BE850723A - Phenyl-amidines substituees - Google Patents
Phenyl-amidines substitueesInfo
- Publication number
- BE850723A BE850723A BE174356A BE174356A BE850723A BE 850723 A BE850723 A BE 850723A BE 174356 A BE174356 A BE 174356A BE 174356 A BE174356 A BE 174356A BE 850723 A BE850723 A BE 850723A
- Authority
- BE
- Belgium
- Prior art keywords
- amidines
- substituted phenyl
- phenyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2895/76A GB1538097A (en) | 1976-01-26 | 1976-01-26 | Substituted phenyl-amidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE850723A true BE850723A (fr) | 1977-05-16 |
Family
ID=9748048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE174356A BE850723A (fr) | 1976-01-26 | 1977-01-25 | Phenyl-amidines substituees |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4146647A (cs) |
| JP (1) | JPS5953895B2 (cs) |
| BE (1) | BE850723A (cs) |
| CA (1) | CA1074797A (cs) |
| CH (1) | CH620901A5 (cs) |
| DE (1) | DE2702119C2 (cs) |
| DK (1) | DK30277A (cs) |
| ES (1) | ES455294A1 (cs) |
| FR (1) | FR2338927A1 (cs) |
| GB (1) | GB1538097A (cs) |
| IE (1) | IE44416B1 (cs) |
| LU (1) | LU76641A1 (cs) |
| NL (1) | NL188573C (cs) |
| SE (1) | SE440501B (cs) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH630606A5 (en) * | 1977-02-15 | 1982-06-30 | Lafon Labor | Phenylamidine derivatives useful especially in therapeutics |
| EP0011596B1 (de) * | 1978-10-09 | 1981-12-30 | Ciba-Geigy Ag | Neue 2-(alpha-Phenoxy-alkyl)-imidazoline und ihre Salze, deren Herstellung und Verwendung sowie sie enthaltende Mittel zur Bekämpfung von pflanzenschädlichen und tierparasitären Milben |
| EP0024747B1 (de) * | 1978-11-03 | 1983-05-11 | Bayer Ag | Anilinomethyloxim-ether und Verfahren zu ihrer Herstellung |
| US4260626A (en) * | 1979-03-26 | 1981-04-07 | Richardson-Merrell Inc. | Tetrahydro and imidazoline antisecretory compounds |
| US4616085A (en) * | 1980-06-19 | 1986-10-07 | Petrolite Corporation | Thioethers of imidazolines |
| FR2506764A1 (fr) * | 1981-05-26 | 1982-12-03 | Synthelabo | Derives d'amidoximes, leur preparation et leur application en therapeutique |
| US5227484A (en) * | 1982-01-14 | 1993-07-13 | Merck Patent Gmbh | Anisotropic compounds having nematic phase and liquid crystal mixtures |
| FR2549049B1 (fr) * | 1983-07-13 | 1986-06-20 | Chauvin Blache Lab | Nouvelles amidines, leur procede de preparation et leur application therapeutique |
| US4659363A (en) * | 1983-07-25 | 1987-04-21 | Ciba-Geigy Corporation | N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof |
| GB9509930D0 (en) * | 1995-05-17 | 1995-07-12 | Smithkline Beecham Corp | Method for preparing certain acetonitriles |
| JP2009524617A (ja) * | 2006-01-27 | 2009-07-02 | エフ．ホフマン−ラ ロシュ アーゲー | 置換２−イミダゾール又はイミダゾリン誘導体の使用 |
| ATE462696T1 (de) * | 2006-10-19 | 2010-04-15 | Hoffmann La Roche | Aminomethyl-2-imidazole mit affinität zu mit dem trace-amin assoziierten rezeptoren |
| RU2009112496A (ru) * | 2006-10-19 | 2010-11-27 | Ф. Хоффманн-Ля Рош Аг (Ch) | Аминометил-4-имидазолы |
| ATE533755T1 (de) * | 2006-11-02 | 2011-12-15 | Hoffmann La Roche | Substituierte 2-imidazole als modulatoren der mit spurenaminen assoziierten rezeptoren |
| CN101535298A (zh) * | 2006-11-16 | 2009-09-16 | 弗·哈夫曼-拉罗切有限公司 | 取代的4-咪唑类化合物 |
| ES2364701T3 (es) * | 2006-12-13 | 2011-09-12 | F. Hoffmann-La Roche Ag | Nuevos 2-imidazoles como ligandos para receptores asociados a aminas trazas. |
| US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| BRPI0806940A2 (pt) * | 2007-02-02 | 2014-05-06 | Hoffmann La Roche | 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc |
