BE774645A - 3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents - Google Patents

3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents

Info

Publication number
BE774645A
BE774645A BE774645A BE774645A BE774645A BE 774645 A BE774645 A BE 774645A BE 774645 A BE774645 A BE 774645A BE 774645 A BE774645 A BE 774645A BE 774645 A BE774645 A BE 774645A
Authority
BE
Belgium
Prior art keywords
alkyl
indole
amidopyridyl
hypotensive
indoles
Prior art date
Application number
BE774645A
Other languages
French (fr)
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Priority to BE774645A priority Critical patent/BE774645A/en
Publication of BE774645A publication Critical patent/BE774645A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. (I) and their salts (where B is R1 is H or 1-6C alkyl, 7-10C aralkyl or aroyl, R2 is H, 1-6C alkyl or aryl, R3 is H, halogen, 1-6C alkoxy, OH or 1-6C alkyl, R4 is H or halogen, or 1-6C alkyl, R5 is 5-7C cycloalkyl, X circled negative is an anion, and A is alkylene, mono- or di-ketoalkylene of up to 4C) are prepd. either by reacting a 3-haloalkyl indole with an acylated aminoheterocyclic cpd. or by acylating the free amino group on the heterocyclic ring in a cpd. derived from (I) or by reducing a cpd. (I) where the heterocyclic ring is unsatd. or by a Fisher indole synthesis. Thus 3- 2-(4-cyclohexanecarbonamido-1-piperidyl)ethyl indole is prepd. from 3-(2-bromethyl)indole and 4-cyclohexanecarboxamidopiperidine.
BE774645A 1971-10-28 1971-10-28 3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents BE774645A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BE774645A BE774645A (en) 1971-10-28 1971-10-28 3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE774645A BE774645A (en) 1971-10-28 1971-10-28 3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents

Publications (1)

Publication Number Publication Date
BE774645A true BE774645A (en) 1972-02-14

Family

ID=3858812

Family Applications (1)

Application Number Title Priority Date Filing Date
BE774645A BE774645A (en) 1971-10-28 1971-10-28 3-(cycloalkane amidopyridyl(or hydro-pyridyl)-alkyl-) - indoles - as anti inflammatory,hypotensive and antihistaminic agents

Country Status (1)

Country Link
BE (1) BE774645A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2343738A1 (en) * 1976-03-12 1977-10-07 Wyeth John & Brother Ltd INDOLES PREPARATION PROCESS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2343738A1 (en) * 1976-03-12 1977-10-07 Wyeth John & Brother Ltd INDOLES PREPARATION PROCESS

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: JOHN WYETH & BROTHER LTD

Effective date: 19871031