BE788479A - Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques - Google Patents
Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiquesInfo
- Publication number
- BE788479A BE788479A BE788479DA BE788479A BE 788479 A BE788479 A BE 788479A BE 788479D A BE788479D A BE 788479DA BE 788479 A BE788479 A BE 788479A
- Authority
- BE
- Belgium
- Prior art keywords
- tetracyclines
- aminomethane
- hydroxymethyl
- complexes
- tris
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 231100000252 nontoxic Toxicity 0.000 title 1
- 230000003000 nontoxic effect Effects 0.000 title 1
- 239000000243 solution Substances 0.000 title 1
- 150000003522 tetracyclines Chemical class 0.000 title 1
- 229940040944 tetracyclines Drugs 0.000 title 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4153371A GB1401178A (en) | 1971-09-06 | 1971-09-06 | Complexes of tetracyclines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE788479A true BE788479A (fr) | 1973-01-02 |
Family
ID=10420133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE788479D BE788479A (fr) | 1971-09-06 | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4418060A (cs) |
| JP (1) | JPS587610B2 (cs) |
| BE (1) | BE788479A (cs) |
| CS (1) | CS226153B2 (cs) |
| DE (1) | DE2243776C2 (cs) |
| FR (1) | FR2154464B1 (cs) |
| GB (1) | GB1401178A (cs) |
| HK (1) | HK58877A (cs) |
| PL (1) | PL83459B1 (cs) |
| YU (1) | YU225972A (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788479A (fr) | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
| EP1075265B1 (en) * | 1998-05-08 | 2006-03-08 | The University Of Miami | Use of tetracyclines for treating meibomian gland disease |
| EP1153010A1 (en) | 1999-02-08 | 2001-11-14 | Checkpoint Genetics, Inc. | $i(N)-SUBSTITUTED AMINO ACIDS, ANTIOXIDANT PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS USING SAME |
| US7485319B2 (en) * | 2003-07-25 | 2009-02-03 | Warner Chilcott Company, Inc. | Doxycycline metal complex in a solid dosage form |
| KR101171408B1 (ko) | 2004-05-21 | 2012-08-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 테트라사이클린 및 이의 유사체의 합성 |
| JP5235416B2 (ja) * | 2005-01-21 | 2013-07-10 | ワーナー・チルコット・カンパニー・エルエルシー | 固体投与形中のテトラサイクリン金属錯体 |
| EP2016044B1 (en) * | 2006-04-07 | 2020-06-10 | President and Fellows of Harvard College | Pentacycline derivatives for the treatment of infections |
| EP2076133B1 (en) | 2006-10-11 | 2012-12-12 | President and Fellows of Harvard College | Synthesis of enone intermediate |
| US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE754346A (fr) * | 1969-08-06 | 1971-01-18 | Bru Jean | Composition pharmaceutique a base de tetracycline presentee sous une forme effervescente |
| BE788479A (fr) | 1971-09-06 | 1973-01-02 | Medimpex Gyogyszerkulkereskede | Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques |
-
0
- BE BE788479D patent/BE788479A/xx not_active IP Right Cessation
-
1971
- 1971-09-06 GB GB4153371A patent/GB1401178A/en not_active Expired
-
1972
- 1972-09-05 CS CS726077A patent/CS226153B2/cs unknown
- 1972-09-05 FR FR7231461A patent/FR2154464B1/fr not_active Expired
- 1972-09-06 JP JP47089455A patent/JPS587610B2/ja not_active Expired
- 1972-09-06 YU YU02259/72A patent/YU225972A/xx unknown
- 1972-09-06 DE DE2243776A patent/DE2243776C2/de not_active Expired
- 1972-09-06 PL PL1972157620A patent/PL83459B1/pl unknown
-
1977
- 1977-11-24 HK HK588/77A patent/HK58877A/xx unknown
-
1979
- 1979-09-17 US US06/076,337 patent/US4418060A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2154464B1 (cs) | 1975-10-31 |
| DE2243776A1 (de) | 1973-03-22 |
| CS226153B2 (en) | 1984-03-19 |
| FR2154464A1 (cs) | 1973-05-11 |
| YU225972A (en) | 1982-02-28 |
| JPS587610B2 (ja) | 1983-02-10 |
| JPS4861610A (cs) | 1973-08-29 |
| PL83459B1 (cs) | 1975-12-31 |
| GB1401178A (en) | 1975-07-16 |
| DE2243776C2 (de) | 1983-01-27 |
| US4418060A (en) | 1983-11-29 |
| HK58877A (en) | 1977-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: MEDIMPEX GYOGYSZERKULKERESKEDELMI VALLALAT Effective date: 19870930 |