BE1005342A5 - Materiau de restauration d'un defaut osseux par comblement par du tissu osseux. - Google Patents
Materiau de restauration d'un defaut osseux par comblement par du tissu osseux. Download PDFInfo
- Publication number
- BE1005342A5 BE1005342A5 BE9000433A BE9000433A BE1005342A5 BE 1005342 A5 BE1005342 A5 BE 1005342A5 BE 9000433 A BE9000433 A BE 9000433A BE 9000433 A BE9000433 A BE 9000433A BE 1005342 A5 BE1005342 A5 BE 1005342A5
- Authority
- BE
- Belgium
- Prior art keywords
- particles
- bone
- bone tissue
- cavity
- tissue
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 75
- 239000000463 material Substances 0.000 title claims abstract description 24
- 238000011049 filling Methods 0.000 title claims abstract description 14
- 239000002245 particle Substances 0.000 claims abstract description 94
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000001788 irregular Effects 0.000 claims abstract description 4
- 239000011521 glass Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 230000011164 ossification Effects 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 4
- 230000002546 agglutinic effect Effects 0.000 claims description 2
- 238000005266 casting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 102200021395 rs3739168 Human genes 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 abstract description 29
- 230000007547 defect Effects 0.000 abstract description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 18
- 229910052681 coesite Inorganic materials 0.000 abstract description 6
- 229910052906 cristobalite Inorganic materials 0.000 abstract description 6
- 239000000377 silicon dioxide Substances 0.000 abstract description 6
- 229910052682 stishovite Inorganic materials 0.000 abstract description 6
- 229910052905 tridymite Inorganic materials 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 235000012239 silicon dioxide Nutrition 0.000 abstract description 2
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 16
- 238000009412 basement excavation Methods 0.000 description 14
- 239000001506 calcium phosphate Substances 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 13
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 13
- 229910000389 calcium phosphate Inorganic materials 0.000 description 12
- 235000011010 calcium phosphates Nutrition 0.000 description 12
- 210000000963 osteoblast Anatomy 0.000 description 12
- 230000004820 osteoconduction Effects 0.000 description 12
- 230000004069 differentiation Effects 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 9
- 238000002513 implantation Methods 0.000 description 9
- 239000010410 layer Substances 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 239000002131 composite material Substances 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 229910000287 alkaline earth metal oxide Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 2
- 229910001634 calcium fluoride Inorganic materials 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 208000035824 paresthesia Diseases 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010061728 Bone lesion Diseases 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010013886 Dysaesthesia Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Ceramic Engineering (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR898905504A FR2646084B1 (fr) | 1989-04-20 | 1989-04-20 | Materiau bioreactif de remplissage de cavites osseuses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1005342A5 true BE1005342A5 (fr) | 1993-07-06 |
Family
ID=9381126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE9000433A BE1005342A5 (fr) | 1989-04-20 | 1990-04-19 | Materiau de restauration d'un defaut osseux par comblement par du tissu osseux. |
Country Status (11)
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5344456A (en) * | 1989-06-06 | 1994-09-06 | Tdk Corporation | Materials for living hard tissue replacements |
| US5269785A (en) * | 1990-06-28 | 1993-12-14 | Bonutti Peter M | Apparatus and method for tissue removal |
| US6990982B1 (en) | 1990-06-28 | 2006-01-31 | Bonutti Ip, Llc | Method for harvesting and processing cells from tissue fragments |
| US5329846A (en) | 1991-08-12 | 1994-07-19 | Bonutti Peter M | Tissue press and system |
| US6503277B2 (en) * | 1991-08-12 | 2003-01-07 | Peter M. Bonutti | Method of transplanting human body tissue |
| US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
| FR2681787B1 (fr) * | 1991-09-26 | 1993-11-26 | Pachoud Christine | Procede pour la realisation d'une poudre destinee a la fabrication d'os de synthese, poudre et produits ainsi realises. |
| WO1994004657A1 (en) * | 1992-08-13 | 1994-03-03 | The Trustees Of The University Of Pennsylvania | Bioactive material template for in vitro synthesis of bone tissue |
| US5658332A (en) * | 1994-06-30 | 1997-08-19 | Orthovita, Inc. | Bioactive granules for bone tissue formation |
| US5817327A (en) * | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| US5628630A (en) * | 1994-12-15 | 1997-05-13 | Univ. Of Alabama At Birmingham | Design process for skeletal implants to optimize cellular response |
| US5681872A (en) * | 1995-12-07 | 1997-10-28 | Orthovita, Inc. | Bioactive load bearing bone graft compositions |
| PT877716E (pt) * | 1996-01-29 | 2005-02-28 | Usbiomaterials Corp | Composicoes de vidro bioactivo para uso no tratamento de estruturas dentais |
| AU723659B2 (en) * | 1996-01-29 | 2000-08-31 | Novamin Technology, Inc. | Bioactive glass compositions and methods of treatment using bioactive glass |
| US5735942A (en) | 1996-02-07 | 1998-04-07 | Usbiomaterials Corporation | Compositions containing bioactive glass and their use in treating tooth hypersensitivity |
| US5788976A (en) * | 1996-02-12 | 1998-08-04 | Wbk, Inc. | Method for effecting bone repair |
| AU2326997A (en) | 1996-03-18 | 1997-10-10 | Trustees Of The University Of Pennsylvania, The | Bioactive material substrate for enhanced cellular attachment and function |
| KR20000065167A (ko) * | 1996-05-01 | 2000-11-06 | 유니버시티 오브 플로리다 | 생활성세라믹및그의제조방법 |
| US5830480A (en) * | 1996-05-09 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Stabilization of sol-gel derived silica-based glass |
| US6224913B1 (en) | 1996-05-09 | 2001-05-01 | The Trustees Of The University Of Pennsylvania | Conditioning of bioactive glass surfaces in protein containing solutions |
| US6416774B1 (en) | 1996-05-09 | 2002-07-09 | The Trustees Of The University Of Pennsyvania | Hollow bone mineral-like calcium phosphate particles |
| US5964807A (en) * | 1996-08-08 | 1999-10-12 | Trustees Of The University Of Pennsylvania | Compositions and methods for intervertebral disc reformation |
| US5718717A (en) | 1996-08-19 | 1998-02-17 | Bonutti; Peter M. | Suture anchor |
| US5914356A (en) * | 1996-12-06 | 1999-06-22 | Orthovita, Inc. | Bioactive load bearing bone bonding compositions |
| US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| US5874101A (en) * | 1997-04-14 | 1999-02-23 | Usbiomaterials Corp. | Bioactive-gel compositions and methods |
| FI103715B (fi) * | 1997-04-21 | 1999-08-31 | Vivoxid Oy | Uusi komposiitti ja sen käyttö |
| IN191261B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1997-09-18 | 2003-10-18 | Univ Maryland | |
