AU764660B2 - Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane - Google Patents
Use of the cell's own transport system for transferring nucleic acids across the nuclear membraneInfo
- Publication number
- AU764660B2 AU764660B2 AU25337/00A AU2533700A AU764660B2 AU 764660 B2 AU764660 B2 AU 764660B2 AU 25337/00 A AU25337/00 A AU 25337/00A AU 2533700 A AU2533700 A AU 2533700A AU 764660 B2 AU764660 B2 AU 764660B2
- Authority
- AU
- Australia
- Prior art keywords
- dna
- nls
- nuclear
- transport
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| DE19900513 | 1999-01-08 | ||
| DE19900513 | 1999-01-08 | ||
| DE19933939 | 1999-07-20 | ||
| DE19933939A DE19933939A1 (de) | 1999-01-08 | 1999-07-20 | Ausnutzung zelleigener Transportsysteme zum Transfer von Nukleinsäuren durch die Kernhülle |
| PCT/DE2000/000061 WO2000040742A1 (de) | 1999-01-08 | 2000-01-03 | Ausnutzung zelleigener transportsysteme zum transfer von nukleinsäuren durch die kernhülle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2533700A AU2533700A (en) | 2000-07-24 |
| AU764660B2 true AU764660B2 (en) | 2003-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU25337/00A Ceased AU764660B2 (en) | 1999-01-08 | 2000-01-03 | Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane |
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| Country | Link |
|---|---|
| US (1) | US6521456B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1141364A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP3997056B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1262668C (cg-RX-API-DMAC7.html) |
| AU (1) | AU764660B2 (cg-RX-API-DMAC7.html) |
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| IL (1) | IL143983A0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000040742A1 (cg-RX-API-DMAC7.html) |
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| US20030069173A1 (en) * | 1998-03-16 | 2003-04-10 | Life Technologies, Inc. | Peptide-enhanced transfections |
| CA2358040C (en) * | 1999-01-08 | 2008-06-10 | Amaxa Gmbh | Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane |
| AU785007B2 (en) * | 1999-11-24 | 2006-08-24 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| US20040063906A1 (en) * | 2000-11-24 | 2004-04-01 | Nielsen Peter E. | Pna analogues |
| WO2002053574A2 (en) * | 2001-01-05 | 2002-07-11 | Pantheco A/S | Modified pna molecules |
| DE10290072D2 (de) | 2001-01-10 | 2003-12-18 | Amaxa Gmbh | Modulare Transfektionssysteme |
| WO2003092735A2 (en) * | 2002-05-01 | 2003-11-13 | Pantheco A/S | Peptide nucleic acid conjugates with beta-amino acid polymers or reptoids |
| AU2003219576A1 (en) * | 2003-04-03 | 2004-10-25 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US8969543B2 (en) * | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| US20070149496A1 (en) * | 2003-10-31 | 2007-06-28 | Jack Tuszynski | Water-soluble compound |
| CN101287835A (zh) * | 2005-08-17 | 2008-10-15 | 株式会社百奥尼 | 用于siRNA细胞内输送的siRNA-亲水性聚合物结合物及其方法 |
| EP1900820A1 (en) * | 2006-09-13 | 2008-03-19 | Amaxa AG | Nuclear transport agent and method for producing said agent |
| EP3794132A1 (en) | 2018-05-18 | 2021-03-24 | F. Hoffmann-La Roche AG | Targeted intracellular delivery of large nucleic acids |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| ATE260679T1 (de) * | 1992-04-03 | 2004-03-15 | Univ California | Selbstorganisierendes system zur verabreichung von polynukleotiden enthaltend ein amphiphatisches peptid |
| US5574142A (en) * | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| CA2183667A1 (en) * | 1994-02-22 | 1995-08-24 | Wayne A. Marasco | Nucleic acid delivery system, method of synthesis and uses thereof |
| CA2187818A1 (en) * | 1994-04-15 | 1995-10-26 | Robert W. Overell | Gene delivery fusion proteins |
| US5670347A (en) * | 1994-05-11 | 1997-09-23 | Amba Biosciences Llc | Peptide-mediated gene transfer |
| US5736392A (en) | 1995-06-07 | 1998-04-07 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| DE19541679A1 (de) | 1995-11-08 | 1997-05-15 | Gerhard Dr Friedrich | Nicht virale Gentransfersysteme mit NLS (nuclear localization sequences) und/oder magnetisierbaren Mikropartikeln und das damit verbundene Herstellungsverfahren |
| AUPN741696A0 (en) * | 1996-01-05 | 1996-01-25 | Commonwealth Scientific And Industrial Research Organisation | Delivery of nucleic acids ii |
| CA2275892A1 (en) * | 1996-12-23 | 1998-07-02 | Gene-Cell, Inc. | Nucleic acid constructs and uses thereof for direct nucleic acid incorporation into cells |
| AU7127598A (en) * | 1997-04-18 | 1998-11-13 | Millennium Pharmaceuticals, Inc. | Novel molecules of the fthma-070-related protein family and the t85-related pro tein family and uses thereof |
| CA2358040C (en) * | 1999-01-08 | 2008-06-10 | Amaxa Gmbh | Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane |
| US6312956B1 (en) * | 1999-10-01 | 2001-11-06 | Vanderbilt University | Nuclear targeted peptide nucleic acid oligomer |
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2000
- 2000-01-03 CA CA002358040A patent/CA2358040C/en not_active Expired - Fee Related
- 2000-01-03 JP JP2000592436A patent/JP3997056B2/ja not_active Expired - Fee Related
- 2000-01-03 EP EP00903497A patent/EP1141364A1/de not_active Withdrawn
- 2000-01-03 AU AU25337/00A patent/AU764660B2/en not_active Ceased
- 2000-01-03 US US09/869,875 patent/US6521456B1/en not_active Expired - Fee Related
- 2000-01-03 CN CNB008034478A patent/CN1262668C/zh not_active Expired - Fee Related
- 2000-01-03 IL IL14398300A patent/IL143983A0/xx unknown
- 2000-01-03 WO PCT/DE2000/000061 patent/WO2000040742A1/de not_active Ceased
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2006
- 2006-07-26 JP JP2006203335A patent/JP2006345867A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US6521456B1 (en) | 2003-02-18 |
| IL143983A0 (en) | 2002-04-21 |
| WO2000040742A1 (de) | 2000-07-13 |
| JP3997056B2 (ja) | 2007-10-24 |
| CA2358040A1 (en) | 2000-07-13 |
| JP2002534437A (ja) | 2002-10-15 |
| AU2533700A (en) | 2000-07-24 |
| CN1262668C (zh) | 2006-07-05 |
| EP1141364A1 (de) | 2001-10-10 |
| CN1339068A (zh) | 2002-03-06 |
| JP2006345867A (ja) | 2006-12-28 |
| CA2358040C (en) | 2008-06-10 |
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