| RU2460725C2 (ru) * | 2007-02-15 | 2012-09-10 | Ф. Хоффманн-Ля Рош Аг | Новые 2-аминооксазолины в качестве лигандов taar1 |
| EP2173720A2 (en) | 2007-07-02 | 2010-04-14 | F. Hoffmann-Roche AG | 2-imidazolines having a good affinity to the trace amine associated receptors (taars) |
| JP2010531836A (ja) * | 2007-07-03 | 2010-09-30 | エフ．ホフマン−ラ ロシュ アーゲー | ４−イミダゾリン及びそれらの抗うつ剤としての使用 |
| JP2010534701A (ja) * | 2007-07-27 | 2010-11-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒリガンドとしての２−アゼチジンメタンアミン及び２−ピロリジンメタンアミン |
| AU2008281877A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of CNS disorders |
| JP5341084B2 (ja) * | 2007-08-03 | 2013-11-13 | エフ．ホフマン−ラ ロシュ アーゲー | Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体 |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| JP5547187B2 (ja) * | 2008-07-24 | 2014-07-09 | エフ．ホフマン−ラ ロシュ アーゲー | ４，５−ジヒドロ−オキサゾール−２−イル誘導体 |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| EP3430010B1 (en) | 2016-03-17 | 2020-07-15 | H. Hoffnabb-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL259617A (cs) * | 1960-01-01 | |||
| US3115525A (en) * | 1960-04-21 | 1963-12-24 | Wassermann S P A Soc It Per Sp | Halogen-substituted amidoximes |
| US3394181A (en) * | 1964-06-29 | 1968-07-23 | Sterling Drug Inc | Phenoxy-lower-alkyl-amidoximes and phenylamino-lower-alkyl-amidoximes |
| US3445517A (en) * | 1966-06-03 | 1969-05-20 | Lilly Co Eli | Aryl acetamidines |
| FR2036958A6 (cs) * | 1969-04-23 | 1970-12-31 | Orsymonde | |
| FR2149264B1 (cs) * | 1971-08-13 | 1974-09-06 | Orsymonde | |
| US3775478A (en) * | 1972-05-30 | 1973-11-27 | Dow Chemical Co | Substituted phenylthioamidines |
| FR2207706B1 (cs) * | 1972-11-24 | 1975-11-28 | Orsymonde | |
| US3939912A (en) * | 1975-03-21 | 1976-02-24 | Continental Oil Company | Method for reducing the production of water from oil wells |
-
1976
- 1976-01-26 GB GB2895/76A patent/GB1538097A/en not_active Expired
-
1977
- 1977-01-11 CH CH27377A patent/CH620901A5/fr not_active IP Right Cessation
- 1977-01-20 DE DE2702119A patent/DE2702119C2/de not_active Expired
- 1977-01-20 FR FR7701595A patent/FR2338927A1/fr active Granted
- 1977-01-20 IE IE110/77A patent/IE44416B1/en not_active IP Right Cessation
- 1977-01-24 CA CA270,277A patent/CA1074797A/en not_active Expired
- 1977-01-24 ES ES455294A patent/ES455294A1/es not_active Expired
- 1977-01-25 BE BE174356A patent/BE850723A/xx not_active IP Right Cessation
- 1977-01-25 DK DK30277A patent/DK30277A/da not_active Application Discontinuation
- 1977-01-25 LU LU76641A patent/LU76641A1/xx unknown
- 1977-01-25 SE SE7700777A patent/SE440501B/xx not_active IP Right Cessation
- 1977-01-25 US US05/762,774 patent/US4146647A/en not_active Expired - Lifetime
- 1977-01-26 NL NLAANVRAGE7700806,A patent/NL188573C/xx not_active IP Right Cessation
- 1977-01-26 JP JP52007602A patent/JPS5953895B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1074797A (en) | 1980-04-01 |
| NL7700806A (nl) | 1977-07-28 |
| SE7700777L (sv) | 1977-07-27 |
| JPS52105131A (en) | 1977-09-03 |
| IE44416L (en) | 1977-07-26 |
| DE2702119C2 (de) | 1986-07-10 |
| DE2702119A1 (de) | 1977-07-28 |
| US4146647A (en) | 1979-03-27 |
| FR2338927B1 (cs) | 1980-10-10 |
| GB1538097A (en) | 1979-01-10 |
| DK30277A (da) | 1977-07-27 |
| NL188573C (nl) | 1992-08-03 |
| CH620901A5 (cs) | 1980-12-31 |
| JPS5953895B2 (ja) | 1984-12-27 |
| SE440501B (sv) | 1985-08-05 |
| FR2338927A1 (fr) | 1977-08-19 |
| ES455294A1 (es) | 1978-01-01 |
| IE44416B1 (en) | 1981-11-18 |
| LU76641A1 (cs) | 1977-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: LABORATOIRE L. LAFON Effective date: 19930131 |