| AU1942099A (en) | 1997-12-19 | 1999-07-12 | Us Biomaterials Corporation | Tape cast multi-layer ceramic/metal composites |
| US6045551A (en) | 1998-02-06 | 2000-04-04 | Bonutti; Peter M. | Bone suture |
| GB9820369D0 (en) * | 1998-09-19 | 1998-11-11 | Giltech Ltd | Material |
| FI110062B (fi) * | 1998-12-11 | 2002-11-29 | Antti Yli-Urpo | Uusi komposiitti ja sen käyttö |
| US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
| US6482427B2 (en) | 1999-04-23 | 2002-11-19 | Unicare Biomedical, Inc. | Compositions and methods for repair of osseous defects and accelerated wound healing |
| US6228386B1 (en) | 1999-04-23 | 2001-05-08 | Unicare Biomedical, Inc. | Compositions and methods to repair osseous defects |
| US6368343B1 (en) | 2000-03-13 | 2002-04-09 | Peter M. Bonutti | Method of using ultrasonic vibration to secure body tissue |
| US6447516B1 (en) | 1999-08-09 | 2002-09-10 | Peter M. Bonutti | Method of securing tissue |
| US6458162B1 (en) * | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
| US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
| US7935147B2 (en) | 1999-10-20 | 2011-05-03 | Anulex Technologies, Inc. | Method and apparatus for enhanced delivery of treatment device to the intervertebral disc annulus |
| US7052516B2 (en) | 1999-10-20 | 2006-05-30 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and deformable spinal disc annulus stent |
| US7004970B2 (en) | 1999-10-20 | 2006-02-28 | Anulex Technologies, Inc. | Methods and devices for spinal disc annulus reconstruction and repair |
| US8632590B2 (en) | 1999-10-20 | 2014-01-21 | Anulex Technologies, Inc. | Apparatus and methods for the treatment of the intervertebral disc |
| US7951201B2 (en) | 1999-10-20 | 2011-05-31 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
| US7615076B2 (en) | 1999-10-20 | 2009-11-10 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
| WO2001028464A1 (en) | 1999-10-20 | 2001-04-26 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
| US8128698B2 (en) | 1999-10-20 | 2012-03-06 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
| EP1974698A3 (en) | 1999-10-20 | 2009-01-28 | Anulex Technologies, Inc. | Spinal disc annulus stent |
| US6635073B2 (en) | 2000-05-03 | 2003-10-21 | Peter M. Bonutti | Method of securing body tissue |
| RU2251405C2 (ru) * | 2000-03-27 | 2005-05-10 | Шотт Глас | Композиции для косметических препаратов, средств личной гигиены, компонентов очищающего действия, пищевых добавок, способы их получения и применения |
| US6709744B1 (en) | 2001-08-13 | 2004-03-23 | The Curators Of The University Of Missouri | Bioactive materials |
| US7750063B2 (en) | 2001-10-24 | 2010-07-06 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7204874B2 (en) | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Root canal filling material |
| US7204875B2 (en) * | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7211136B2 (en) * | 2001-10-24 | 2007-05-01 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7303817B2 (en) * | 2001-10-24 | 2007-12-04 | Weitao Jia | Dental filling material |
| US6719765B2 (en) | 2001-12-03 | 2004-04-13 | Bonutti 2003 Trust-A | Magnetic suturing system and method |
| US20030220692A1 (en) * | 2002-02-09 | 2003-11-27 | Shapiro Irving M. | Preparations of nucleus pulposus cells and methods for their generation, identification, and use |
| US7299805B2 (en) | 2002-06-07 | 2007-11-27 | Marctec, Llc | Scaffold and method for implanting cells |
| US8551100B2 (en) | 2003-01-15 | 2013-10-08 | Biomet Manufacturing, Llc | Instrumentation for knee resection |
| US7789885B2 (en) | 2003-01-15 | 2010-09-07 | Biomet Manufacturing Corp. | Instrumentation for knee resection |
