AU9206798A - Pyrrolidine and piperidine modulators of chemokine receptor activity - Google Patents
Pyrrolidine and piperidine modulators of chemokine receptor activity Download PDFInfo
- Publication number
- AU9206798A AU9206798A AU92067/98A AU9206798A AU9206798A AU 9206798 A AU9206798 A AU 9206798A AU 92067/98 A AU92067/98 A AU 92067/98A AU 9206798 A AU9206798 A AU 9206798A AU 9206798 A AU9206798 A AU 9206798A
- Authority
- AU
- Australia
- Prior art keywords
- pct
- phenyl
- alkyl
- 3alkyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 O=C(c1ccc(C(F)(F)F)cc1)N(C[C@@]1CN(CC2)CCC2c2ccccc2)C[C@@]1*1ccccc1 Chemical compound O=C(c1ccc(C(F)(F)F)cc1)N(C[C@@]1CN(CC2)CCC2c2ccccc2)C[C@@]1*1ccccc1 0.000 description 2
- ZHCOEWDHXCZKHB-FLBNQQOGSA-N C(C(CN(Cc1ccccc1)C1)[C@H]1c1cccc(-c(cc2)ccc2C2=CCN(CC(CN(Cc3ccccc3)C3)[C@H]3c3ccccc3)CC2)c1)N(CC1)CCN1c1ccccc1 Chemical compound C(C(CN(Cc1ccccc1)C1)[C@H]1c1cccc(-c(cc2)ccc2C2=CCN(CC(CN(Cc3ccccc3)C3)[C@H]3c3ccccc3)CC2)c1)N(CC1)CCN1c1ccccc1 ZHCOEWDHXCZKHB-FLBNQQOGSA-N 0.000 description 1
- AAYOIQDVJMEQDT-UHFFFAOYSA-N CC(C)OC(N(CC1CCCCC1)C1CCNCC1)=O Chemical compound CC(C)OC(N(CC1CCCCC1)C1CCNCC1)=O AAYOIQDVJMEQDT-UHFFFAOYSA-N 0.000 description 1
- RHTAHFVABLDZIF-NNBQYGFHSA-N CCC(CN(Cc1ccccc1)C1)[C@H]1c1ccccc1 Chemical compound CCC(CN(Cc1ccccc1)C1)[C@H]1c1ccccc1 RHTAHFVABLDZIF-NNBQYGFHSA-N 0.000 description 1
- IKYRCNWZCWOFCS-LBNVMWSVSA-N CCOC(C1CCN(C[C@@H](CN(C2)C(c3cccc4c3cccc4)=O)[C@H]2c2ccccc2)CC1)=O Chemical compound CCOC(C1CCN(C[C@@H](CN(C2)C(c3cccc4c3cccc4)=O)[C@H]2c2ccccc2)CC1)=O IKYRCNWZCWOFCS-LBNVMWSVSA-N 0.000 description 1
- XCFIZQYBDAGEHV-SVOUTRCYSA-N O=C(C1(CC2CC3C4)C23C4C1)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)C[C@@H]1c1ccccc1 Chemical compound O=C(C1(CC2CC3C4)C23C4C1)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)C[C@@H]1c1ccccc1 XCFIZQYBDAGEHV-SVOUTRCYSA-N 0.000 description 1
- LAVZSFUALWGHAZ-MIXNXMPVSA-N O=C(C1c2ccccc2-c2c1cccc2)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)CC1c1ccccc1 Chemical compound O=C(C1c2ccccc2-c2c1cccc2)N(C[C@@H]1CN(CC2)CCC2c2ccccc2)CC1c1ccccc1 LAVZSFUALWGHAZ-MIXNXMPVSA-N 0.000 description 1
- IPKOZQYLISCSQP-SFCXHYMASA-N O=C(c(cc1)ccc1-c1ccccc1)N(C[C@@H]1CCN(CC2)CCC2c2ccccc2)CC1c1ccccc1 Chemical compound O=C(c(cc1)ccc1-c1ccccc1)N(C[C@@H]1CCN(CC2)CCC2c2ccccc2)CC1c1ccccc1 IPKOZQYLISCSQP-SFCXHYMASA-N 0.000 description 1
- DCIFTXQVCBUFRT-XOGXXFMMSA-N O=C(c1cccc2c1-c1ccccc1C2)N(C[C@@H]1CN(CC2)CCC2C2C=CC=CC2)C[C@@H]1c1ccccc1 Chemical compound O=C(c1cccc2c1-c1ccccc1C2)N(C[C@@H]1CN(CC2)CCC2C2C=CC=CC2)C[C@@H]1c1ccccc1 DCIFTXQVCBUFRT-XOGXXFMMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5774397P | 1997-08-28 | 1997-08-28 | |
US60057743 | 1997-08-28 | ||
GB9801009 | 1998-01-16 | ||
GBGB9801009.3A GB9801009D0 (en) | 1998-01-16 | 1998-01-16 | Pyrrolidine and piperidine modulators of chemokine receptor activity |
PCT/US1998/017755 WO1999009984A1 (fr) | 1997-08-28 | 1998-08-27 | Modulateurs de pyrrolidine et de piperidine de l'activite du recepteur de chemokine |
Publications (1)
Publication Number | Publication Date |
---|---|
AU9206798A true AU9206798A (en) | 1999-03-16 |
Family
ID=26312970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU92067/98A Abandoned AU9206798A (en) | 1997-08-28 | 1998-08-27 | Pyrrolidine and piperidine modulators of chemokine receptor activity |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1009405A4 (fr) |
