30 |
GB2135996B (en) | 1986-09-10 |
JPS59164784A (en) | 1984-09-17 |
NL8400575A (en) | 1984-09-17 |
ES544192A0 (en) | 1986-01-16 |
ES8604174A1 (en) | 1986-01-16 |
GB2135996A (en) | 1984-09-12 |
SE8401064D0 (en) | 1984-02-27 |
PT78157B (en) | 1986-05-19 |
SE8401064L (en) | 1984-08-29 |
GB8405001D0 (en) | 1984-04-04 |
IT1174498B (en) | 1987-07-01 |
ES530121A0 (en) | 1985-11-16 |
ES8604175A1 (en) | 1986-01-16 |
ES544191A0 (en) | 1986-01-16 |
FR2541678A1 (en) | 1984-08-31 |
CH658655A5 (en) | 1986-11-28 |
HU189236B (en) | 1986-06-30 |
PT78157A (en) | 1984-03-01 |
IT8419806A0 (en) | 1984-02-27 |
ES8601935A1 (en) | 1985-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: BIOGAL GYOGYSZERGYAR Effective date: 19890228 Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T. Effective date: 19890228 |