BE797964R - Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Info

Publication number
BE797964R
BE797964R BE129814A BE129814A BE797964R BE 797964 R BE797964 R BE 797964R BE 129814 A BE129814 A BE 129814A BE 129814 A BE129814 A BE 129814A BE 797964 R BE797964 R BE 797964R
Authority
BE
Belgium
Prior art keywords
pyrazole
preparation
application
medicinal products
new derivatives
Prior art date
Application number
BE129814A
Other languages
English (en)
French (fr)
Inventor
D A Habeck
W J Houlihan
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE797964R publication Critical patent/BE797964R/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE129814A 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments BE797964R (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18893871A 1971-10-13 1971-10-13
US23138772A 1972-03-02 1972-03-02
US25985972A 1972-06-05 1972-06-05
US27486872A 1972-07-25 1972-07-25
US30259572A 1972-10-31 1972-10-31
US34139273A 1973-03-15 1973-03-15
US05/350,140 US3932430A (en) 1971-10-13 1973-04-11 Substituted indeno, naphtho and cyclohepta pyrazoles

Publications (1)

Publication Number Publication Date
BE797964R true BE797964R (fr) 1973-10-09

Family

ID=27569229

Family Applications (3)

Application Number Title Priority Date Filing Date
BE789948D BE789948A (fr) 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE129814A BE797964R (fr) 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE789948D BE789948A (fr) 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Country Status (6)

Country Link
US (1) US3932430A (OSRAM)
AU (1) AU4765672A (OSRAM)
BE (3) BE797964R (OSRAM)
DE (2) DE2249644A1 (OSRAM)
FR (1) FR2157852A1 (OSRAM)
NL (2) NL7213549A (OSRAM)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969527A (en) * 1975-07-28 1976-07-13 E. R. Squibb & Sons, Inc. CNS active compounds
US4173634A (en) * 1979-02-23 1979-11-06 E. R. Squibb & Sons, Inc. Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents
WO1990010623A2 (en) * 1989-03-09 1990-09-20 E.I. Du Pont De Nemours And Company Arthropodicidal tetrahydrobenzopyranopyrazoles
JPH08502958A (ja) * 1992-10-23 1996-04-02 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
AU7553198A (en) * 1997-06-12 1998-12-30 Sumitomo Pharmaceuticals Company, Limited Pyrazole derivatives
WO1999017770A1 (en) * 1997-10-06 1999-04-15 Basf Aktiengesellschaft Indeno[1,2-c]pyrazole derivatives for inhibiting tyrosine kinase activity
EP1023063B1 (en) * 1997-10-06 2003-09-10 Abbott GmbH & Co. KG INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES
EP1073435B1 (en) * 1998-04-30 2004-07-07 Abbott GmbH & Co. KG Substituted tricyclic pyrazole derivatives with protein kinase activity
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
HUP0104302A3 (en) * 1998-11-06 2002-11-28 Abbott Gmbh & Co Kg Inhibition of the formation of vascular hyperpermeability
US6297238B1 (en) 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
ES2309088T3 (es) * 2000-09-06 2008-12-16 Ortho-Mcneil Pharmaceutical, Inc. Uso de pirazoles sustituidos para el tratamiento de alergias.
AU2001296542B2 (en) * 2000-10-02 2007-10-25 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
EP1603885A1 (en) * 2003-03-07 2005-12-14 Abbott Laboratories Fused tri and tetra-cyclic pyrazole kinase inhibitors
US7320986B2 (en) * 2003-03-07 2008-01-22 Abbott Labortories Fused tri and tetra-cyclic pyrazole kinase inhibitors
HUE027546T2 (en) 2003-08-29 2016-10-28 Brigham & Womens Hospital Inc Hydantoin derivatives as cell necrosis inhibitors
JP2008515992A (ja) 2004-10-13 2008-05-15 ピーティーシー セラピューティクス，インコーポレーテッド 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用
RS20090208A (sr) * 2006-10-31 2010-06-30 Pfizer Products Inc. Pirazolin jedinjenja kao antagonisti mineralokortikoid receptora
WO2009089285A2 (en) * 2008-01-07 2009-07-16 Emory University Branched diepoxide compounds for the treatment of inflammatory disorders
US20120122889A1 (en) 2008-12-23 2012-05-17 President And Fellows Of Harvard College Small molecule inhibitors of necroptosis
EP2968276A4 (en) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybrid necroptosis inhibitors
EP3022185B1 (en) * 2013-07-15 2017-09-06 Basf Se Pesticide compounds
CN107530350A (zh) 2014-12-11 2018-01-02 哈佛理事会 细胞坏死抑制剂及相关方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816438A (en) * 1972-12-22 1974-06-11 Sandoz Ag 2h(1)-benzothiepino(5,4-c)-pyrazoles and(1)-benzothiopyrano(4,3-c)-pyrazoles
US3843664A (en) * 1973-02-20 1974-10-22 Sandoz Ag Substituted naphtho pyrazoles

