AU706155B2 - 7-deoxy-6-substituted paclitaxels - Google Patents

7-deoxy-6-substituted paclitaxels Download PDF

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Publication number
AU706155B2
AU706155B2 AU34777/97A AU3477797A AU706155B2 AU 706155 B2 AU706155 B2 AU 706155B2 AU 34777/97 A AU34777/97 A AU 34777/97A AU 3477797 A AU3477797 A AU 3477797A AU 706155 B2 AU706155 B2 AU 706155B2
Authority
AU
Australia
Prior art keywords
och
alkyl
aco
nhc
och2och
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU34777/97A
Other languages
English (en)
Other versions
AU3477797A (en
Inventor
Thomas J. Altstadt
John F. Kadow
David G.I. Kingston
Xian Liang
Mark D. Wittman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Bristol Myers Squibb Co
Original Assignee
Virginia Tech Intellectual Properties Inc
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc, Bristol Myers Squibb Co filed Critical Virginia Tech Intellectual Properties Inc
Publication of AU3477797A publication Critical patent/AU3477797A/en
Assigned to BRISTOL-MYERS SQUIBB COMPANY, VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. reassignment BRISTOL-MYERS SQUIBB COMPANY Amend patent request/document other than specification (104) Assignors: BRISTOL-MYERS SQUIBB COMPANY
Application granted granted Critical
Publication of AU706155B2 publication Critical patent/AU706155B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU34777/97A 1996-06-06 1997-06-05 7-deoxy-6-substituted paclitaxels Ceased AU706155B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1949396P 1996-06-06 1996-06-06
US60/019493 1996-06-06
US60/042599 1997-04-02
US4259997P 1997-04-21 1997-04-21
PCT/US1997/009776 WO1997046232A1 (en) 1996-06-06 1997-06-05 7-deoxy-6-substituted paclitaxels

Publications (2)

Publication Number Publication Date
AU3477797A AU3477797A (en) 1998-01-05
AU706155B2 true AU706155B2 (en) 1999-06-10

Family

ID=26692272

Family Applications (1)

Application Number Title Priority Date Filing Date
AU34777/97A Ceased AU706155B2 (en) 1996-06-06 1997-06-05 7-deoxy-6-substituted paclitaxels

Country Status (6)

Country Link
US (1) US5773461A (cg-RX-API-DMAC7.html)
EP (1) EP0949918A1 (cg-RX-API-DMAC7.html)
JP (1) JP2000511905A (cg-RX-API-DMAC7.html)
AU (1) AU706155B2 (cg-RX-API-DMAC7.html)
CA (1) CA2257261A1 (cg-RX-API-DMAC7.html)
WO (1) WO1997046232A1 (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
HUP0103401A3 (en) 1998-08-18 2005-11-28 Bristol Myers Squibb Co Process for the preparation of c-4 deacetyltaxanes
US20050192360A1 (en) * 1999-04-14 2005-09-01 Li Chiang J. Method of treatment of pancreatic cancer
US20050222246A1 (en) * 1999-04-14 2005-10-06 Li Chiang J Beta-lapachone is a broad spectrum anti-cancer agent
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
EP1318794A2 (en) * 2000-09-22 2003-06-18 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US7070797B2 (en) * 2000-11-07 2006-07-04 Dana Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers
US20050197405A1 (en) * 2000-11-07 2005-09-08 Li Chiang J. Treatment of hematologic tumors and cancers with beta-lapachone, a broad spectrum anti-cancer agent
US6816571B2 (en) * 2002-02-06 2004-11-09 L-3 Communications Security And Detection Systems Corporation Delaware Method and apparatus for transmitting information about a target object between a prescanner and a CT scanner
ATE431343T1 (de) * 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US20050187288A1 (en) * 2004-02-20 2005-08-25 Chiang Li Beta-lapachone and methods of treating cancer
US20050192247A1 (en) * 2004-02-23 2005-09-01 Li Chiang J. Method of treating cancers
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
WO2014164682A1 (en) 2013-03-12 2014-10-09 Abbvie Inc. Azaadamantane formate ester and process preparing azaadamantane derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
BR9405798A (pt) * 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
EP0739210B1 (en) * 1993-12-29 2002-07-24 Matrix Pharmaceutical, Inc. Compositions for local delivery of cytostatic agents
GB2296239B (en) * 1994-12-21 1998-08-26 Erba Carlo Spa Taxane derivatives

Also Published As

Publication number Publication date
EP0949918A1 (en) 1999-10-20
JP2000511905A (ja) 2000-09-12
AU3477797A (en) 1998-01-05
CA2257261A1 (en) 1997-12-11
WO1997046232A1 (en) 1997-12-11
EP0949918A4 (cg-RX-API-DMAC7.html) 1999-11-03
US5773461A (en) 1998-06-30

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired