BE1003113A5 - Procede de preparation de derives de nucleosides. - Google Patents

Procede de preparation de derives de nucleosides. Download PDF

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Publication number
BE1003113A5
BE1003113A5 BE9000544A BE9000544A BE1003113A5 BE 1003113 A5 BE1003113 A5 BE 1003113A5 BE 9000544 A BE9000544 A BE 9000544A BE 9000544 A BE9000544 A BE 9000544A BE 1003113 A5 BE1003113 A5 BE 1003113A5
Authority
BE
Belgium
Prior art keywords
preparation
dideoxynucleosides
nucleoside derivatives
derivatives
didehydro
Prior art date
Application number
BE9000544A
Other languages
English (en)
Inventor
Yusuke Amino
Hisao Iwagami
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of BE1003113A5 publication Critical patent/BE1003113A5/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des dérivés de 2',3'-didéshydro-2',3'-didésoxynucléosides qui sont des intermédiaires pour la synthèse de 2',3'-didésoxynucléosides utiles comme médicaments tels que des agent antiviraux, entre autres, sont obtenus par un nouveau procédé de préparation de dérivés de 2',3'-didéshydro-2',3'-didésoxynucléosides avec une haute pureté et un rendement élevé. Le procédé de l'invention est aussi un procédé général pour convertir les 1,2-diols en oléfines.
BE9000544A 1989-05-26 1990-05-23 Procede de preparation de derives de nucleosides. BE1003113A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1134186A JPH02311491A (ja) 1989-05-26 1989-05-26 ヌクレオシド誘導体の製造方法

Publications (1)

Publication Number Publication Date
BE1003113A5 true BE1003113A5 (fr) 1991-11-26

Family

ID=15122451

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000544A BE1003113A5 (fr) 1989-05-26 1990-05-23 Procede de preparation de derives de nucleosides.

Country Status (4)

Country Link
US (1) US5106962A (fr)
JP (1) JPH02311491A (fr)
BE (1) BE1003113A5 (fr)
FR (1) FR2647450B1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
ATE522497T1 (de) * 2003-01-09 2011-09-15 Ajinomoto Kk Verfahren zur herstellung eines glutaminsäurederivats, ein pyroglutaminsäurederivat und ein neues zwischenprodukt für die herstellung

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280104A (en) * 1964-04-13 1966-10-18 Syntex Corp 2', 3'-dideoxyribonucleoside and 2', 3'-dideoxyribonucleotide derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 106, no. 21, 17 octobre 1984, pages 6217-6220, American Chemical Society; R. MAIDAN et al.: "Application of multielectron charge relays in chemical and photochemical debromination processes. The role of induced disproportionation of N,N'-dioctyl-4,4'-bipyridinium radical cation in two-phase systems" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 28, no. 4, avril 1963, pages 936-941, American Chemical Society; J.J. FOX et al.: "Nucleosides. XVI. Further studies of anhydronucleosides" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 1, 11 janvier 1974, pages 30-38, American Chemical Society; T.C. JAIN et al.: "Reactions of 2-acyloxyisobutyryl halides with nucleosides. IV. A facile synthesis of 2',3'-unsaturated nucleosides using chromous acetate" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 9, 27 avril 1979, pages 1404-1409, American Chemical Society; T. ADACHI et al.: "Synthetic electrochemical studies on nucleosides. 1. Novel method for the synthesis of 2',3'-unsaturated nucleosides via electrolysis" *
TETRAHEDRON LETTERS, vol. 25, no. 4, 1984, pages 367-370, Pergamon Press Ltd, GB; M.J. ROBINS et al.: "A mild conversion of vicinal diols to alkenes. Efficient transformation of ribonucleosides into 2'-ene and 2',3'-dideoxynucleosides" *

Also Published As

Publication number Publication date
FR2647450B1 (fr) 1994-10-21
FR2647450A1 (fr) 1990-11-30
JPH02311491A (ja) 1990-12-27
US5106962A (en) 1992-04-21

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AJINOMOTO CO., INC.

Effective date: 19940531