AU724267B2 - Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA - Google Patents

Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA Download PDF

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AU724267B2
AU724267B2 AU28213/97A AU2821397A AU724267B2 AU 724267 B2 AU724267 B2 AU 724267B2 AU 28213/97 A AU28213/97 A AU 28213/97A AU 2821397 A AU2821397 A AU 2821397A AU 724267 B2 AU724267 B2 AU 724267B2
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rna
tumor
derived
apc
pathogen
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AU2821397A (en
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David J. Boczkowski
Eli Gilboa
Smita K. Nair
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Duke University
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Duke University
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • C12N15/625DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
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    • A61K40/19Dendritic cells
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    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
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    • A61K40/00Cellular immunotherapy
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
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    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
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    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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    • C12N2510/00Genetically modified cells
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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AU28213/97A 1996-04-30 1997-04-30 Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA Expired AU724267B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/640444 1996-04-30
US08/640,444 US5853719A (en) 1996-04-30 1996-04-30 Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
PCT/US1997/007317 WO1997041210A1 (en) 1996-04-30 1997-04-30 Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with rna

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AU2821397A AU2821397A (en) 1997-11-19
AU724267B2 true AU724267B2 (en) 2000-09-14

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US (9) US5853719A (cg-RX-API-DMAC10.html)
EP (3) EP1721987B1 (cg-RX-API-DMAC10.html)
JP (2) JP3836151B2 (cg-RX-API-DMAC10.html)
AT (1) ATE346912T1 (cg-RX-API-DMAC10.html)
AU (1) AU724267B2 (cg-RX-API-DMAC10.html)
CA (1) CA2253632C (cg-RX-API-DMAC10.html)
DE (1) DE69737023T2 (cg-RX-API-DMAC10.html)
DK (1) DK0918848T3 (cg-RX-API-DMAC10.html)
ES (1) ES2277675T3 (cg-RX-API-DMAC10.html)
PT (1) PT918848E (cg-RX-API-DMAC10.html)
WO (1) WO1997041210A1 (cg-RX-API-DMAC10.html)

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