BE571494A - - Google Patents
Info
- Publication number
- BE571494A BE571494A BE571494DA BE571494A BE 571494 A BE571494 A BE 571494A BE 571494D A BE571494D A BE 571494DA BE 571494 A BE571494 A BE 571494A
- Authority
- BE
- Belgium
- Prior art keywords
- substance
- solid
- suspension
- liquid
- mammals
- Prior art date
Links
- 239000000725 suspension Substances 0.000 claims description 47
- 239000000126 substance Substances 0.000 claims description 26
- 239000007787 solid Substances 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 17
- 239000002609 medium Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 12
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 9
- 229910052740 iodine Inorganic materials 0.000 claims description 9
- 241000124008 Mammalia Species 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 6
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 6
- 229960003604 testosterone Drugs 0.000 claims description 6
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 5
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
- 239000002612 dispersion medium Substances 0.000 claims description 5
- 229960003399 estrone Drugs 0.000 claims description 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052794 bromium Inorganic materials 0.000 claims description 4
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims description 3
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims description 3
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims description 3
- 229960004544 cortisone Drugs 0.000 claims description 3
- 229960000890 hydrocortisone Drugs 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 239000000186 progesterone Substances 0.000 claims description 3
- 229960003387 progesterone Drugs 0.000 claims description 3
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 2
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 claims description 2
- 229960005309 estradiol Drugs 0.000 claims description 2
- 229930182833 estradiol Natural products 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims 8
- 230000003000 nontoxic effect Effects 0.000 claims 8
- 230000003054 hormonal effect Effects 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 2
- GNOGSFBXBWBTIG-UHFFFAOYSA-M 3-acetamido-2,4,6-triiodobenzoate Chemical group CC(=O)NC1=C(I)C=C(I)C(C([O-])=O)=C1I GNOGSFBXBWBTIG-UHFFFAOYSA-M 0.000 claims 1
- WKRLQDKEXYKHJB-UHFFFAOYSA-N Equilin Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3=CCC2=C1 WKRLQDKEXYKHJB-UHFFFAOYSA-N 0.000 claims 1
- WKRLQDKEXYKHJB-HFTRVMKXSA-N equilin Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 WKRLQDKEXYKHJB-HFTRVMKXSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 16
- 239000000047 product Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 229940088597 hormone Drugs 0.000 description 8
- 239000005556 hormone Substances 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 239000012265 solid product Substances 0.000 description 5
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 4
- 239000011872 intimate mixture Substances 0.000 description 4
- 238000002601 radiography Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002872 contrast media Substances 0.000 description 3
- 239000000032 diagnostic agent Substances 0.000 description 3
- 229940039227 diagnostic agent Drugs 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical class OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 125000004494 ethyl ester group Chemical group 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- ZEYOIOAKZLALAP-UHFFFAOYSA-M sodium amidotrizoate Chemical compound [Na+].CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I ZEYOIOAKZLALAP-UHFFFAOYSA-M 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- KZDCMKVLEYCGQX-UDPGNSCCSA-N 2-(diethylamino)ethyl 4-aminobenzoate;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;hydrate Chemical compound O.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 KZDCMKVLEYCGQX-UDPGNSCCSA-N 0.000 description 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000008753 Papaver somniferum Nutrition 0.000 description 1
