FR2094175A1 - Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph - Google Patents

Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Info

Publication number
FR2094175A1
FR2094175A1 FR7029723A FR7029723A FR2094175A1 FR 2094175 A1 FR2094175 A1 FR 2094175A1 FR 7029723 A FR7029723 A FR 7029723A FR 7029723 A FR7029723 A FR 7029723A FR 2094175 A1 FR2094175 A1 FR 2094175A1
Authority
FR
France
Prior art keywords
ester
amino
oligopeptides
chloroethyl
antitumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7029723A
Other languages
French (fr)
Other versions
FR2094175B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISTITUTO SIEROTERAPIC
Original Assignee
ISTITUTO SIEROTERAPIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISTITUTO SIEROTERAPIC filed Critical ISTITUTO SIEROTERAPIC
Publication of FR2094175A1 publication Critical patent/FR2094175A1/en
Application granted granted Critical
Publication of FR2094175B1 publication Critical patent/FR2094175B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oligopeptides of formula: (where R1 is H, prolyl, (N-formyl)p-fluorophenylalanyl, p-fluorophenylalanylaspartyl (Et ester), p-fluorophenylalanylglycyl or seryl-p-fluorophenylalanyl; R2 is OH, NHNH2 or OX, where X is Me, Et or an N-linked residue derived from p-fluorophenylalanine Et ester, asparagine Et ester, lysine Et ester, leucine Et ester, lysyl-leucine Et ester, lysyl-p-fluorophenylalanine Et ester, NO2-arginyl-leucine Et ester, NO2-arginyl-p-fluorophenylalanine Et ester, or arginyl-ornithyl-m- di(2-chloroethyl)amino phenylalanyl-histidine Me ester, all amino acids being in the L-confign.) are antitumour agents which may be prepd. by standards methods.
FR7029723A 1970-06-11 1970-08-12 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph Granted FR2094175A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4558570A 1970-06-11 1970-06-11

Publications (2)

Publication Number Publication Date
FR2094175A1 true FR2094175A1 (en) 1972-02-04
FR2094175B1 FR2094175B1 (en) 1974-08-30

Family

ID=21938771

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7029723A Granted FR2094175A1 (en) 1970-06-11 1970-08-12 Antitumour oligopeptides - contg meta-(di-(2-chloroethyl)-amino)-l-ph

Country Status (1)

Country Link
FR (1) FR2094175A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002177A1 (en) * 1997-07-07 1999-01-21 Peptichemio Ag Pharmaceutical composition containing peptichemio
WO2004000365A1 (en) * 2002-06-24 2003-12-31 Ghanem Elias Ghanem Drug transport and delivery system
US6767992B1 (en) 1998-11-19 2004-07-27 Ptc Pharma Ag Method for producing L-prolyl-L-M-sarcolysyl-L-p-fluorophenylalanine and derivatives thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1160765A (en) * 1997-08-12 1999-03-05 Mitsubishi Kagaku Polyester Film Kk Fine foam-containing polyester film and image receiving paper for video printer comprising the film

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1160765A (en) * 1997-08-12 1999-03-05 Mitsubishi Kagaku Polyester Film Kk Fine foam-containing polyester film and image receiving paper for video printer comprising the film

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002177A1 (en) * 1997-07-07 1999-01-21 Peptichemio Ag Pharmaceutical composition containing peptichemio
US6767992B1 (en) 1998-11-19 2004-07-27 Ptc Pharma Ag Method for producing L-prolyl-L-M-sarcolysyl-L-p-fluorophenylalanine and derivatives thereof
WO2004000365A1 (en) * 2002-06-24 2003-12-31 Ghanem Elias Ghanem Drug transport and delivery system
EP1374907A3 (en) * 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system
AU2003245777B2 (en) * 2002-06-24 2008-05-22 Innopept, Inc. Drug transport and delivery system

Also Published As

Publication number Publication date
FR2094175B1 (en) 1974-08-30
DE2128549B2 (en) 1976-01-29
DE2128549A1 (en) 1972-01-13

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