CA2392955A1 - Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition - Google Patents

Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition Download PDF

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Publication number
CA2392955A1
CA2392955A1 CA002392955A CA2392955A CA2392955A1 CA 2392955 A1 CA2392955 A1 CA 2392955A1 CA 002392955 A CA002392955 A CA 002392955A CA 2392955 A CA2392955 A CA 2392955A CA 2392955 A1 CA2392955 A1 CA 2392955A1
Authority
CA
Canada
Prior art keywords
nitrogen
atoms
4alkyl
optionally
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002392955A
Other languages
English (en)
French (fr)
Inventor
Helen Jane Bryant
Mark Stuart Chambers
Philip Jones
Angus Murray Macleod
Robert James Maxey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2392955A1 publication Critical patent/CA2392955A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002392955A 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition Abandoned CA2392955A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9929569.3A GB9929569D0 (en) 1999-12-14 1999-12-14 Therapeutic agents
GB9929569.3 1999-12-14
PCT/GB2000/004752 WO2001044250A1 (en) 1999-12-14 2000-12-11 SUBSTITUTED 1,2,3-TRIAZOLO[1,5-a]QUINAZOLINES FOR ENHANCING COGNITION

Publications (1)

Publication Number Publication Date
CA2392955A1 true CA2392955A1 (en) 2001-06-21

Family

ID=10866311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002392955A Abandoned CA2392955A1 (en) 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition

Country Status (7)

Country Link
US (1) US7144887B2 (https=)
EP (1) EP1242423A1 (https=)
JP (1) JP2003516994A (https=)
AU (1) AU780554B2 (https=)
CA (1) CA2392955A1 (https=)
GB (1) GB9929569D0 (https=)
WO (1) WO2001044250A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
MX2011000755A (es) * 2008-07-28 2011-02-24 Hoffmann La Roche Derivados de diazepan y piperazina moduladores de receptores de quimiocina.
WO2012068149A1 (en) * 2010-11-15 2012-05-24 Agenebio, Inc. Benzodiazepine derivatives, compositions and methods for treating cognitive impairment
EP3034079B1 (en) 2010-11-15 2018-01-10 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
RU2014150494A (ru) * 2012-05-30 2016-07-20 Ф. Хоффманн-Ля Рош Аг Пирролидиногетероциклы
EP3083569B1 (en) 2013-12-20 2022-01-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
JP6987384B2 (ja) 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
CN107344937A (zh) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 三唑并[1,5-a]喹唑啉类衍生物、其制备方法、药物组合物和用途
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI81350C (fi) * 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
DE19617862A1 (de) 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2194205T3 (es) * 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
EP0986562B1 (en) * 1997-05-08 2002-08-07 MERCK SHARP & DOHME LTD. Substituted 1,2,4-triazolo 3,4-a]phthalazine derivatives as gaba alpha 5 ligands
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
AU2195401A (en) 2001-06-25
JP2003516994A (ja) 2003-05-20
EP1242423A1 (en) 2002-09-25
US7144887B2 (en) 2006-12-05
WO2001044250A1 (en) 2001-06-21
AU780554B2 (en) 2005-03-24
GB9929569D0 (en) 2000-02-09
US20030125333A1 (en) 2003-07-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued