BE796859A - Biotin prodn - by microbiological oxidn of cis-tetrahydro -2-oxo-4-n-pentyl-thieno (3,4-d) imidazoline - Google Patents

Biotin prodn - by microbiological oxidn of cis-tetrahydro -2-oxo-4-n-pentyl-thieno (3,4-d) imidazoline

Info

Publication number
BE796859A
BE796859A BE128860A BE128860A BE796859A BE 796859 A BE796859 A BE 796859A BE 128860 A BE128860 A BE 128860A BE 128860 A BE128860 A BE 128860A BE 796859 A BE796859 A BE 796859A
Authority
BE
Belgium
Prior art keywords
biotin
oxidn
ferm
prodn
thieno
Prior art date
Application number
BE128860A
Other languages
French (fr)
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of BE796859A publication Critical patent/BE796859A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin

Abstract

Biotin is prepd by enzymatic oxidn of the title cpd of formula (I): in the presence of a micro organism. Pref. strains of microorganism are Pseudomonas mutabilis B-3253 Ferm-P No. 1429, Corynebacterium primorioxydans B-321 Ferm-P No. 1427 and C.primorioxydans var forte B-323 Ferm-P No. 1428. Fermentation takes place in a culture medium contg sources of C and N and trace elements at pH 4-8 and 25-37 degrees C pref. with aeration and stirring for 2-7 days. biotin is a food additive and is also used in the fermentation ind.
BE128860A 1972-06-13 1973-03-16 Biotin prodn - by microbiological oxidn of cis-tetrahydro -2-oxo-4-n-pentyl-thieno (3,4-d) imidazoline BE796859A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5926772A JPS50919B2 (en) 1972-06-13 1972-06-13

Publications (1)

Publication Number Publication Date
BE796859A true BE796859A (en) 1973-09-17

Family

ID=13108414

Family Applications (1)

Application Number Title Priority Date Filing Date
BE128860A BE796859A (en) 1972-06-13 1973-03-16 Biotin prodn - by microbiological oxidn of cis-tetrahydro -2-oxo-4-n-pentyl-thieno (3,4-d) imidazoline

Country Status (2)

Country Link
JP (1) JPS50919B2 (en)
BE (1) BE796859A (en)

Also Published As

Publication number Publication date
JPS4919087A (en) 1974-02-20
JPS50919B2 (en) 1975-01-13

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