BE775775A - Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph - Google Patents

Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Info

Publication number
BE775775A
BE775775A BE775775A BE775775A BE775775A BE 775775 A BE775775 A BE 775775A BE 775775 A BE775775 A BE 775775A BE 775775 A BE775775 A BE 775775A BE 775775 A BE775775 A BE 775775A
Authority
BE
Belgium
Prior art keywords
ester
amino
oligopeptides
chloroethyl
antitumour
Prior art date
Application number
BE775775A
Other languages
French (fr)
Original Assignee
Belfanti Ist Sieroterap Milan
Belfanti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Belfanti Ist Sieroterap Milan, Belfanti filed Critical Belfanti Ist Sieroterap Milan
Priority to BE775775A priority Critical patent/BE775775A/en
Publication of BE775775A publication Critical patent/BE775775A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Oligopeptides of formula: (where R1 is H, prolyl, (N-formyl)p-fluorophenylalanyl, p-fluorophenylalanylaspartyl (Et ester), p-fluorophenylalanylglycyl or seryl-p-fluorophenylalanyl; R2 is OH, NHNH2 or OX, where X is Me, Et or an N-linked residue derived from p-fluorophenylalanine Et ester, asparagine Et ester, lysine Et ester, leucine Et ester, lysyl-leucine Et ester, lysyl-p-fluorophenylalanine Et ester, NO2-arginyl-leucine Et ester, NO2-arginyl-p-fluorophenylalanine Et ester, or arginyl-ornithyl-m- di(2-chloroethyl)amino phenylalanyl-histidine Me ester, all amino acids being in the L-confign.) are antitumour agents which may be prepd. by standards methods.
BE775775A 1971-11-24 1971-11-24 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph BE775775A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BE775775A BE775775A (en) 1971-11-24 1971-11-24 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE775775A BE775775A (en) 1971-11-24 1971-11-24 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Publications (1)

Publication Number Publication Date
BE775775A true BE775775A (en) 1972-03-16

Family

ID=3858916

Family Applications (1)

Application Number Title Priority Date Filing Date
BE775775A BE775775A (en) 1971-11-24 1971-11-24 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Country Status (1)

Country Link
BE (1) BE775775A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031119A1 (en) * 1998-11-19 2000-06-02 Ptc Pharma Ag Method for producing l-prolyl-l-m-sarcolysyl-l-p-fluorophenylalanine and derivatives thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000031119A1 (en) * 1998-11-19 2000-06-02 Ptc Pharma Ag Method for producing l-prolyl-l-m-sarcolysyl-l-p-fluorophenylalanine and derivatives thereof
US6767992B1 (en) 1998-11-19 2004-07-27 Ptc Pharma Ag Method for producing L-prolyl-L-M-sarcolysyl-L-p-fluorophenylalanine and derivatives thereof

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ISTITUTO SIEROTERAPICO MILANESE S. BELFANTI

Effective date: 19911124