AU8864398A - Plasminogen activator with enhanced zymogenic power and reduced fibrin linking - Google Patents

Plasminogen activator with enhanced zymogenic power and reduced fibrin linking

Info

Publication number
AU8864398A
AU8864398A AU88643/98A AU8864398A AU8864398A AU 8864398 A AU8864398 A AU 8864398A AU 88643/98 A AU88643/98 A AU 88643/98A AU 8864398 A AU8864398 A AU 8864398A AU 8864398 A AU8864398 A AU 8864398A
Authority
AU
Australia
Prior art keywords
zymogenic
linking
enhanced
power
plasminogen activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU88643/98A
Other languages
English (en)
Inventor
Wolfram Bode
Richard Engh
Stephan Fischer
Robert Huber
Ulrich Kohnert
Martin Renatus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU8864398A publication Critical patent/AU8864398A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU88643/98A 1997-08-13 1998-08-07 Plasminogen activator with enhanced zymogenic power and reduced fibrin linking Abandoned AU8864398A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97113936 1997-08-13
EP97113936 1997-08-13
PCT/EP1998/005012 WO1999009184A1 (fr) 1997-08-13 1998-08-07 Activateur du plasminogene a pouvoir zymogene ameliore et a liaison a la fibrine reduite

Publications (1)

Publication Number Publication Date
AU8864398A true AU8864398A (en) 1999-03-08

Family

ID=8227205

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88643/98A Abandoned AU8864398A (en) 1997-08-13 1998-08-07 Plasminogen activator with enhanced zymogenic power and reduced fibrin linking

Country Status (2)

Country Link
AU (1) AU8864398A (fr)
WO (1) WO1999009184A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113416724B (zh) * 2021-06-25 2023-05-23 福州大学 一种组织型纤溶酶原激活剂的重组蛋白及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
EP0796323A1 (fr) * 1994-12-06 1997-09-24 Roche Diagnostics GmbH Utilisation du domaine protease de l'activateur plasminogene humain dans le traitement de maladies thromboemboliques
CN1244894A (zh) * 1996-11-12 2000-02-16 斯克里普斯研究所 组织型纤溶酶原活化剂(t－PA)变体:组合物及使用方法

Also Published As

Publication number Publication date
WO1999009184A1 (fr) 1999-02-25

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase