AU780554B2 - Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition - Google Patents

Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition Download PDF

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Publication number
AU780554B2
AU780554B2 AU21954/01A AU2195401A AU780554B2 AU 780554 B2 AU780554 B2 AU 780554B2 AU 21954/01 A AU21954/01 A AU 21954/01A AU 2195401 A AU2195401 A AU 2195401A AU 780554 B2 AU780554 B2 AU 780554B2
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AU
Australia
Prior art keywords
nitrogen
alkyl
atoms
optionally
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21954/01A
Other languages
English (en)
Other versions
AU2195401A (en
Inventor
Helen Jane Bryant
Mark Stuart Chambers
Philip Jones
Angus Murray Macleod
Robert James Maxey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2195401A publication Critical patent/AU2195401A/en
Application granted granted Critical
Publication of AU780554B2 publication Critical patent/AU780554B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU21954/01A 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition Ceased AU780554B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9929569 1999-12-14
GBGB9929569.3A GB9929569D0 (en) 1999-12-14 1999-12-14 Therapeutic agents
PCT/GB2000/004752 WO2001044250A1 (en) 1999-12-14 2000-12-11 SUBSTITUTED 1,2,3-TRIAZOLO[1,5-a]QUINAZOLINES FOR ENHANCING COGNITION

Publications (2)

Publication Number Publication Date
AU2195401A AU2195401A (en) 2001-06-25
AU780554B2 true AU780554B2 (en) 2005-03-24

Family

ID=10866311

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21954/01A Ceased AU780554B2 (en) 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition

Country Status (7)

Country Link
US (1) US7144887B2 (https=)
EP (1) EP1242423A1 (https=)
JP (1) JP2003516994A (https=)
AU (1) AU780554B2 (https=)
CA (1) CA2392955A1 (https=)
GB (1) GB9929569D0 (https=)
WO (1) WO2001044250A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
MX2011000755A (es) * 2008-07-28 2011-02-24 Hoffmann La Roche Derivados de diazepan y piperazina moduladores de receptores de quimiocina.
WO2012068149A1 (en) * 2010-11-15 2012-05-24 Agenebio, Inc. Benzodiazepine derivatives, compositions and methods for treating cognitive impairment
EP3034079B1 (en) 2010-11-15 2018-01-10 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
RU2014150494A (ru) * 2012-05-30 2016-07-20 Ф. Хоффманн-Ля Рош Аг Пирролидиногетероциклы
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6987384B2 (ja) 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
CN107344937A (zh) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 三唑并[1,5-a]喹唑啉类衍生物、其制备方法、药物组合物和用途
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI81350C (fi) * 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
DE19617862A1 (de) 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2194205T3 (es) * 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
EP0986562B1 (en) * 1997-05-08 2002-08-07 MERCK SHARP & DOHME LTD. Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
AU2195401A (en) 2001-06-25
JP2003516994A (ja) 2003-05-20
EP1242423A1 (en) 2002-09-25
CA2392955A1 (en) 2001-06-21
US7144887B2 (en) 2006-12-05
WO2001044250A1 (en) 2001-06-21
GB9929569D0 (en) 2000-02-09
US20030125333A1 (en) 2003-07-03

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