BE1000626A3 - Procede pour l'augmentation de la concentration de l'hormone de croissance endogene dans le sang d'un mammifere. - Google Patents
Procede pour l'augmentation de la concentration de l'hormone de croissance endogene dans le sang d'un mammifere. Download PDFInfo
- Publication number
- BE1000626A3 BE1000626A3 BE8701473A BE8701473A BE1000626A3 BE 1000626 A3 BE1000626 A3 BE 1000626A3 BE 8701473 A BE8701473 A BE 8701473A BE 8701473 A BE8701473 A BE 8701473A BE 1000626 A3 BE1000626 A3 BE 1000626A3
- Authority
- BE
- Belgium
- Prior art keywords
- sep
- growth hormone
- grf
- administration
- mammal
- Prior art date
Links
- 108010051696 Growth Hormone Proteins 0.000 title claims abstract description 69
- 102000018997 Growth Hormone Human genes 0.000 title claims abstract description 69
- 239000000122 growth hormone Substances 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 19
- 241000124008 Mammalia Species 0.000 title claims abstract description 18
- 210000004369 blood Anatomy 0.000 title claims abstract description 12
- 239000008280 blood Substances 0.000 title claims abstract description 12
- 230000008569 process Effects 0.000 title description 2
- 241001465754 Metazoa Species 0.000 claims abstract description 29
- 241000283690 Bos taurus Species 0.000 claims description 20
- 241001494479 Pecora Species 0.000 claims description 13
- 235000013365 dairy product Nutrition 0.000 claims description 7
- 101710154918 Trigger factor Proteins 0.000 claims description 6
- 108010006025 bovine growth hormone Proteins 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 21
- 238000001802 infusion Methods 0.000 description 19
- 230000004044 response Effects 0.000 description 19
- 241000894007 species Species 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 9
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 description 8
- 101710142969 Somatoliberin Proteins 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 241000282887 Suidae Species 0.000 description 7
- 239000005556 hormone Substances 0.000 description 7
- 229940088597 hormone Drugs 0.000 description 7
- 238000001990 intravenous administration Methods 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 230000028327 secretion Effects 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000003094 microcapsule Substances 0.000 description 6
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 241000283707 Capra Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001408 amides Chemical group 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000000541 pulsatile effect Effects 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000002485 urinary effect Effects 0.000 description 3
- 241001631457 Cannula Species 0.000 description 2
- 206010056438 Growth hormone deficiency Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002844 continuous effect Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003016 hypothalamus Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 201000002528 pancreatic cancer Diseases 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 101000825768 Bos taurus Somatoliberin Proteins 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 235000010919 Copernicia prunifera Nutrition 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
- 241001315286 Damon Species 0.000 description 1
- 208000036829 Device dislocation Diseases 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- CAHKINHBCWCHCF-JTQLQIEISA-N N-acetyl-L-tyrosine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-JTQLQIEISA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 101000825739 Ovis aries Somatoliberin Proteins 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920001727 cellulose butyrate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 229960001682 n-acetyltyrosine Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94543786A | 1986-12-22 | 1986-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1000626A3 true BE1000626A3 (fr) | 1989-02-21 |
Family
ID=25483086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8701473A BE1000626A3 (fr) | 1986-12-22 | 1987-12-22 | Procede pour l'augmentation de la concentration de l'hormone de croissance endogene dans le sang d'un mammifere. |
Country Status (11)
Country | Link |
---|---|
JP (1) | JP2532117B2 (it) |
AU (1) | AU601532B2 (it) |
BE (1) | BE1000626A3 (it) |
CA (1) | CA1317222C (it) |
DE (1) | DE3743129C2 (it) |
FR (1) | FR2608430B1 (it) |
GB (1) | GB2198643B (it) |
HK (1) | HK35793A (it) |
IT (1) | IT1223542B (it) |
NZ (1) | NZ222982A (it) |
