BE811324A - Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents - Google Patents
Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agentsInfo
- Publication number
- BE811324A BE811324A BE141173A BE141173A BE811324A BE 811324 A BE811324 A BE 811324A BE 141173 A BE141173 A BE 141173A BE 141173 A BE141173 A BE 141173A BE 811324 A BE811324 A BE 811324A
- Authority
- BE
- Belgium
- Prior art keywords
- alkyl
- dihydropyridine
- carboxylates
- dialkyl
- aryl
- Prior art date
Links
- 125000004103 aminoalkyl group Chemical group 0.000 title 1
- 150000007942 carboxylates Chemical class 0.000 title 1
- 230000002490 cerebral effect Effects 0.000 title 1
- 239000000812 cholinergic antagonist Substances 0.000 title 1
- 230000003170 musculotropic effect Effects 0.000 title 1
- 229940124549 vasodilator Drugs 0.000 title 1
- 239000003071 vasodilator agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- ZETIVVHRRQLWFW-UHFFFAOYSA-N 3-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC(C=O)=C1 ZETIVVHRRQLWFW-UHFFFAOYSA-N 0.000 abstract 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 benzyl-N-methylamino Chemical group 0.000 abstract 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- YCKAGGHNUHZKCL-XQRVVYSFSA-N propan-2-yl (z)-3-aminobut-2-enoate Chemical compound CC(C)OC(=O)\C=C(\C)N YCKAGGHNUHZKCL-XQRVVYSFSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP48020423A JPS5930704B2 (ja) | 1973-02-20 | 1973-02-20 | 新規１，４−ジヒドロピリジン誘導体の製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE811324A true BE811324A (en) | 1974-06-17 |
Family
ID=12026610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE141173A BE811324A (en) | 1973-02-20 | 1974-02-20 | Amino alkyl 2,6-dialkyl-4-aryl-1,4 dihydropyridine-3, carboxylates - useful as cerebral vasodilators and musculotropic spasmolytic agents |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5930704B2 (enrdf_load_stackoverflow) |
| BE (1) | BE811324A (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58159462A (ja) * | 1982-03-17 | 1983-09-21 | Yoshitomi Pharmaceut Ind Ltd | １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体 |
| JPS59227859A (ja) * | 1983-06-08 | 1984-12-21 | Teijin Ltd | １，４―ジヒドロピリジン―３，５―ジカルボン酸ジエステル誘導体の製造法 |
| DK8602336A (enrdf_load_stackoverflow) * | 1985-05-21 | 1986-11-22 | ||
| JPS63208574A (ja) * | 1987-02-24 | 1988-08-30 | Sanwa Kagaku Kenkyusho Co Ltd | １，４−ジヒドロピリジン誘導体及びその塩、これらの製法並びに該化合物を有効成分とする循環器系作用薬 |
-
1973
- 1973-02-20 JP JP48020423A patent/JPS5930704B2/ja not_active Expired
-
1974
- 1974-02-20 BE BE141173A patent/BE811324A/xx active Protection Beyond IP Right Term
Also Published As
| Publication number | Publication date |
|---|---|
| JPS49108082A (enrdf_load_stackoverflow) | 1974-10-14 |
| JPS5930704B2 (ja) | 1984-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CCPA | Application for a supplementary protection certificate |
Free format text: 093C0024 |
|
| RE20 | Patent expired |
Owner name: YAMANOUCHI PHARMACEUTICAL CO. LTD Effective date: 19940220 |
|
| CCPV | Grant of a supplementary protection certificate |
Free format text: 093C0024, EXPIRES:19990220 |