| US7837690B2 (en) | 2003-01-15 | 2010-11-23 | Biomet Manufacturing Corp. | Method and apparatus for less invasive knee resection |
| US7887542B2 (en) | 2003-01-15 | 2011-02-15 | Biomet Manufacturing Corp. | Method and apparatus for less invasive knee resection |
| JP2007509716A (ja) * | 2003-10-29 | 2007-04-19 | ジェンティス インコーポレイテッド | 組織工学用の重合可能なエマルション |
| US7488324B1 (en) | 2003-12-08 | 2009-02-10 | Biomet Manufacturing Corporation | Femoral guide for implanting a femoral knee prosthesis |
| US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
| US7695479B1 (en) | 2005-04-12 | 2010-04-13 | Biomet Manufacturing Corp. | Femoral sizer |
| US8070752B2 (en) | 2006-02-27 | 2011-12-06 | Biomet Manufacturing Corp. | Patient specific alignment guide and inter-operative adjustment |
| US8591516B2 (en) | 2006-02-27 | 2013-11-26 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
| US9345548B2 (en) | 2006-02-27 | 2016-05-24 | Biomet Manufacturing, Llc | Patient-specific pre-operative planning |
| US7780672B2 (en) | 2006-02-27 | 2010-08-24 | Biomet Manufacturing Corp. | Femoral adjustment device and associated method |
| US8407067B2 (en) | 2007-04-17 | 2013-03-26 | Biomet Manufacturing Corp. | Method and apparatus for manufacturing an implant |
| US9113971B2 (en) | 2006-02-27 | 2015-08-25 | Biomet Manufacturing, Llc | Femoral acetabular impingement guide |
| US9173661B2 (en) | 2006-02-27 | 2015-11-03 | Biomet Manufacturing, Llc | Patient specific alignment guide with cutting surface and laser indicator |
| US9918740B2 (en) | 2006-02-27 | 2018-03-20 | Biomet Manufacturing, Llc | Backup surgical instrument system and method |
| US9339278B2 (en) | 2006-02-27 | 2016-05-17 | Biomet Manufacturing, Llc | Patient-specific acetabular guides and associated instruments |
| US8603180B2 (en) | 2006-02-27 | 2013-12-10 | Biomet Manufacturing, Llc | Patient-specific acetabular alignment guides |
| US9907659B2 (en) | 2007-04-17 | 2018-03-06 | Biomet Manufacturing, Llc | Method and apparatus for manufacturing an implant |
| US10278711B2 (en) | 2006-02-27 | 2019-05-07 | Biomet Manufacturing, Llc | Patient-specific femoral guide |
| US20150335438A1 (en) | 2006-02-27 | 2015-11-26 | Biomet Manufacturing, Llc. | Patient-specific augments |
| US9289253B2 (en) | 2006-02-27 | 2016-03-22 | Biomet Manufacturing, Llc | Patient-specific shoulder guide |
| GB2436067A (en) * | 2006-03-17 | 2007-09-19 | Apatech Ltd | A flowable biomedical filler resisiting flow at higher shear stress or compressive force |
| GB0607605D0 (en) * | 2006-04-18 | 2006-05-24 | Smith & Nephew | Composition |
| US7695520B2 (en) | 2006-05-31 | 2010-04-13 | Biomet Manufacturing Corp. | Prosthesis and implementation system |
| US9795399B2 (en) | 2006-06-09 | 2017-10-24 | Biomet Manufacturing, Llc | Patient-specific knee alignment guide and associated method |
| JP5450063B2 (ja) | 2006-06-29 | 2014-03-26 | オーソヴィータ・インコーポレーテッド | 生体活性骨移植片代替物 |
| WO2008035816A1 (fr) | 2006-09-21 | 2008-03-27 | Toshiki Oguro | Promoteur de régénération des tissus durs |
| US8163022B2 (en) | 2008-10-14 | 2012-04-24 | Anulex Technologies, Inc. | Method and apparatus for the treatment of the intervertebral disc annulus |
| US8481066B2 (en) * | 2009-07-16 | 2013-07-09 | The Curators Of The University Of Missouri | Scaffold for tissue regeneration in mammals |
| US8287896B2 (en) * | 2010-01-06 | 2012-10-16 | The Curators Of The University Of Missouri | Scaffolds with trace element for tissue regeneration in mammals |
| ES2816576T3 (es) | 2009-07-16 | 2021-04-05 | Univ Missouri | Andamios con oligoelementos para la regeneración de tejidos en mamíferos |