Also Published As

Publication number Publication date
DE2317716A1 (de) 1974-05-02
AU4765672A (en) 1974-04-26
DE2249644A1 (de) 1973-04-19
NL7304722A (OSRAM) 1974-05-02
FR2157852A1 (OSRAM) 1973-06-08
US3932430A (en) 1976-01-13
BE806671R (fr) 1974-04-29
NL7213549A (OSRAM) 1973-04-17
BE789948A (fr) 1973-04-11

Similar Documents

Publication Publication Date Title
BE797964R (fr) Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE799332A (fr) Nouveaux derives du benzothiadiazole, leur preparation et leur application comme medicaments
BE783219A (fr) Nouveaux composes heterocycliques, leur preparation et leur applicationcomme medicaments
BE791699A (fr) Nouveaux derives du thioxanthene, leur preparation et leur application comme medicaments
BE785937A (fr) Nouveaux derives de la quinazoline, leur preparation et leur application comme medicaments
BE792078A (fr) Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
BE783625A (fr) Nouveaux derives de l'ergolene, leur preparation et leur application comme medicaments
BE787235A (fr) Nouveaux derives du thiophene, leur preparation et leur application comme medicaments
BE790604A (fr) Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
BE792515A (fr) Nouveaux derives de l'acide lysergique, leur preparation et leur application comme medicaments
BE787804A (fr) Nouveaux composes spiranniques, leur preparation et leur application comme medicaments
BE825643A (fr) Nouveaux derives du biphenyle, leur preparation et leur application comme medicaments
BE788476A (fr) Nouveaux derives de la pyridazinone, leur preparation et leur application comme medicaments
BE787059A (fr) Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
BE776315A (fr) Nouveaux derives de la 1-amino-isoquinoleine, leur preparation et leur application comme medicaments
BE779586A (fr) Nouveaux derives de la p-phenylene-diamine, leur preparation etleur application comme medicaments
BE781013A (fr) Nouveaux derives de la quinoleine, leur preparation et leur applicationcomme medicaments
BE779402A (fr) Nouveaux derives du 2-amino-propanol, leur preparation et leur application comme medicaments
FR2314715A1 (fr) Nouveaux derives du benzo-cyclohepta-thiophene, leur preparation et leur application comme medicaments
FR2323386A1 (fr) Nouveaux derives de la benzo-cyclohepta-pyridine, leur preparation et leur application comme medicaments
BE844881A (fr) Nouveaux derives de la morphanthridine, leur preparation et leur application comme medicaments
BE785389A (fr) Nouveaux amino-alcools, leur preparation et leur application comme medicaments
BE820943A (fr) Nouveaux derives du benzo-cyclophepta-thiophene leur preparation et leur application comme medicaments
BE791098A (fr) Nouveaux derives de la pyridazine, leur preparation et leur applicationcomme medicaments
BE806526A (fr) Nouveaux derives de l'imidazo-quinazoline, leur preparation et leur application comme medicaments