- 240000001090 Papaver somniferum Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 101100014660 Rattus norvegicus Gimap8 gene Proteins 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 159000000032 aromatic acids Chemical class 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- RERHJVNYJKZHLJ-UHFFFAOYSA-N bis(2-hydroxyethyl)azanium;2-(3,5-diiodo-4-oxopyridin-1-yl)acetate Chemical compound OCCNCCO.OC(=O)CN1C=C(I)C(=O)C(I)=C1 RERHJVNYJKZHLJ-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- UNWBBBCIZYEGIZ-UHFFFAOYSA-N denin Natural products C1CC2(C)C3C(O)C(O)C4(C)C(C(O)C)CCC4(O)C3CCC2CC1OC(C(C1O)O)OC(C)C1OC1OC(CO)C(O)C(O)C1O UNWBBBCIZYEGIZ-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229960005223 diatrizoic acid Drugs 0.000 description 1
- GMQNYSMZUWAAIN-UHFFFAOYSA-L disodium;3,5-diiodo-1-methyl-4-oxopyridine-2,6-dicarboxylate Chemical compound [Na+].[Na+].CN1C(C([O-])=O)=C(I)C(=O)C(I)=C1C([O-])=O GMQNYSMZUWAAIN-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- OTDVQDYTTNXRQA-UHFFFAOYSA-N ethyl 2-iodo-2-phenylundecanoate Chemical compound CCCCCCCCCC(I)(C(=O)OCC)C1=CC=CC=C1 OTDVQDYTTNXRQA-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910001505 inorganic iodide Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 150000002496 iodine Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000009608 myelography Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000010491 poppyseed oil Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- UCPVOMHRDXMAIZ-UHFFFAOYSA-M sodium acetrizoate Chemical compound [Na+].CC(=O)NC1=C(I)C=C(I)C(C([O-])=O)=C1I UCPVOMHRDXMAIZ-UHFFFAOYSA-M 0.000 description 1
- 229950011473 sodium acetrizoate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- XBMGRDWEYMVTOS-UHFFFAOYSA-M sodium;2-iodobenzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1I XBMGRDWEYMVTOS-UHFFFAOYSA-M 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE571494A true BE571494A (pm) |
Family
ID=189662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE571494D BE571494A (pm) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE571494A (pm) |
-
0
- BE BE571494D patent/BE571494A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0593624B1 (en) | Improvements in or relating to contrast agents | |
| EP0498482B1 (en) | X-ray contrast compositions useful in medical imaging | |
| RU2131744C1 (ru) | Биосовместимое контрастное средство, стабильная биосовместимая коллоидная дисперсия, способ получения ультразвукового изображения животного, способы получения стабильного при хранении контрастного средства | |
| AU696091B2 (en) | Improvements in or relating to contrast agents | |
| IE870187L (en) | Nmr contrast agent emulsions | |
| SK93095A3 (en) | Biocompatible contrast agent and dispersion with its contents | |
| JPH10500691A (ja) | コンピューター連動断層撮影用造影剤として、安定化された均質な懸濁液 | |
| US2921884A (en) | Pharmaceutical compositions | |
| WO1993025191A2 (fr) | Microspheres en polymere bioresorbable, exemptes de tensioactif, leur preparation et leur application comme medicament | |
| CA1093966A (en) | Instillation composition | |
| US6121250A (en) | Lavage solution for intestinal tract | |
| BE571494A (pm) | ||
| NO176747B (no) | Jod-holdig emulsjon og anvendelse derav for fremstilling av et röntgenkontrastmiddel | |
| US5582813A (en) | Iodine-containing fluorocarbon contrast agents | |
| JP2018150387A (ja) | 脂肪乳剤、及びその製造方法、脂肪乳剤の安定性を向上させる方法、並びに脂肪乳剤の安定性向上剤 | |
| CA1275247C (fr) | Procede de solubilisation, au moment de l'emploi, d'un principe actiflipophile dans une solution aqueuse, en vue de son administration par voie intraveineuse | |
| Rosoff | Specialized pharmaceutical emulsions | |
| JPH0222241A (ja) | 脂溶性ビタミンｋ含有水性液 | |
| JP6082405B2 (ja) | Ｘ線診断用組成物の安定化 | |
| JPS60166626A (ja) | 血管造影剤 | |
| JPS6361957B2 (pm) | ||
| FR2798133A1 (fr) | Procede d'emulsification sans broyage de silicones et emulsion thermosensible resultante | |
| EP0120583B1 (en) | Perfluorobromoalkyl ethers for use as x-ray contrast agents | |
| Sanchez et al. | Highly concentrated 1, 2-bis (perfluoroalkyl) iodoethene emulsions for use as contrast agents for diagnosis | |
| JP6368862B1 (ja) | 脂肪乳剤、及びその製造方法、脂肪乳剤の安定性を向上させる方法、並びに脂肪乳剤の安定性向上剤 |