AU777225B2 - G-motif oligonucleotides and uses thereof - Google Patents

G-motif oligonucleotides and uses thereof Download PDF

Info

Publication number
AU777225B2
AU777225B2 AU58603/99A AU5860399A AU777225B2 AU 777225 B2 AU777225 B2 AU 777225B2 AU 58603/99 A AU58603/99 A AU 58603/99A AU 5860399 A AU5860399 A AU 5860399A AU 777225 B2 AU777225 B2 AU 777225B2
Authority
AU
Australia
Prior art keywords
oligonucleotide
composition
cells
present
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU58603/99A
Other languages
English (en)
Other versions
AU5860399A (en
Inventor
Klaus Heeg
Grayson B. Lipford
Hermann Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coley Pharmaceutical GmbH
Original Assignee
Coley Pharmaceutical GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharmaceutical GmbH filed Critical Coley Pharmaceutical GmbH
Publication of AU5860399A publication Critical patent/AU5860399A/en
Priority to AU2004203808A priority Critical patent/AU2004203808A1/en
Application granted granted Critical
Publication of AU777225B2 publication Critical patent/AU777225B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU58603/99A 1998-09-03 1999-09-03 G-motif oligonucleotides and uses thereof Ceased AU777225B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2004203808A AU2004203808A1 (en) 1998-09-03 2004-08-10 G-Motif Oligonucleotides and Uses Thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98116652 1998-09-03
EP98116652 1998-09-03
PCT/EP1999/006502 WO2000014217A2 (fr) 1998-09-03 1999-09-03 Oligonucleotides a motif g et leurs utilisations

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2004203808A Division AU2004203808A1 (en) 1998-09-03 2004-08-10 G-Motif Oligonucleotides and Uses Thereof

Publications (2)

Publication Number Publication Date
AU5860399A AU5860399A (en) 2000-03-27
AU777225B2 true AU777225B2 (en) 2004-10-07

Family

ID=8232574

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58603/99A Ceased AU777225B2 (en) 1998-09-03 1999-09-03 G-motif oligonucleotides and uses thereof

Country Status (4)

Country Link
EP (1) EP1108017A2 (fr)
AU (1) AU777225B2 (fr)
CA (1) CA2341338A1 (fr)
WO (1) WO2000014217A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
EP0855184A1 (fr) 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
PT1077722E (pt) 1998-05-22 2006-12-29 Coley Pharm Group Inc Produtos e composições para utilização na indução da imunidade mucosal
EP2204186B1 (fr) 1999-02-17 2016-04-06 CSL Limited Complexes immunogènes et méthodes y relatives
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
DK1366077T3 (da) 2000-09-15 2011-09-12 Coley Pharm Gmbh Fremgangsmåde til screening i store mængder af CpG-baserede immunoagonister/-antagonister
JP4383534B2 (ja) 2001-08-17 2009-12-16 コーリー ファーマシューティカル ゲーエムベーハー 改善した活性を有する組み合わせモチーフ免疫刺激オリゴヌクレオチド
ATE447967T1 (de) 2001-09-14 2009-11-15 Cytos Biotechnology Ag Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung
NZ573064A (en) 2002-04-04 2011-02-25 Coley Pharm Gmbh Immunostimulatory G,U-containing oligoribonucleotides
CN101160399A (zh) * 2002-04-22 2008-04-09 拜奥尼茨生命科学公司 寡核苷酸组合物及其在调节免疫应答中的应用
CA2388049A1 (fr) 2002-05-30 2003-11-30 Immunotech S.A. Oligonucleotides immunostimulateurs et utilisations connexes
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
ZA200503511B (en) 2002-10-29 2006-10-25 Coley Pharmaceutical Group Ltd Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
CA2502015A1 (fr) 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. Acides nucleiques 5'cpg et leurs methodes d'utilisation
NZ542323A (en) 2003-03-26 2008-07-31 Cytos Biotechnology Ag Melan-A peptide analogue-virus-like-particle conjugates
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
GEP20094767B (en) 2003-10-30 2009-09-10 Coley Pharm Group Inc C-class oligonucleotide analogs with enhanced immunostimulatory potency
NZ553244A (en) 2004-07-18 2009-10-30 Csl Ltd Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
PT1957647E (pt) 2005-11-25 2015-06-01 Zoetis Belgium S A Oligorribonucleótidos imunoestimulantes
EP1973608A1 (fr) 2005-12-14 2008-10-01 Cytos Biotechnology AG Particules emballees avec des acides nucleiques immunostimulateurs pour le traitement de l hypersensibilite
DK2032592T3 (da) 2006-06-12 2013-09-02 Cytos Biotechnology Ag Fremgangsmåder til pakning af oligonukleotider til virus-lignende partikler af rna-bakteriofager
KR101251707B1 (ko) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체
US7879812B2 (en) 2007-08-06 2011-02-01 University Of Iowa Research Foundation Immunomodulatory oligonucleotides and methods of use therefor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024380A1 (fr) * 1995-02-09 1996-08-15 Icn Pharmaceuticals, Inc. Methodes et compositions de regulation de l'expression de cd28
WO1998029430A1 (fr) * 1996-12-27 1998-07-09 Icn, Pharmaceuticals, Inc. Oligo-aptameres riches en proteine g et procede de modulation d'une reponse immunitaire
WO1998032462A1 (fr) * 1997-01-23 1998-07-30 Hermann Wagner Compositions pharmaceutique comportant un polynucleotide et eventuellement un antigene des plus utile en matiere de vaccination