| US8337875B2 (en) * | 2009-07-16 | 2012-12-25 | The Curators Of The University Of Missouri | Controlling vessel growth and directionality in mammals and implantable material |
| US8778378B2 (en) | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
| US8460319B2 (en) | 2010-01-11 | 2013-06-11 | Anulex Technologies, Inc. | Intervertebral disc annulus repair system and method |
| US9968376B2 (en) | 2010-11-29 | 2018-05-15 | Biomet Manufacturing, Llc | Patient-specific orthopedic instruments |
| US9241745B2 (en) | 2011-03-07 | 2016-01-26 | Biomet Manufacturing, Llc | Patient-specific femoral version guide |
| US8871235B2 (en) | 2011-10-24 | 2014-10-28 | Synergy Biomedical Llc | Compositions and their use in bone healing |
| US10179012B2 (en) | 2013-01-28 | 2019-01-15 | Cartiva, Inc. | Systems and methods for orthopedic repair |
| US9737294B2 (en) | 2013-01-28 | 2017-08-22 | Cartiva, Inc. | Method and system for orthopedic repair |
| US10722310B2 (en) | 2017-03-13 | 2020-07-28 | Zimmer Biomet CMF and Thoracic, LLC | Virtual surgery planning system and method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4159358A (en) * | 1977-05-19 | 1979-06-26 | Board Of Regents, State Of Florida | Method of bonding a bioglass to metal |
| EP0145210A2 (en) * | 1983-10-27 | 1985-06-19 | E.I. Du Pont De Nemours And Company | Support particles coated with precursors biologically active glass |
| EP0206726A2 (en) * | 1985-06-19 | 1986-12-30 | The University Of Florida | Periodontal osseous defect repair |
| EP0263489A1 (en) * | 1986-10-06 | 1988-04-13 | Kuraray Co., Ltd. | Granular inorganic moldings and a process for production thereof |
| FR2606282A1 (fr) * | 1986-11-12 | 1988-05-13 | Ecole Nale Sup Ceramique Indle | Composition durcissable pour le comblement des cavites osseuses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981736A (en) * | 1973-05-23 | 1976-09-21 | Ernst Leitz G.M.B.H. | Biocompatible glass ceramic material |
| US3905047A (en) * | 1973-06-27 | 1975-09-16 | Posta Jr John J | Implantable ceramic bone prosthesis |
| DE2501683C3 (de) * | 1975-01-17 | 1979-11-29 | Ernst Leitz Wetzlar Gmbh, 6300 Wetzlar | Polymeres Verbundmaterial für prothetische Zwecke und Verfahren zu seiner Herstellung |
| DD219017A3 (de) * | 1982-02-26 | 1985-02-20 | Univ Schiller Jena | Maschinell bearbeitbare bioaktive glaskeramik |
| BE895229A (fr) * | 1982-12-02 | 1983-03-31 | Wallone Region | Materiaux bioreactifs |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| JPS63102762A (ja) * | 1986-10-20 | 1988-05-07 | 丸野 重雄 | 生体適合性複合体及びその製法 |
| JPS63242263A (ja) * | 1987-03-31 | 1988-10-07 | 東海カ−ボン株式会社 | 人工骨材 |
| JPS645940A (en) * | 1987-06-30 | 1989-01-10 | Lion Corp | Ceramic composite sintered compact and its production |
-
1989
- 1989-04-20 FR FR898905504A patent/FR2646084B1/fr not_active Expired - Fee Related
-
1990
- 1990-04-18 ES ES90420194T patent/ES2055386T5/es not_active Expired - Lifetime
- 1990-04-18 DK DK90420194.4T patent/DK0394152T3/da active
- 1990-04-18 EP EP90420194A patent/EP0394152B9/fr not_active Expired - Lifetime
- 1990-04-18 AT AT90420194T patent/ATE107519T1/de not_active IP Right Cessation
- 1990-04-18 DE DE69010066T patent/DE69010066T3/de not_active Expired - Fee Related
- 1990-04-19 CA CA002014940A patent/CA2014940C/fr not_active Expired - Fee Related
- 1990-04-19 DD DD90339901A patent/DD293728A5/de not_active IP Right Cessation
- 1990-04-19 BE BE9000433A patent/BE1005342A5/fr not_active IP Right Cessation
- 1990-04-19 US US07/511,303 patent/US5204106A/en not_active Expired - Lifetime
- 1990-04-20 JP JP2105141A patent/JPH03136664A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4159358A (en) * | 1977-05-19 | 1979-06-26 | Board Of Regents, State Of Florida | Method of bonding a bioglass to metal |
