AU720755B2 - Ubiquitin conjugating enzymes having transcriptional repressor activity - Google Patents

Ubiquitin conjugating enzymes having transcriptional repressor activity Download PDF

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Publication number
AU720755B2
AU720755B2 AU76951/96A AU7695196A AU720755B2 AU 720755 B2 AU720755 B2 AU 720755B2 AU 76951/96 A AU76951/96 A AU 76951/96A AU 7695196 A AU7695196 A AU 7695196A AU 720755 B2 AU720755 B2 AU 720755B2
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AU
Australia
Prior art keywords
protein
transcriptional repressor
amino acid
activity
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU76951/96A
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English (en)
Other versions
AU7695196A (en
Inventor
Thomas F. Deuel
Thomas Shenk
Zhao-Yi Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Barnes Hospital
Princeton University
Original Assignee
Barnes Hospital
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Barnes Hospital, Princeton University filed Critical Barnes Hospital
Publication of AU7695196A publication Critical patent/AU7695196A/en
Application granted granted Critical
Publication of AU720755B2 publication Critical patent/AU720755B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AU76951/96A 1995-08-30 1996-08-30 Ubiquitin conjugating enzymes having transcriptional repressor activity Ceased AU720755B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US299595P 1995-08-30 1995-08-30
US60/002995 1995-08-30
US1804096P 1996-05-21 1996-05-21
US60/018040 1996-05-21
PCT/US1996/014013 WO1997008195A1 (fr) 1995-08-30 1996-08-30 Enzymes de conjugaison d'ubiquitine presentant une activite de repression de transcription

Publications (2)

Publication Number Publication Date
AU7695196A AU7695196A (en) 1997-03-19
AU720755B2 true AU720755B2 (en) 2000-06-08

Family

ID=26671130

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76951/96A Ceased AU720755B2 (en) 1995-08-30 1996-08-30 Ubiquitin conjugating enzymes having transcriptional repressor activity

Country Status (5)

Country Link
EP (1) EP0850250A1 (fr)
JP (1) JP2000516081A (fr)
AU (1) AU720755B2 (fr)
CA (1) CA2230689A1 (fr)
WO (1) WO1997008195A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9664598A (en) * 1997-09-23 1999-04-12 Incyte Pharmaceuticals, Inc. Human ubiquitin-conjugating enzymes
CA2316036A1 (fr) 1999-08-27 2001-02-27 Keqiang Wu Regulation de l'expression genetique chez des vegetaux
CN103091498B (zh) * 2013-01-08 2014-12-31 中国科学院遗传与发育生物学研究所 植物体外泛素蛋白降解系统及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1866995A (en) * 1994-01-04 1995-08-01 Mitotix, Inc. Ubiquitin conjugating enzymes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1866995A (en) * 1994-01-04 1995-08-01 Mitotix, Inc. Ubiquitin conjugating enzymes

Also Published As

Publication number Publication date
WO1997008195A1 (fr) 1997-03-06
JP2000516081A (ja) 2000-12-05
EP0850250A1 (fr) 1998-07-01
CA2230689A1 (fr) 1997-03-06
AU7695196A (en) 1997-03-19

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DA3 Amendments made section 104

Free format text: 24021998

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired