AU781552B2 - Diaryl piperidyl pyrrole derivatives as antiprotozoal agents - Google Patents

Diaryl piperidyl pyrrole derivatives as antiprotozoal agents Download PDF

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Publication number
AU781552B2
AU781552B2 AU15904/01A AU1590401A AU781552B2 AU 781552 B2 AU781552 B2 AU 781552B2 AU 15904/01 A AU15904/01 A AU 15904/01A AU 1590401 A AU1590401 A AU 1590401A AU 781552 B2 AU781552 B2 AU 781552B2
Authority
AU
Australia
Prior art keywords
compound
optionally substituted
alkyl
groups selected
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU15904/01A
Other languages
English (en)
Other versions
AU1590401A (en
Inventor
Tesfaye Biftu
Danqing D. Feng
Michael H. Fisher
Gui-Bai Liang
Mitree M. Ponpipom
Xiaoxia Qian
Matthew J. Wyvratt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU1590401A publication Critical patent/AU1590401A/en
Application granted granted Critical
Publication of AU781552B2 publication Critical patent/AU781552B2/en
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: MERCK & CO., INC.
Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP & DOHME CORP. Request to Amend Deed and Register Assignors: MERCK SHARP & DOHME CORP.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU15904/01A 1999-11-12 2000-11-09 Diaryl piperidyl pyrrole derivatives as antiprotozoal agents Ceased AU781552B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16514299P 1999-11-12 1999-11-12
US60/165142 1999-11-12
PCT/US2000/030747 WO2001034149A1 (en) 1999-11-12 2000-11-09 Diaryl piperidyl pyrrole derivatives as antiprotozoal agents

Publications (2)

Publication Number Publication Date
AU1590401A AU1590401A (en) 2001-06-06
AU781552B2 true AU781552B2 (en) 2005-05-26

Family

ID=22597609

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15904/01A Ceased AU781552B2 (en) 1999-11-12 2000-11-09 Diaryl piperidyl pyrrole derivatives as antiprotozoal agents

Country Status (11)

Country Link
US (2) US6291480B1 (enExample)
EP (1) EP1278520B1 (enExample)
JP (1) JP4722360B2 (enExample)
AT (1) ATE318600T1 (enExample)
AU (1) AU781552B2 (enExample)
CA (1) CA2390100C (enExample)
DE (1) DE60026350T2 (enExample)
ES (1) ES2257336T3 (enExample)
NZ (1) NZ518718A (enExample)
WO (1) WO2001034149A1 (enExample)
ZA (1) ZA200203685B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1596101A (en) * 1999-11-12 2001-06-06 Merck & Co., Inc. Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
JP4435563B2 (ja) * 2001-07-10 2010-03-17 バイオジェン アイデック インク アポトーシスプロセスの阻害および細胞性能の改善
US7375105B2 (en) 2001-09-05 2008-05-20 Smithkline Beecham P.L.C. Pyridine substituted furan derivatives as Raf kinase inhibitors
RU2006100301A (ru) * 2003-06-11 2006-07-10 Санкио Компани Лимитед (JP) Соединение циклического третичного амина
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US9943500B2 (en) * 2013-02-08 2018-04-17 Luoda Pharma Pty Ltd Methods of treating topical microbial infections
RU2659205C1 (ru) * 2017-06-01 2018-06-28 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Способ профилактики кокцидиоза цыплят-бройлеров при выращивании их на мясо
BE1028700B1 (nl) * 2020-10-13 2022-05-16 Poulpharm Bvba Werkwijze voor het testen van de efficiëntie van anti-parasitaire (coccidiose) middelen bij pluimvee en konijnen
WO2025085377A1 (en) * 2023-10-16 2025-04-24 Zoetis Services Llc Use of zoalene in livestock
WO2025171002A1 (en) * 2024-02-05 2025-08-14 Elanco Us Inc. Multi-layered granule therapeutics

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016426A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
AU3994795A (en) * 1994-12-06 1996-06-26 Nippon Soda Co., Ltd. Pyridylpyrrole compounds, process for production, and agrohorticultural bactericide
JP3294616B2 (ja) * 1995-08-10 2002-06-24 メルク エンド カンパニー インコーポレーテッド ２−置換アリールピロール、このような化合物を含む組成物及び使用方法
JPH09194477A (ja) * 1996-01-18 1997-07-29 Nippon Soda Co Ltd 新規なピリジルピロール化合物、製法および農園芸用殺菌剤
WO1997048725A1 (en) * 1996-06-21 1997-12-24 Peptech Limited Novel peptides for prevention and treatment of infection
JP2000080094A (ja) * 1998-07-02 2000-03-21 Sankyo Co Ltd ５員ヘテロアリ―ル化合物
JP2001010957A (ja) * 1999-04-28 2001-01-16 Sankyo Co Ltd 肝障害の予防または抑制剤
WO2000066124A1 (fr) * 1999-04-28 2000-11-09 Sankyo Company, Limited Agents preventifs ou inhibiteurs destines a une hepatopathie

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997016426A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
AU4395399A (en) * 1998-07-02 2000-01-24 Sankyo Company Limited Five-membered heteroaryl compounds

Also Published As

Publication number Publication date
EP1278520B1 (en) 2006-03-01
CA2390100C (en) 2010-01-05
EP1278520A4 (en) 2003-05-02
DE60026350T2 (de) 2006-11-09
ZA200203685B (en) 2003-06-05
US6384052B1 (en) 2002-05-07
EP1278520A1 (en) 2003-01-29
US6291480B1 (en) 2001-09-18
CA2390100A1 (en) 2001-05-17
NZ518718A (en) 2004-03-26
WO2001034149A1 (en) 2001-05-17
DE60026350D1 (de) 2006-04-27
JP4722360B2 (ja) 2011-07-13
AU1590401A (en) 2001-06-06
ATE318600T1 (de) 2006-03-15
JP2003527336A (ja) 2003-09-16
ES2257336T3 (es) 2006-08-01

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired