BE493858A - - Google Patents

Info

Publication number

BE493858A

BE493858A BE493858DA BE493858A BE 493858 A BE493858 A BE 493858A BE 493858D A BE493858D A BE 493858DA BE 493858 A BE493858 A BE 493858A

Authority

BE

Belgium

Prior art keywords

crystals

glutamic acid

monoclinic

acid

solution

Prior art date

Links

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• 239000013078 crystal Substances 0.000 claims description 125
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 84
• 239000004220 glutamic acid Substances 0.000 claims description 84
• 235000013922 glutamic acid Nutrition 0.000 claims description 84
• PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 63
• 239000000243 solution Substances 0.000 claims description 55
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 48
• 239000002253 acid Substances 0.000 claims description 39
• 239000000725 suspension Substances 0.000 claims description 25
• 238000000034 method Methods 0.000 claims description 20
• 238000003756 stirring Methods 0.000 claims description 19
• 239000007864 aqueous solution Substances 0.000 claims description 17
• 229910052500 inorganic mineral Inorganic materials 0.000 claims description 15
• 239000011707 mineral Substances 0.000 claims description 15
• 239000000203 mixture Substances 0.000 claims description 15
• 238000002425 crystallisation Methods 0.000 claims description 13
• 230000008025 crystallization Effects 0.000 claims description 13
• 230000001590 oxidative effect Effects 0.000 claims description 13
• 238000004519 manufacturing process Methods 0.000 claims description 10
• 238000010924 continuous production Methods 0.000 claims description 7
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 75
• 229960002989 glutamic acid Drugs 0.000 description 73
• 238000002360 preparation method Methods 0.000 description 15
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
• 238000007792 addition Methods 0.000 description 11
• 238000010899 nucleation Methods 0.000 description 7
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
• 239000012452 mother liquor Substances 0.000 description 5
• 239000000047 product Substances 0.000 description 5
• 239000011734 sodium Substances 0.000 description 5
• 229910052708 sodium Inorganic materials 0.000 description 5
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
• 238000013019 agitation Methods 0.000 description 4
• 238000002156 mixing Methods 0.000 description 4
• 238000010979 pH adjustment Methods 0.000 description 4
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 230000015572 biosynthetic process Effects 0.000 description 3
• QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 description 2
• 238000001816 cooling Methods 0.000 description 2
• 230000001747 exhibiting effect Effects 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 239000012535 impurity Substances 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 238000000746 purification Methods 0.000 description 2
• 229920006395 saturated elastomer Polymers 0.000 description 2
• 239000012047 saturated solution Substances 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• 235000021536 Sugar beet Nutrition 0.000 description 1
• 241000209140 Triticum Species 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 238000005054 agglomeration Methods 0.000 description 1
• 230000002776 aggregation Effects 0.000 description 1
• 238000010923 batch production Methods 0.000 description 1
• 238000005219 brazing Methods 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 210000004027 cell Anatomy 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 235000013339 cereals Nutrition 0.000 description 1
• 210000002858 crystal cell Anatomy 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 239000000428 dust Substances 0.000 description 1
• 238000010410 dusting Methods 0.000 description 1
• 238000004880 explosion Methods 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000012634 fragment Substances 0.000 description 1
• 235000021312 gluten Nutrition 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 231100001261 hazardous Toxicity 0.000 description 1
• 230000001788 irregular Effects 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 239000011343 solid material Substances 0.000 description 1
• 239000007858 starting material Substances 0.000 description 1
• 238000003860 storage Methods 0.000 description 1