JP (1) | JP2001526178A (fr) |
AU (1) | AU9206798A (fr) |
CA (1) | CA2298813A1 (fr) |
WO (1) | WO1999009984A1 (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
AU2056800A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
US7217714B1 (en) | 1998-12-23 | 2007-05-15 | Agouron Pharmaceuticals, Inc. | CCR5 modulators |
EP1013276A1 (fr) | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalcanes comme modulateurs de CCR5 |
PE20001420A1 (es) | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
AU3389300A (en) * | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
WO2000051609A1 (fr) * | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | Modulateurs de l'activite recepteur des chimiokines, a base de pyrrolidine a substitution 3-alkyle |
US6303593B1 (en) * | 1999-03-02 | 2001-10-16 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
US6248755B1 (en) * | 1999-04-06 | 2001-06-19 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6265434B1 (en) * | 1999-04-06 | 2001-07-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6399619B1 (en) * | 1999-04-06 | 2002-06-04 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
US6498161B1 (en) | 1999-04-06 | 2002-12-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
GB9912701D0 (en) * | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
AU5328500A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
AU5469400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
WO2000076513A1 (fr) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Modulateurs cyclopentyliques de l'activite du recepteur de la chimiokine |
ATE344242T1 (de) * | 1999-06-11 | 2006-11-15 | Merck & Co Inc | N-cyclopentylmodulatoren der chemokine rezeptoraktivität |
WO2000076514A1 (fr) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Modulateurs de cyclopentyle de l'activite du recepteur de chimiokine |
US6358979B1 (en) | 1999-06-11 | 2002-03-19 | Merck & Co., Inc. | N-cyclopentyl modulators of chemokine receptor activity |
AU5473400A (en) | 1999-06-11 | 2001-01-02 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
WO2001064216A1 (fr) * | 2000-02-28 | 2001-09-07 | Merck & Co., Inc. | Modulateurs 4-alkyl piperidinyl pyrrolidine d'activite de recepteur de chemokine |
CA2413245A1 (fr) | 2000-06-30 | 2002-01-10 | Bristol-Myers Squibb Pharma Company | N-ureidoheterocycloaklyl-piperidines utilises comme modulateurs de l'activite du recepteur de la chimiokine |
US6531484B2 (en) | 2000-10-11 | 2003-03-11 | Merck & Co., Inc. | Pyrrolidine modulators of CCR5 chemokine receptor activity |
ATE341327T1 (de) | 2001-02-28 | 2006-10-15 | Merck & Co Inc | Acylierte piperidin-derivate als melanocortin-4- rezeptor-agonisten |
AU2002258414B2 (en) * | 2001-02-28 | 2005-12-15 | Merck Sharp & Dohme Corp. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
MXPA03008109A (es) * | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Moduladores de la actividad de receptores de quimiocinas. |
GB0108099D0 (en) * | 2001-03-30 | 2001-05-23 | Hoffmann La Roche | Aminopiperidine derivatives |
PT1598340E (pt) * | 2001-04-18 | 2009-04-13 | Euro Celtique Sa | Derivados de 1-(4-piperidinil)-1,3-di-hidro-2h-benzoxazole- 2-ona e compostos relacionados como análogos de nociceptina e ligandos orl1 para o tratamento da dor |
