BE520758A - - Google Patents
Info
- Publication number
- BE520758A BE520758A BE520758DA BE520758A BE 520758 A BE520758 A BE 520758A BE 520758D A BE520758D A BE 520758DA BE 520758 A BE520758 A BE 520758A
- Authority
- BE
- Belgium
- Prior art keywords
- base
- sep
- solution
- racemic
- process according
- Prior art date
Links
- 239000002585 base Substances 0.000 claims description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 238000003786 synthesis reaction Methods 0.000 claims description 7
- 230000002194 synthesizing Effects 0.000 claims description 7
- WIIZWVCIJKGZOK-RKDXNWHRSA-N Chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims description 6
- 229960005091 Chloramphenicol Drugs 0.000 claims description 6
- OCYJXSUPZMNXEN-UHFFFAOYSA-N 2-amino-1-(4-nitrophenyl)propane-1,3-diol Chemical compound OCC(N)C(O)C1=CC=C([N+]([O-])=O)C=C1 OCYJXSUPZMNXEN-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000000543 intermediate Substances 0.000 claims description 4
- 150000007530 organic bases Chemical class 0.000 claims description 4
- 239000012458 free base Substances 0.000 claims description 2
- 150000007529 inorganic bases Chemical class 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 229920001098 polystyrene-block-poly(ethylene/propylene) Polymers 0.000 description 65
- 239000000243 solution Substances 0.000 description 20
- 238000001816 cooling Methods 0.000 description 8
- 230000005712 crystallization Effects 0.000 description 7
- 238000002425 crystallisation Methods 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000875 corresponding Effects 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000007792 addition Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 230000003287 optical Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000000185 1,3-diols Chemical class 0.000 description 1
- JXTHNDFMNIQAHM-UHFFFAOYSA-N Dichloroacetic acid Chemical class OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000003472 neutralizing Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 230000002441 reversible Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE520758A true BE520758A (es) |
Family
ID=156537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE520758D BE520758A (es) |
Country Status (1)
| Country | Link |
|---|---|
| BE (1) | BE520758A (es) |
-
0
- BE BE520758D patent/BE520758A/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE1008403A4 (fr) | Procede de cristallisation d'iopamidol. | |
| JP4377219B2 (ja) | Ｒ−及びｓ−シタロプラムの混合物を分離することによってラセミシタロプラム及びｓ−もしくはｒ−シタロプラムを製造する方法 | |
| FR2562538A1 (fr) | Procede de recristallisation d'explosifs brisants | |
| FR2832146A1 (fr) | Base libre de tamsulosine racemique et ses procedes de preparation | |
| BE520758A (es) | ||
| CH318194A (fr) | Procédé de dédoublement direct du thréo-1-p-nitrophényl-2-amino-propanediol-(1,3) racémique en ses antipodes | |
| BE543617A (es) | ||
| BE505352A (es) | ||
| FR2756557A1 (fr) | Procede de dedoublement de composes 1-amino-alcan-2-ol | |
| FR3054218A1 (fr) | Procede de dedoublement de sels de baclofene | |
| JPS6323824A (ja) | 酸性α−水素を有するアミンの光学分割およびラセミ化方法 | |
| BE499947A (es) | ||
| BE500675A (es) | ||
| JPH035382B2 (es) | ||
| BE501303A (es) | ||
| BE513130A (es) | ||
| CH323913A (fr) | Procédé de préparation de l(-)thréonine par dédoublement direct de la dl-thréonine | |
| CH401082A (fr) | Procédé pour le dédoublement optique de l'acide homocystéique ou d'un sel de monoammonium de celui-ci | |
| BE513651A (es) | ||
| BE493864A (es) | ||
| BE504827A (es) | ||
| BE562280A (es) | ||
| BE546648A (es) | ||
| BE344132A (es) | ||
| BE542228A (es) |