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024380A1 (fr) * 1995-02-09 1996-08-15 Icn Pharmaceuticals, Inc. Methodes et compositions de regulation de l'expression de cd28
WO1998029430A1 (fr) * 1996-12-27 1998-07-09 Icn, Pharmaceuticals, Inc. Oligo-aptameres riches en proteine g et procede de modulation d'une reponse immunitaire
WO1998032462A1 (fr) * 1997-01-23 1998-07-30 Hermann Wagner Compositions pharmaceutique comportant un polynucleotide et eventuellement un antigene des plus utile en matiere de vaccination

Also Published As

Publication number Publication date
WO2000014217A2 (fr) 2000-03-16
CA2341338A1 (fr) 2000-03-16
AU5860399A (en) 2000-03-27
EP1108017A2 (fr) 2001-06-20
WO2000014217A3 (fr) 2000-07-13

Similar Documents

Publication Publication Date Title
AU777225B2 (en) G-motif oligonucleotides and uses thereof
AU724325B2 (en) Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination
CA2340174C (fr) Compositions de cpg et d'adjuvants a base de saponine et leurs procedes d'utilisation
EP2901856B1 (fr) Multimères d'oligonucléotides immunostimulateurs
US7148191B2 (en) Antigenic composition
CA2483012C (fr) Compositions d'oligonucleotides et leur utilisation pour la modulation de reponses immunitaires
Van Uden et al. Immunostimulatory DNA and applications to allergic disease
PT1511845E (pt) Oligonucleótidos imuno-estimuladores e suas utilizações
RU2448729C2 (ru) Композиции, вызывающие специфический ответ цитотоксических т-лимфоцитов, включающие лимфо-аблативное соединение и молекулу, содержащую антигенные последовательности и нацеленную на специализированные антиген-презентирующие клетки
AU2001275294A1 (en) Immunostimulatory RNA/DNA hybrid molecules
AU2003232553A1 (en) Immunomodulation using altered dendritic cells
Wang et al. Synthetic oligodeoxynucleotides containing deoxycytidyl-deoxyguanosine dinucleotides (CpG ODNs) and modified analogs as novel anticancer therapeutics
KR20180053664A (ko) Hiv 치료 방법
Decker et al. Effect of immunostimulatory CpG-oligonucleotides in chronic lymphocytic leukemia B cells
AU2003246396B2 (en) A method for generating antigen-presenting cells
JP2005512518A (ja) 熱ショックタンパク質の使用
Van Uden et al. Introduction to immunostimulatory DNA sequences
Chu et al. CpG DNA switches on Th1 immunity and modulates antigen-presenting cell function
AU2004203808A1 (en) G-Motif Oligonucleotides and Uses Thereof
KR20200120329A (ko) 항원 전달용 조성물
Heeg CpG DNA co-stimulates antigen-reactive T cells
Li Impact of immuno-adjuvants on anti-lymphoma vaccine efficacy