| EP0145210A2 (en) * | 1983-10-27 | 1985-06-19 | E.I. Du Pont De Nemours And Company | Support particles coated with precursors biologically active glass |
| EP0206726A2 (en) * | 1985-06-19 | 1986-12-30 | The University Of Florida | Periodontal osseous defect repair |
| EP0263489A1 (en) * | 1986-10-06 | 1988-04-13 | Kuraray Co., Ltd. | Granular inorganic moldings and a process for production thereof |
| FR2606282A1 (fr) * | 1986-11-12 | 1988-05-13 | Ecole Nale Sup Ceramique Indle | Composition durcissable pour le comblement des cavites osseuses |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0394152B9 (fr) | 2006-10-25 |
| DE69010066T2 (de) | 1995-03-02 |
| DE69010066T3 (de) | 2006-11-09 |
| ATE107519T1 (de) | 1994-07-15 |
| FR2646084A1 (fr) | 1990-10-26 |
| EP0394152A1 (fr) | 1990-10-24 |
| US5204106A (en) | 1993-04-20 |
| ES2055386T3 (es) | 1994-08-16 |
| DE69010066D1 (de) | 1994-07-28 |
| JPH03136664A (ja) | 1991-06-11 |
| CA2014940A1 (fr) | 1990-10-20 |
| JPH0587261B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1993-12-16 |
| FR2646084B1 (fr) | 1994-09-16 |
| ES2055386T5 (es) | 2006-11-16 |
| DD293728A5 (de) | 1991-09-12 |
| CA2014940C (fr) | 1995-05-16 |
| DK0394152T3 (da) | 1995-03-27 |
| EP0394152B2 (fr) | 2006-03-22 |
| EP0394152B1 (fr) | 1994-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BE1005342A5 (fr) | Materiau de restauration d'un defaut osseux par comblement par du tissu osseux. | |
| Schepers et al. | Bioactive glass particles of narrow size range for the treatment of oral bone defects: a 1–24 month experiment with several materials and particle sizes and size ranges | |
| EP0417018B1 (fr) | Matériau bioréactif pour prothèse ou implants composites | |
| EP0984902B1 (fr) | Procede de preparation d'un biomateriau a base d'hydroxyapatite, biomateriau obtenu et application chirurgicale ou dentaire | |
| RU2152778C1 (ru) | Препарат для уменьшения раздражения пульпы и/или укрепления структуры зуба | |
| EP1778306B1 (fr) | Bioverre poreux et procede de preparation | |
| EP2178805B1 (fr) | Verres bioactifs dopes en strontium | |
| WO1997047334A1 (fr) | Procede de preparation d'un materiau composite implantable, materiau obtenu, implant comprenant ce materiau et kit de mise en oeuvre | |
| EP1742676B1 (fr) | Composition pour ciment injectable, utile comme substitut osseux | |
| GB2539490A (en) | Method for the preparation of teeth coatings having morphogenetic activity | |
| US6228386B1 (en) | Compositions and methods to repair osseous defects | |
| CA2657529C (fr) | Compose phospho-calco-strontique et ses utilisations dans des ciments endodontiques | |
| EP2307064B1 (fr) | Biomateriaux a base de phosphate de calcium | |
| EP2331151B1 (fr) | Substitut osseux à base de bioverre poreux et de sulfate de calcium | |
| EP3458117B1 (fr) | Produit et procede pour la preparation d'une composition injectable, a base de chitosane et de bioverres, destinee a la regeneration du tissu osseux | |
| CN106265093A (zh) | 一种牙科修复材料及其制备方法 | |
| JPH0236684B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| PADOVAN et al. | This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
| Schepers et al. | Interfacial tissue response to bioactive glasses with reduced surface reactivity | |
| FR2728797A1 (fr) | Endoprothese avec revetement en calcite et procede d'obtention | |
| FR2883755A1 (fr) | Materiau implantable destine a etre colonise par un tissu, notamment un tissu osseux, et procede de fabrication de ce materiau |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: ORTHOVITA INC. Effective date: 20010430 |