BE862097A - Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants - Google Patents

Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants

Info

Publication number
BE862097A
BE862097A BE183659A BE183659A BE862097A BE 862097 A BE862097 A BE 862097A BE 183659 A BE183659 A BE 183659A BE 183659 A BE183659 A BE 183659A BE 862097 A BE862097 A BE 862097A
Authority
BE
Belgium
Prior art keywords
hypolipemiants
hypocholesterolemiants
benzothiophens
preparation
new
Prior art date
Application number
BE183659A
Other languages
English (en)
Original Assignee
Parcor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT958776A external-priority patent/AT345814B/de
Priority claimed from AT652777A external-priority patent/ATA652777A/de
Application filed by Parcor filed Critical Parcor
Publication of BE862097A publication Critical patent/BE862097A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
BE183659A 1976-12-23 1977-12-21 Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants BE862097A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT958776A AT345814B (de) 1976-12-23 1976-12-23 Verfahren zur herstellung von neuen n- substituierten 2-phenyl-benzo(b)thiophen-3-amin-derivaten und ihren salzen
AT652877 1977-09-12
AT652777A ATA652777A (de) 1977-09-12 1977-09-12 Verfahren zur herstellung von neuen n,n- -disubstituierten 2-phenyl-benzo(b)thiophen-3- -amin-derivaten und ihren salzen

Publications (1)

Publication Number Publication Date
BE862097A true BE862097A (fr) 1978-06-21

Family

ID=27150647

Family Applications (1)

Application Number Title Priority Date Filing Date
BE183659A BE862097A (fr) 1976-12-23 1977-12-21 Nouveaux benzothiophenes, leurs procedes de preparation et leur application notamment comme hypolipemiants et hypocholesterolemiants

Country Status (16)

Country Link
US (1) US4157399A (fr)
JP (1) JPS5384962A (fr)
AR (1) AR217095A1 (fr)
AU (1) AU511826B2 (fr)
BE (1) BE862097A (fr)
CA (1) CA1120934A (fr)
CH (1) CH633552A5 (fr)
DE (1) DE2757422A1 (fr)
ES (1) ES465233A1 (fr)
FR (1) FR2375228A1 (fr)
GB (1) GB1586486A (fr)
IE (1) IE46097B1 (fr)
LU (1) LU78739A1 (fr)
NL (1) NL7714235A (fr)
NZ (1) NZ185880A (fr)
SE (1) SE433213B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3637223A1 (de) * 1986-11-03 1988-05-05 Bayer Ag Verfahren zur herstellung von thiophenverbindungen
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
CA2214919A1 (fr) * 1996-09-24 1998-03-24 Kenneth Lee Hauser Composes de benzothiophene, intermediaires, procedes, compositions et methodes
WO2002018364A2 (fr) * 2000-08-25 2002-03-07 Eli Lilly And Company Procedes permettant la preparation de 2-phenyl-3-aminobenzothiophenes
US20040044224A1 (en) * 2001-08-21 2004-03-04 Conrad Preston Charles Process for preparing 2-phenyl-3-aminobenzothiophenes
CN100562516C (zh) * 2001-12-27 2009-11-25 第一制药株式会社 β-淀粉样蛋白产生和分泌的抑制剂
EP1640366A4 (fr) * 2003-06-30 2009-05-13 Daiichi Seiyaku Co Derive de methyle sulfone heterocyclique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT316543B (de) * 1972-08-21 1974-07-10 Sauter Dr Fritz Verfahren zur Herstellung von neuen, basisch substituierten 2-Phenyl-2-3-dihydro-benzo[b]-thiophen-1,1-dioxyd-Derivaten und ihren Salzen

Also Published As

Publication number Publication date
SE433213B (sv) 1984-05-14
DE2757422A1 (de) 1978-06-29
GB1586486A (en) 1981-03-18
NL7714235A (nl) 1978-06-27
IE46097L (en) 1978-06-23
LU78739A1 (fr) 1978-04-17
SE7714663L (sv) 1978-06-24
AU3181077A (en) 1979-06-28
CA1120934A (fr) 1982-03-30
JPS5384962A (en) 1978-07-26
ES465233A1 (es) 1979-06-01
NZ185880A (en) 1979-12-11
AU511826B2 (en) 1980-09-04
FR2375228B1 (fr) 1981-01-16
IE46097B1 (en) 1983-02-23
US4157399A (en) 1979-06-05
CH633552A5 (fr) 1982-12-15
AR217095A1 (es) 1980-02-29
FR2375228A1 (fr) 1978-07-21

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: PARCOR

Effective date: 19841221