AU601532B2 - Increasing endogenous growth hormone - Google Patents
Increasing endogenous growth hormone Download PDFInfo
- Publication number
- AU601532B2 AU601532B2 AU82700/87A AU8270087A AU601532B2 AU 601532 B2 AU601532 B2 AU 601532B2 AU 82700/87 A AU82700/87 A AU 82700/87A AU 8270087 A AU8270087 A AU 8270087A AU 601532 B2 AU601532 B2 AU 601532B2
- Authority
- AU
- Australia
- Prior art keywords
- growth hormone
- grf
- administration
- mammal
- releasing factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 108010051696 Growth Hormone Proteins 0.000 title claims description 62
- 102000018997 Growth Hormone Human genes 0.000 title claims description 62
- 239000000122 growth hormone Substances 0.000 title claims description 62
- 101710142969 Somatoliberin Proteins 0.000 claims description 100
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims description 99
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims description 99
- 241001465754 Metazoa Species 0.000 claims description 28
- 241000283690 Bos taurus Species 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 17
- 241000124008 Mammalia Species 0.000 claims description 16
- 241001494479 Pecora Species 0.000 claims description 12
- 235000013365 dairy product Nutrition 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 101000825768 Bos taurus Somatoliberin Proteins 0.000 claims description 3
- 230000006651 lactation Effects 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 20
- 230000004044 response Effects 0.000 description 19
- 238000001802 infusion Methods 0.000 description 17
- 241000894007 species Species 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 11
- 230000008901 benefit Effects 0.000 description 10
- 238000001990 intravenous administration Methods 0.000 description 9
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 241000282887 Suidae Species 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 241000282414 Homo sapiens Species 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000005556 hormone Substances 0.000 description 6
- 229940088597 hormone Drugs 0.000 description 6
- 230000028327 secretion Effects 0.000 description 6
- 235000013336 milk Nutrition 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000000541 pulsatile effect Effects 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000035611 feeding Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000003094 microcapsule Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000002485 urinary effect Effects 0.000 description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000003016 hypothalamus Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 201000002528 pancreatic cancer Diseases 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241001315286 Damon Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 1
- CAHKINHBCWCHCF-JTQLQIEISA-N N-acetyl-L-tyrosine Chemical compound CC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-JTQLQIEISA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 108010006025 bovine growth hormone Proteins 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920001727 cellulose butyrate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000000332 continued effect Effects 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001667 episodic effect Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 229960001682 n-acetyltyrosine Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920000260 silastic Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94543786A | 1986-12-22 | 1986-12-22 | |
| US945437 | 1986-12-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8270087A AU8270087A (en) | 1988-06-23 |
| AU601532B2 true AU601532B2 (en) | 1990-09-13 |
Family
ID=25483086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU82700/87A Ceased AU601532B2 (en) | 1986-12-22 | 1987-12-18 | Increasing endogenous growth hormone |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JP2532117B2 (it) |
| AU (1) | AU601532B2 (it) |
| BE (1) | BE1000626A3 (it) |
| CA (1) | CA1317222C (it) |
| DE (1) | DE3743129C2 (it) |
| FR (1) | FR2608430B1 (it) |
| GB (1) | GB2198643B (it) |
| HK (1) | HK35793A (it) |
| IT (1) | IT1223542B (it) |
| NZ (1) | NZ222982A (it) |
| ZA (1) | ZA879528B (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486134B2 (en) * | 1999-09-17 | 2002-11-26 | Leadergene Limited | Gene treatment to enhance feed efficiency and growth rate of livestock |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4833285A (en) * | 1984-10-06 | 1986-04-10 | Hoechst Aktiengesellschaft | Medicaments with GRF activity |
| AU6104686A (en) * | 1985-08-12 | 1987-02-19 | Syntex (U.S.A.) Inc. | Bovine growth hormone releasing factor perivative |
-
1987
- 1987-12-17 CA CA000554603A patent/CA1317222C/en not_active Expired - Fee Related
- 1987-12-18 FR FR878717733A patent/FR2608430B1/fr not_active Expired
- 1987-12-18 NZ NZ222982A patent/NZ222982A/en unknown
- 1987-12-18 ZA ZA879528A patent/ZA879528B/xx unknown
- 1987-12-18 DE DE3743129A patent/DE3743129C2/de not_active Expired - Fee Related
- 1987-12-18 GB GB8729492A patent/GB2198643B/en not_active Expired - Lifetime
- 1987-12-18 IT IT23101/87A patent/IT1223542B/it active
- 1987-12-18 JP JP62322618A patent/JP2532117B2/ja not_active Expired - Lifetime
- 1987-12-18 AU AU82700/87A patent/AU601532B2/en not_active Ceased
- 1987-12-22 BE BE8701473A patent/BE1000626A3/fr not_active IP Right Cessation
-
1993
- 1993-04-15 HK HK357/93A patent/HK35793A/xx not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4833285A (en) * | 1984-10-06 | 1986-04-10 | Hoechst Aktiengesellschaft | Medicaments with GRF activity |
| AU6104686A (en) * | 1985-08-12 | 1987-02-19 | Syntex (U.S.A.) Inc. | Bovine growth hormone releasing factor perivative |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA879528B (en) | 1989-08-30 |
| NZ222982A (en) | 1990-04-26 |
| AU8270087A (en) | 1988-06-23 |
| JPS63166833A (ja) | 1988-07-11 |
| FR2608430B1 (fr) | 1989-11-03 |
| FR2608430A1 (fr) | 1988-06-24 |
| GB2198643A (en) | 1988-06-22 |
| JP2532117B2 (ja) | 1996-09-11 |
| GB2198643B (en) | 1990-10-10 |
| IT1223542B (it) | 1990-09-19 |
| IT8723101A0 (it) | 1987-12-18 |
| GB8729492D0 (en) | 1988-02-03 |
| BE1000626A3 (fr) | 1989-02-21 |
| DE3743129A1 (de) | 1988-06-30 |
| DE3743129C2 (de) | 1997-05-07 |
| HK35793A (en) | 1993-04-23 |
| CA1317222C (en) | 1993-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |