AU773618B2 - Water-insoluble drug delivery system - Google Patents
Water-insoluble drug delivery system Download PDFInfo
- Publication number
- AU773618B2 AU773618B2 AU31278/00A AU3127800A AU773618B2 AU 773618 B2 AU773618 B2 AU 773618B2 AU 31278/00 A AU31278/00 A AU 31278/00A AU 3127800 A AU3127800 A AU 3127800A AU 773618 B2 AU773618 B2 AU 773618B2
- Authority
- AU
- Australia
- Prior art keywords
- delivery system
- water
- drug delivery
- drug
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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Landscapes
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| US11342398P | 1998-12-22 | 1998-12-22 | |
| US60/113423 | 1998-12-22 | ||
| PCT/US1999/030631 WO2000037050A1 (en) | 1998-12-22 | 1999-12-22 | Water-insoluble drug delivery system |
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| AU3127800A AU3127800A (en) | 2000-07-12 |
| AU773618B2 true AU773618B2 (en) | 2004-05-27 |
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| AU31278/00A Ceased AU773618B2 (en) | 1998-12-22 | 1999-12-22 | Water-insoluble drug delivery system |
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| JP (1) | JP2002532535A (enExample) |
| AT (1) | ATE289801T1 (enExample) |
| AU (1) | AU773618B2 (enExample) |
| CA (1) | CA2356959C (enExample) |
| DE (1) | DE69924004T2 (enExample) |
| WO (1) | WO2000037050A1 (enExample) |
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| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US7037528B2 (en) | 2000-12-22 | 2006-05-02 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| CN1558755A (zh) | 2001-09-26 | 2004-12-29 | ���ع��ʹ�˾ | 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| KR101169478B1 (ko) | 2003-04-30 | 2012-07-27 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 용액 의약조성물 |
| US20050020534A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites |
| US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
| CA2581126A1 (en) * | 2004-09-24 | 2006-04-06 | Rfe Pharma Llc | Carboxy-amido-triazoles for the localized treatment of ocular diseases |
| US20160106717A1 (en) | 2004-09-24 | 2016-04-21 | Gen Pharma Holdings LLC | Cai-based systems and methods for the localized treatment of uveitis |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| AU2013204198B2 (en) * | 2005-02-18 | 2016-04-21 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA2602257A1 (en) | 2005-03-30 | 2006-10-05 | Conforma Therapeutics Corporation | Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors |
| WO2008055386A1 (fr) * | 2006-11-10 | 2008-05-15 | Shenzhen Shengeryimei Biotech Co., Ltd. | Composition pharmaceutique hydrosoluble pour injection de 17-allyl amino-17-déméthoxy geldanamycine (17-aag) |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| GB2451811A (en) | 2007-08-09 | 2009-02-18 | Ems Sa | Delivery composition for solubilising water-insoluble pharmaceutical active ingredients |
| EP2525819B1 (en) * | 2010-01-19 | 2018-06-06 | Robert Coifman | Immunotherapy compositions and methods of treatment |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2609631A1 (fr) * | 1987-01-15 | 1988-07-22 | Sanofi Sa | Compositions liquides stables a base de bithionol |
| EP0648494A1 (en) * | 1993-09-30 | 1995-04-19 | American Home Products Corporation | Rapamycin formulations for oral administration |
| EP0720853A1 (en) * | 1995-01-05 | 1996-07-10 | Ciba-Geigy Ag | Topical administrable zinc phtalocyanine compositions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55111469A (en) * | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
| AU638245B2 (en) * | 1989-03-31 | 1993-06-24 | Regents Of The University Of California, The | Preparation of liposome and lipid complex compositions |
| DE4125255A1 (de) * | 1991-07-31 | 1993-02-04 | Knoll Ag | Prostaglandin e (pfeil abwaerts)1(pfeil abwaerts)-formulierung |
| WO1997003668A1 (en) * | 1995-07-21 | 1997-02-06 | Constantia Gruppe | Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles |
| US5877205A (en) * | 1996-06-28 | 1999-03-02 | Board Of Regents, The University Of Texas System | Parenteral paclitaxel in a stable non-toxic formulation |
| US6110492A (en) * | 1997-05-28 | 2000-08-29 | Jenner Biotherapies, Inc. | Immunogenic compositions |
| AU4650899A (en) * | 1998-07-10 | 2000-02-01 | Welfide Corporation | Kit of drug-containing preparation to be prepared before using and resolvent therefor |
-
1999
- 1999-12-22 JP JP2000589161A patent/JP2002532535A/ja active Pending
- 1999-12-22 AU AU31278/00A patent/AU773618B2/en not_active Ceased
- 1999-12-22 EP EP99965336A patent/EP1140017B9/en not_active Expired - Lifetime
- 1999-12-22 DE DE69924004T patent/DE69924004T2/de not_active Expired - Lifetime
- 1999-12-22 CA CA002356959A patent/CA2356959C/en not_active Expired - Fee Related
- 1999-12-22 WO PCT/US1999/030631 patent/WO2000037050A1/en not_active Ceased
- 1999-12-22 AT AT99965336T patent/ATE289801T1/de not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2609631A1 (fr) * | 1987-01-15 | 1988-07-22 | Sanofi Sa | Compositions liquides stables a base de bithionol |
| EP0648494A1 (en) * | 1993-09-30 | 1995-04-19 | American Home Products Corporation | Rapamycin formulations for oral administration |
| EP0720853A1 (en) * | 1995-01-05 | 1996-07-10 | Ciba-Geigy Ag | Topical administrable zinc phtalocyanine compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1140017B9 (en) | 2005-05-04 |
| CA2356959C (en) | 2009-03-31 |
| CA2356959A1 (en) | 2000-06-29 |
| EP1140017B1 (en) | 2005-03-02 |
| EP1140017A1 (en) | 2001-10-10 |
| DE69924004D1 (de) | 2005-04-07 |
| AU3127800A (en) | 2000-07-12 |
| DE69924004T2 (de) | 2006-02-09 |
| WO2000037050A1 (en) | 2000-06-29 |
| ATE289801T1 (de) | 2005-03-15 |
| JP2002532535A (ja) | 2002-10-02 |
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| FGA | Letters patent sealed or granted (standard patent) |