BE724363A - - Google Patents
Info
- Publication number
- BE724363A BE724363A BE724363DA BE724363A BE 724363 A BE724363 A BE 724363A BE 724363D A BE724363D A BE 724363DA BE 724363 A BE724363 A BE 724363A
- Authority
- BE
- Belgium
- Prior art keywords
- pancreas
- concentrate
- solvent
- insulin
- fresh
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 78
- 102000004877 Insulin Human genes 0.000 claims description 39
- 108090001061 Insulin Proteins 0.000 claims description 39
- 229940125396 insulin Drugs 0.000 claims description 39
- 210000000496 pancreas Anatomy 0.000 claims description 32
- 239000012141 concentrate Substances 0.000 claims description 29
- 210000004923 pancreatic tissue Anatomy 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 9
- 108090000790 Enzymes Proteins 0.000 claims description 9
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 239000004519 grease Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 235000015277 pork Nutrition 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 235000015278 beef Nutrition 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 230000004048 modification Effects 0.000 claims description 2
- 238000012986 modification Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims 3
- 230000004075 alteration Effects 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000013505 freshwater Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003925 fat Substances 0.000 description 11
- 229940088598 enzyme Drugs 0.000 description 8
- 239000000047 product Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 238000005238 degreasing Methods 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000010533 azeotropic distillation Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- KNKRKFALVUDBJE-UHFFFAOYSA-N 1,2-dichloropropane Chemical compound CC(Cl)CCl KNKRKFALVUDBJE-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- CYTYCFOTNPOANT-UHFFFAOYSA-N Perchloroethylene Chemical group ClC(Cl)=C(Cl)Cl CYTYCFOTNPOANT-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE724363 | 1968-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE724363A true BE724363A (enrdf_load_stackoverflow) | 1969-05-02 |
Family
ID=3853872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE724363D BE724363A (enrdf_load_stackoverflow) | 1968-11-22 | 1968-11-22 |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE724363A (enrdf_load_stackoverflow) |
-
1968
- 1968-11-22 BE BE724363D patent/BE724363A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5908034A (en) | Method for making a band cast reconstituted tobacco sheet using steam exploded tobacco | |
| CA2313130A1 (en) | A method for making a reconstituted tobacco sheet using steam exploded tobacco | |
| CH635491A5 (fr) | Procede de desamerisation d'un hydrolysat de proteines et hydrolysat desamerise obtenu. | |
| US2131394A (en) | Production of vegetable concentrates | |
| EP0456023B1 (fr) | Procédé d'obtention de complexes de catechines | |
| CH616315A5 (enrdf_load_stackoverflow) | ||
| BE724363A (enrdf_load_stackoverflow) | ||
| CN1430971A (zh) | 鹿茸有效成分低温超声裂解浸提法 | |
| CH635732A5 (fr) | Procede de desamerisation d'un extrait de fruits ou de legumes et extrait desamerise obtenu. | |
| US3468674A (en) | Method of processing fresh meat and fish | |
| US4077950A (en) | Process for the recovery of substantially water-soluble non-toxic protein compounds from fresh non-woody vegetation | |
| CN113749252B (zh) | 一种提高陈皮(柑橘皮)粉品质的加工方法 | |
| EP0085589B1 (fr) | Procédé de préparation de suspensions de cellules fraîches stabilisées destinées à l'usage pharmaceutique, cosmétique et alimentaire | |
| GB2094334A (en) | Extracting oil, protein and flour from fresh coconut meat | |
| EP3437648A1 (en) | Method for producing nepodin-rich extract of rumex plant and nepodin-rich extract of rumex plant | |
| KR100691805B1 (ko) | 어호엔을 알코올 분해 효소 저해제로 사용하는 방법, 상기 어호엔을 포함하는 숙취 제거 조성물 및 상기 숙취 제거 조성물의 제조 방법 | |
| FR2618303A1 (fr) | Preparation de gelatine presentant un degre bloom eleve a partir de sous-produits de volaille | |
| US3676552A (en) | Stable insulin material | |
| FR2475067A1 (fr) | Procede pour la preparation d'un cristal de carbonate de sodium anhydre | |
| EP0168281A1 (fr) | Procédé de préparation d'un tripolyphosphate de sodium hexahydraté à haut pouvoir absorbant et tripolyphosphate ainsi préparé | |
| CH495114A (fr) | Procédé de préparation de granulés de matières de nature protéique | |
| JPS6235746B2 (enrdf_load_stackoverflow) | ||
| CA1202583A (fr) | Procedes de preparation de suspensions de cellules fraiches stabilisees destinees a l'usage pharmaceutique, cosmetique ou alimentaire | |
| BE1010461A3 (fr) | Procede de raffinage d'enzymes de type sulfhydrile, ainsi que les produits obtenus par ledit procede. | |
| JPS62129103A (ja) | 天然原料から有用物質の分離方法 |