ZA (1) | ZA879528B (it) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486134B2 (en) * | 1999-09-17 | 2002-11-26 | Leadergene Limited | Gene treatment to enhance feed efficiency and growth rate of livestock |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3436819A1 (de) * | 1984-10-06 | 1986-04-17 | Hoechst Ag, 6230 Frankfurt | Arzneimittel mit grf-wirkung |
EP0212531A1 (en) * | 1985-08-12 | 1987-03-04 | Syntex (U.S.A.) Inc. | Bovine growth hormone releasing factor derivative |
-
1987
- 1987-12-17 CA CA000554603A patent/CA1317222C/en not_active Expired - Fee Related
- 1987-12-18 FR FR878717733A patent/FR2608430B1/fr not_active Expired
- 1987-12-18 GB GB8729492A patent/GB2198643B/en not_active Expired - Lifetime
- 1987-12-18 DE DE3743129A patent/DE3743129C2/de not_active Expired - Fee Related
- 1987-12-18 AU AU82700/87A patent/AU601532B2/en not_active Ceased
- 1987-12-18 ZA ZA879528A patent/ZA879528B/xx unknown
- 1987-12-18 NZ NZ222982A patent/NZ222982A/en unknown
- 1987-12-18 IT IT23101/87A patent/IT1223542B/it active
- 1987-12-18 JP JP62322618A patent/JP2532117B2/ja not_active Expired - Lifetime
- 1987-12-22 BE BE8701473A patent/BE1000626A3/fr not_active IP Right Cessation
-
1993
- 1993-04-15 HK HK357/93A patent/HK35793A/xx not_active IP Right Cessation
Non-Patent Citations (1)
Title |
---|
Néant. * |
Also Published As
Publication number | Publication date |
---|---|
AU8270087A (en) | 1988-06-23 |
JP2532117B2 (ja) | 1996-09-11 |
JPS63166833A (ja) | 1988-07-11 |
AU601532B2 (en) | 1990-09-13 |
IT8723101A0 (it) | 1987-12-18 |
GB2198643A (en) | 1988-06-22 |
FR2608430B1 (fr) | 1989-11-03 |
ZA879528B (en) | 1989-08-30 |
GB8729492D0 (en) | 1988-02-03 |
FR2608430A1 (fr) | 1988-06-24 |
HK35793A (en) | 1993-04-23 |
CA1317222C (en) | 1993-05-04 |
DE3743129C2 (de) | 1997-05-07 |
NZ222982A (en) | 1990-04-26 |
GB2198643B (en) | 1990-10-10 |
IT1223542B (it) | 1990-09-19 |
DE3743129A1 (de) | 1988-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69719360T2 (de) | Zusammensetzungen und methoden zur steigerung der darmfunktion | |
DE69737065T2 (de) | Insulin c-peptide | |
Moxley 3rd et al. | Acute effects of insulin-like growth factor I and insulin on glucose metabolism in vivo | |
CA1327310C (fr) | Procede pour augmenter la production laitiere chez les mammiferes et/ou accroitre le poids de leurs nouveaux-nes a la naissance et ameliorer la croissance post-natale | |
JPS60501504A (ja) | 成長ホルモン内の部分に構造的に関連する生物学的活性を有するペプチド類 | |
EP0289186A2 (en) | Process for increasing the growth rate and enhancing the feed efficiency of meat producing livestock | |
Van Raaij et al. | Effect of arterially infused catecholamines and insulin on plasma glucose and free fatty acids in carp | |
Crim | Methods for acute and chronic hormone administration in fish | |
Olivereau et al. | Action de la prolactine chez l'anguille intacte et hypophysectomisée | |
CN102946897B (zh) | 糖尿病的血管并发症的治疗 | |
Abe et al. | Stimulation by bombesin of immunoreactive somatostatin release into rat hypophysial portal blood | |
BE1000626A3 (fr) | Procede pour l'augmentation de la concentration de l'hormone de croissance endogene dans le sang d'un mammifere. | |
Carolsfeld et al. | Induced sexual maturation of herring using GnRH ‘quick-release’cholesterol pellets | |
Widmaier et al. | Interactions between oxytocin, glucagon and glucose in normal and streptozotocin-induced diabetic rats | |
Thompson et al. | Chronic effects of nicotine on rat gastric secretion | |
US5691377A (en) | Use of N-methyl-aspartic acid for enhancing growth and altering body composition | |
JP4899570B2 (ja) | カカオバター油性製剤を用いたLHRHaの注射投与によるマハタ親魚の成熟・排卵誘導法 | |
Pawlik et al. | Role of tachykinins in the control of pancreatic secretion and circulation | |
EP0438929B1 (en) | A composition based on somatotropin for controlling the sea water adaptation of farmed salmonids | |
DK170758B1 (da) | Fremgangsmåde til forøgelse af koncentrationen af endogent væksthormon i blodet hos et husdyr valgt blandt kvæg, grise, får, geder, kameler og heste | |
EP1359914B1 (fr) | Nouvelle application therapeutique d'un derive de la thienylcyclohexylamine pour traiter la douleur | |
FR2561522A1 (fr) | Solution injectable, notamment pour le traitement de la cetose et son procede de preparation | |
Bloom et al. | Effects of certain metabolites on pancreatic endocrine responses to stimulation of the vagus nerves in conscious calves. | |
Dubreuil et al. | The use of pigs as an animal model to evaluate the efficacy, potency and specificity of two growth hormone releasing factor analogues | |
FR2580174A1 (fr) | Procede ameliore pour augmenter l'activite sexuelle d'oiseaux et de mammiferes domestiques utiles et pour preparer des spermatozoides convenant a la reproduction de ces oiseaux et mammiferes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: ELI LILLY AND CY Effective date: 20001231 |