AU750820B2 - Nucleic acid ligands of tissue target - Google Patents
Nucleic acid ligands of tissue target Download PDFInfo
- Publication number
- AU750820B2 AU750820B2 AU16004/99A AU1600499A AU750820B2 AU 750820 B2 AU750820 B2 AU 750820B2 AU 16004/99 A AU16004/99 A AU 16004/99A AU 1600499 A AU1600499 A AU 1600499A AU 750820 B2 AU750820 B2 AU 750820B2
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- Prior art keywords
- seq
- nucleic acid
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- feature
- selex
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
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- A—HUMAN NECESSITIES
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase
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- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
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- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9726—Tissue plasminogen activator
-
- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
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- G—PHYSICS
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
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- Physics & Mathematics (AREA)
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- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
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- Food Science & Technology (AREA)
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- Endocrinology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/976,413 US6127119A (en) | 1990-06-11 | 1997-11-21 | Nucleic acid ligands of tissue target |
US08/976413 | 1997-11-21 | ||
PCT/US1998/025006 WO1999027138A1 (en) | 1997-11-21 | 1998-11-19 | Nucleic acid ligands of tissue target |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1600499A AU1600499A (en) | 1999-06-15 |
AU750820B2 true AU750820B2 (en) | 2002-07-25 |
Family
ID=25524076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU16004/99A Expired AU750820B2 (en) | 1997-11-21 | 1998-11-19 | Nucleic acid ligands of tissue target |
Country Status (6)
Country | Link |
---|---|
US (1) | US6127119A (ja) |
EP (1) | EP1032708A4 (ja) |
JP (1) | JP2001524320A (ja) |
AU (1) | AU750820B2 (ja) |
CA (1) | CA2311164A1 (ja) |
WO (1) | WO1999027138A1 (ja) |
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WO2006135527A2 (en) | 2005-06-10 | 2006-12-21 | Saint Louis University | Methods for the selection of aptamers |
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US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
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US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
AU2020381646A1 (en) * | 2019-11-14 | 2022-04-07 | i-ZUM-X Pty Ltd | Method of detection of fibrin clots |
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Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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DE3590766T (ja) * | 1985-03-30 | 1987-04-23 | ||
WO1989006694A1 (en) * | 1988-01-15 | 1989-07-27 | Trustees Of The University Of Pennsylvania | Process for selection of proteinaceous substances which mimic growth-inducing molecules |
US5750342A (en) * | 1990-06-11 | 1998-05-12 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
US5688935A (en) * | 1990-06-11 | 1997-11-18 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
CA2104698A1 (en) * | 1991-02-21 | 1992-08-22 | John J. Toole | Aptamers specific for biomolecules and methods of making |
WO1994006934A1 (en) * | 1992-09-11 | 1994-03-31 | Duke University | Method for deriving epitopes |
US5614503A (en) * | 1993-11-12 | 1997-03-25 | Aronex Pharmaceuticals, Inc. | Amphipathic nucleic acid transporter |
DE69633386T2 (de) * | 1995-05-03 | 2005-09-22 | Gilead Sciences, Inc., Foster City | Nukleinsäureliganden für gewebeziele |
-
1997
- 1997-11-21 US US08/976,413 patent/US6127119A/en not_active Expired - Fee Related
-
1998
- 1998-11-19 AU AU16004/99A patent/AU750820B2/en not_active Expired
- 1998-11-19 WO PCT/US1998/025006 patent/WO1999027138A1/en not_active Application Discontinuation
- 1998-11-19 JP JP2000522279A patent/JP2001524320A/ja not_active Withdrawn
- 1998-11-19 EP EP98960403A patent/EP1032708A4/en not_active Withdrawn
- 1998-11-19 CA CA002311164A patent/CA2311164A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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EP1032708A1 (en) | 2000-09-06 |
CA2311164A1 (en) | 1999-06-03 |
EP1032708A4 (en) | 2004-09-15 |
AU1600499A (en) | 1999-06-15 |
US6127119A (en) | 2000-10-03 |
JP2001524320A (ja) | 2001-12-04 |
WO1999027138A1 (en) | 1999-06-03 |
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