JP4336196B2 (ja) | 2001-07-18 | 2009-09-30 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作動薬としての架橋ピペリジン誘導体 |
DK1531822T3 (da) | 2002-06-12 | 2009-12-07 | Chemocentryx Inc | 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
AU2003268493A1 (en) | 2002-09-11 | 2004-04-30 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
EP1633343A1 (fr) | 2003-05-30 | 2006-03-15 | Neuromed Technologies, Inc. | 3-aminomethyle-pyrrolidines comme inhibiteurs de canaux calciques de type n |
EP1786815B1 (fr) | 2003-09-10 | 2011-08-24 | Virochem Pharma Inc. | Composes spiro et procedes pour la modulation de l'activite de recepteur de chimiokine |
GB0328906D0 (en) | 2003-12-12 | 2004-01-14 | Syngenta Participations Ag | Chemical compounds |
WO2005084667A1 (fr) | 2004-03-03 | 2005-09-15 | Chemocentryx, Inc. | Hétérocycles d'azote bicycliques et pontés |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
EP2364705A3 (fr) * | 2004-08-19 | 2012-04-04 | Vertex Pharmaceuticals Incorporated | Modulateurs des récepteurs muscariniques |
NZ555770A (en) * | 2004-12-24 | 2010-12-24 | Astrazeneca Ab | Heterocyclic piperazine-carboxamide compounds as CCR2B antagonists |
US7635698B2 (en) | 2004-12-29 | 2009-12-22 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
US7880002B2 (en) | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
JP2008526840A (ja) * | 2005-01-06 | 2008-07-24 | アストラゼネカ アクチボラグ | 新規化合物 |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
GB0525957D0 (en) | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
KR20080087841A (ko) * | 2005-12-22 | 2008-10-01 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린 수용체의 조절제 |
US8129411B2 (en) | 2005-12-30 | 2012-03-06 | Novartis Ag | Organic compounds |
US7351706B2 (en) | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
KR20080098070A (ko) * | 2006-02-22 | 2008-11-06 | 버텍스 파마슈티칼스 인코포레이티드 | 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘 |
ATE533744T1 (de) | 2006-05-19 | 2011-12-15 | Wyeth Llc | N-benzoypyrrolidin-3-ylamine als histamin-3 antagonisten |
US7727978B2 (en) | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
BRPI0813900A2 (pt) | 2007-06-25 | 2014-12-30 | Novartis Ag | Derivados de n5-(2-etoxietil)-n3-(2-piridinil)-3,5-piperidinodicarboxa mida para uso como inibidores de renina |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
JP5580741B2 (ja) | 2008-09-19 | 2014-08-27 | 武田薬品工業株式会社 | 含窒素複素環化合物およびその用途 |
WO2024020101A1 (fr) * | 2022-07-21 | 2024-01-25 | The Regents Of The University Of California | Composés inhibiteurs de la prostaglandine e synthase 3 (ptges3) |
CN115448864B (zh) * | 2022-08-26 | 2023-12-22 | 上海方予健康医药科技有限公司 | 3-氟-3-(1-羟乙基)吡咯烷-1-羧酸叔丁酯的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635510A (en) * | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
-
1998
- 1998-08-27 WO PCT/US1998/017755 patent/WO1999009984A1/fr not_active Application Discontinuation
- 1998-08-27 JP JP2000507374A patent/JP2001526178A/ja active Pending
- 1998-08-27 AU AU92067/98A patent/AU9206798A/en not_active Abandoned
- 1998-08-27 CA CA002298813A patent/CA2298813A1/fr not_active Abandoned
- 1998-08-27 EP EP98944548A patent/EP1009405A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2298813A1 (fr) | 1999-03-04 |
JP2001526178A (ja) | 2001-12-18 |
EP1009405A4 (fr) | 2001-05-09 |
EP1009405A1 (fr) | 2000-06-21 |
WO1999009984A1 (fr) | 1999-03-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |