AU780554B2 - Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition - Google Patents

Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition Download PDF

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Publication number
AU780554B2
AU780554B2 AU21954/01A AU2195401A AU780554B2 AU 780554 B2 AU780554 B2 AU 780554B2 AU 21954/01 A AU21954/01 A AU 21954/01A AU 2195401 A AU2195401 A AU 2195401A AU 780554 B2 AU780554 B2 AU 780554B2
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AU
Australia
Prior art keywords
nitrogen
alkyl
atoms
optionally
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21954/01A
Other languages
English (en)
Other versions
AU2195401A (en
Inventor
Helen Jane Bryant
Mark Stuart Chambers
Philip Jones
Angus Murray Macleod
Robert James Maxey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2195401A publication Critical patent/AU2195401A/en
Application granted granted Critical
Publication of AU780554B2 publication Critical patent/AU780554B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU21954/01A 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition Ceased AU780554B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9929569.3A GB9929569D0 (en) 1999-12-14 1999-12-14 Therapeutic agents
GB9929569 1999-12-14
PCT/GB2000/004752 WO2001044250A1 (en) 1999-12-14 2000-12-11 SUBSTITUTED 1,2,3-TRIAZOLO[1,5-a]QUINAZOLINES FOR ENHANCING COGNITION

Publications (2)

Publication Number Publication Date
AU2195401A AU2195401A (en) 2001-06-25
AU780554B2 true AU780554B2 (en) 2005-03-24

Family

ID=10866311

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21954/01A Ceased AU780554B2 (en) 1999-12-14 2000-12-11 Substituted 1,2,3-triazolo(1,5-a)quinazolines for enhancing cognition

Country Status (7)

Country Link
US (1) US7144887B2 (enExample)
EP (1) EP1242423A1 (enExample)
JP (1) JP2003516994A (enExample)
AU (1) AU780554B2 (enExample)
CA (1) CA2392955A1 (enExample)
GB (1) GB9929569D0 (enExample)
WO (1) WO2001044250A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0108475D0 (en) * 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
EP2321285A1 (en) 2008-07-28 2011-05-18 F. Hoffmann-La Roche AG Diazepan and piperazine derivatives modulators of chemokine receptors
AU2011328993B2 (en) 2010-11-15 2017-03-02 Agenebio, Inc. Pyridazine derivatives, compositions and methods for treating cognitive impairment
MX2013005443A (es) * 2010-11-15 2013-10-07 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN104363908B (zh) * 2012-05-30 2017-12-22 霍夫曼-拉罗奇有限公司 吡咯烷基杂环类
EP4032889B1 (en) 2013-12-20 2026-05-06 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EP3310785B1 (en) 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN107344937A (zh) * 2016-05-06 2017-11-14 如东赛默罗生物科技有限公司 三唑并[1,5-a]喹唑啉类衍生物、其制备方法、药物组合物和用途
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
AU2019288382B2 (en) 2018-06-19 2024-07-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21834A (en) 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US5306819A (en) 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
DE19617862A1 (de) * 1996-04-23 1997-10-30 Schering Ag Phthalazinderivate, deren Herstellung und Verwendung als Arzneimittel
EP0915875B1 (en) 1996-07-25 2003-04-09 MERCK SHARP & DOHME LTD. Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
WO1998050385A1 (en) * 1997-05-08 1998-11-12 Merck Sharp & Dohme Limited SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS
GB9813006D0 (en) * 1998-06-16 1998-08-12 Merck Sharp & Dohme Therapeutic agents
GB9929687D0 (en) * 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
GB9929569D0 (en) 2000-02-09
AU2195401A (en) 2001-06-25
US7144887B2 (en) 2006-12-05
US20030125333A1 (en) 2003-07-03
EP1242423A1 (en) 2002-09-25
JP2003516994A (ja) 2003-05-20
WO2001044250A1 (en) 2001-06-21
CA2392955A1 (en) 2001-06-21

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