AU723321B2 - Lipoxin compounds and their use in treating cell proliferative disorders - Google Patents

Lipoxin compounds and their use in treating cell proliferative disorders Download PDF

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Publication number
AU723321B2
AU723321B2 AU42710/97A AU4271097A AU723321B2 AU 723321 B2 AU723321 B2 AU 723321B2 AU 42710/97 A AU42710/97 A AU 42710/97A AU 4271097 A AU4271097 A AU 4271097A AU 723321 B2 AU723321 B2 AU 723321B2
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AU
Australia
Prior art keywords
cells
lxa
lipoxin
epi
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU42710/97A
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English (en)
Other versions
AU4271097A (en
Inventor
Charles N. Serhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of AU4271097A publication Critical patent/AU4271097A/en
Application granted granted Critical
Publication of AU723321B2 publication Critical patent/AU723321B2/en
Priority to AU71775/00A priority Critical patent/AU765343B2/en
Priority to AU2003271275A priority patent/AU2003271275B2/en
Priority to AU2007231814A priority patent/AU2007231814B2/en
Priority to AU2010249176A priority patent/AU2010249176A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
AU42710/97A 1996-09-13 1997-09-15 Lipoxin compounds and their use in treating cell proliferative disorders Ceased AU723321B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU71775/00A AU765343B2 (en) 1996-09-13 2000-11-23 Lipoxin compounds and their use in treating cell proliferative disorders
AU2003271275A AU2003271275B2 (en) 1996-09-13 2003-12-18 Lipoxin compounds and their use in treating cell proliferative disorders
AU2007231814A AU2007231814B2 (en) 1996-09-13 2007-11-02 Lipoxin compounds and their use in treating cell proliferative disorders
AU2010249176A AU2010249176A1 (en) 1996-09-13 2010-12-03 Lipoxin compounds and their use in treating cell proliferative disorders

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/712610 1996-09-13
US08/712,610 US6048897A (en) 1993-06-15 1996-09-13 Lipoxin compounds and their use in treating cell proliferative disorders
PCT/US1997/016342 WO1998011049A1 (en) 1996-09-13 1997-09-15 Lipoxin compounds and their use in treating cell proliferative disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU71775/00A Division AU765343B2 (en) 1996-09-13 2000-11-23 Lipoxin compounds and their use in treating cell proliferative disorders

Publications (2)

Publication Number Publication Date
AU4271097A AU4271097A (en) 1998-04-02
AU723321B2 true AU723321B2 (en) 2000-08-24

Family

ID=24862848

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42710/97A Ceased AU723321B2 (en) 1996-09-13 1997-09-15 Lipoxin compounds and their use in treating cell proliferative disorders

Country Status (11)

Country Link
US (9) US6048897A (US20020111505A1-20020815-C00034.png)
EP (3) EP0927150B1 (US20020111505A1-20020815-C00034.png)
JP (1) JP4060366B2 (US20020111505A1-20020815-C00034.png)
AT (2) ATE215924T1 (US20020111505A1-20020815-C00034.png)
AU (1) AU723321B2 (US20020111505A1-20020815-C00034.png)
CA (1) CA2265708C (US20020111505A1-20020815-C00034.png)
DE (2) DE69738918D1 (US20020111505A1-20020815-C00034.png)
DK (2) DK0927150T3 (US20020111505A1-20020815-C00034.png)
ES (2) ES2312499T3 (US20020111505A1-20020815-C00034.png)
PT (2) PT1201639E (US20020111505A1-20020815-C00034.png)
WO (1) WO1998011049A1 (US20020111505A1-20020815-C00034.png)

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EP1586550A1 (en) * 1999-03-18 2005-10-19 The Brigham And Women's Hospital, Inc. Lipoxin compounds and their use
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ATE468157T1 (de) * 2001-03-02 2010-06-15 Brigham & Womens Hospital Lipoxinanaloge als neuartige restenose-hemmer
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Also Published As

Publication number Publication date
US20010031882A1 (en) 2001-10-18
DK0927150T3 (da) 2002-07-22
AU4271097A (en) 1998-04-02
US20020111505A1 (en) 2002-08-15
US6635776B2 (en) 2003-10-21
CA2265708A1 (en) 1998-03-19
DE69711894D1 (de) 2002-05-16
US20030032827A1 (en) 2003-02-13
US6750360B2 (en) 2004-06-15
ES2312499T3 (es) 2009-03-01
US6653493B2 (en) 2003-11-25
ES2175460T3 (es) 2002-11-16
CA2265708C (en) 2003-06-10
EP1201639A2 (en) 2002-05-02
JP2001500866A (ja) 2001-01-23
US20020091279A1 (en) 2002-07-11
PT1201639E (pt) 2008-10-03
US20030134901A1 (en) 2003-07-17
EP1201639B1 (en) 2008-08-13
EP1201639A3 (en) 2003-01-02
EP0927150A1 (en) 1999-07-07
DE69711894T2 (de) 2002-11-14
US20020082435A1 (en) 2002-06-27
US6048897A (en) 2000-04-11
US6620919B2 (en) 2003-09-16
DE69738918D1 (de) 2008-09-25
WO1998011049A1 (en) 1998-03-19
ATE404522T1 (de) 2008-08-15
EP2058293A1 (en) 2009-05-13
JP4060366B2 (ja) 2008-03-12
US20020010351A1 (en) 2002-01-24
US6316648B1 (en) 2001-11-13
PT927150E (pt) 2002-08-30
ATE215924T1 (de) 2002-04-15
DK1201639T3 (da) 2008-11-24
US6569075B2 (en) 2003-05-27
EP0927150B1 (en) 2002-04-10

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