AU702309B2 - Cationic oligonucleotides, and related methods of synthesis and use - Google Patents

Cationic oligonucleotides, and related methods of synthesis and use Download PDF

Info

Publication number
AU702309B2
AU702309B2 AU68971/96A AU6897196A AU702309B2 AU 702309 B2 AU702309 B2 AU 702309B2 AU 68971/96 A AU68971/96 A AU 68971/96A AU 6897196 A AU6897196 A AU 6897196A AU 702309 B2 AU702309 B2 AU 702309B2
Authority
AU
Australia
Prior art keywords
group
alkyl
cationic
independently selected
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68971/96A
Other languages
English (en)
Other versions
AU6897196A (en
Inventor
Tanjore Narayanaswamy Balasubramaniam
Thomas Horn
Robert L. Letsinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Northwestern University
Original Assignee
Northwestern University
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwestern University, Chiron Corp filed Critical Northwestern University
Publication of AU6897196A publication Critical patent/AU6897196A/en
Application granted granted Critical
Publication of AU702309B2 publication Critical patent/AU702309B2/en
Assigned to CHIRON DIAGNOSTICS CORPORATION, NORTHWESTERN UNIVERSITY reassignment CHIRON DIAGNOSTICS CORPORATION Alteration of Name(s) of Applicant(s) under S113 Assignors: CHIRON CORPORATION, NORTHWESTERN UNIVERSITY
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU68971/96A 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use Ceased AU702309B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US190195P 1995-08-04 1995-08-04
US60/001901 1995-08-04
US08/693831 1996-07-31
US08/693,831 US6017700A (en) 1995-08-04 1996-07-31 Cationic oligonucleotides, and related methods of synthesis and use
PCT/US1996/013056 WO1997006183A1 (en) 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use

Publications (2)

Publication Number Publication Date
AU6897196A AU6897196A (en) 1997-03-05
AU702309B2 true AU702309B2 (en) 1999-02-18

Family

ID=26669648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68971/96A Ceased AU702309B2 (en) 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use

Country Status (6)

Country Link
US (1) US6017700A (enExample)
EP (1) EP0785942A1 (enExample)
JP (2) JPH10509740A (enExample)
AU (1) AU702309B2 (enExample)
CA (1) CA2201963A1 (enExample)
WO (1) WO1997006183A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2436857A1 (en) * 2000-12-14 2002-06-20 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
CA2659103C (en) * 2006-07-12 2019-05-21 The Regents Of The University Of California Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP3348564A1 (en) * 2011-05-10 2018-07-18 Bonac Corporation Process for preparing phosphate compound bearing isotope
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
CN112007045B (zh) * 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP2885313A4 (en) 2012-08-20 2016-03-09 Univ California POLYNUCLEOTIDES WITH BIOREVERSIBLE GROUPS
US12064484B2 (en) 2013-06-28 2024-08-20 Ethris Gmbh Compositions for introducing RNA into cells
US9410172B2 (en) 2013-09-16 2016-08-09 General Electric Company Isothermal amplification using oligocation-conjugated primer sequences
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095461A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
EP3110954A1 (en) 2014-02-26 2017-01-04 Ethris GmbH Compositions for gastrointestinal administration of rna
EP3034539A1 (en) 2014-12-19 2016-06-22 Ethris GmbH Compositions for introducing nucleic acid into cells
WO2018035380A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
KR102808275B1 (ko) 2017-04-14 2025-05-20 탈락 테라퓨틱스, 인크. 면역조절 폴리뉴클레오티드, 이의 항체 접합체, 및 이의 사용 방법
WO2019006455A1 (en) 2017-06-30 2019-01-03 Solstice Biologics, Ltd. AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
BR112020021054A2 (pt) 2018-04-25 2021-02-17 Ethris Gmbh composição, processo para a preparação de uma composição, e, composições sólida e para uso
US20240156729A1 (en) 2021-02-26 2024-05-16 Ethris Gmbh Formulations for aerosol formation and aerosols for the delivery of nucleic acid
AU2022266383A1 (en) * 2021-04-28 2023-11-16 Japan Science And Technology Agency Artificial nucleic acid and nucleic acid delivering method using same
CN120129532A (zh) 2022-08-26 2025-06-10 埃泽瑞斯公司 稳定的脂质或类脂质纳米颗粒悬浮液
EP4327829A1 (en) 2022-08-26 2024-02-28 Ethris GmbH Stabilization of lipid or lipidoid nanoparticle suspensions
CN121729225A (zh) 2023-08-25 2026-03-24 埃泽瑞斯公司 具有增强药物应用的特定表面活性剂性质的稳定脂质和类脂质纳米颗粒制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586704B1 (fr) * 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
JPH07501542A (ja) * 1991-11-25 1995-02-16 ファーマジェニックス，インコーポレーテッド アミノ炭化水素ホスホン酸塩成分を有するオリゴヌクレオチド

Also Published As

Publication number Publication date
EP0785942A1 (en) 1997-07-30
AU6897196A (en) 1997-03-05
WO1997006183A1 (en) 1997-02-20
CA2201963A1 (en) 1997-02-20
US6017700A (en) 2000-01-25
JP2008013571A (ja) 2008-01-24
JPH10509740A (ja) 1998-09-22

Similar Documents

Publication Publication Date Title
US6017700A (en) Cationic oligonucleotides, and related methods of synthesis and use
KR101032008B1 (ko) 폴리뉴클레오티드 표지 시약
EP1314734A1 (en) Novel nucleoside analogs and oligonucleotide derivatives containing these analogs
JPH035495A (ja) 修飾された核酸を製造するための修飾されたホスホルアミダイト法
CN114763367B (zh) 化合物、缀合物及其用途
US5646261A (en) 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
Kois et al. Synthesis and some properties of modified oligonucleotides. II. Oligonucleotides containing 2′-deoxy-2′-fluoro-β-D-arabinofuranosyl pyrimidine nucleosides
US5807837A (en) Composition and method for the treatment or prophylaxis of viral infections using modified oligodeoxyribonucleotides
Durand et al. Oligothymidylates covalently linked to an acridine derivative and with modified phosphodiester backbone: circular dichroism studies of their interactions with complementary sequences
EP0358657B1 (en) Poly(deoxyribonucleotides), pharmaceutical compositions, use and preparation of the poly(deoxyribonucleotides)
Puri et al. Synthesis of 5′-polyarene-tethered oligo-DNAs and the thermal stability and spectroscopic properties of their duplexes and triplexes
Ramzaeva et al. Oligonucleotides Functionalized by Fluorescein and Rhodamine Dyes: Michael Addition of Methyl Acrylate to 2′‐Deoxypseudouridine
AU2006316903B2 (en) Polynucleotide labelling reagent
US20250215040A1 (en) Method and compound
CA3199239A1 (en) A compound, a conjugate and uses thereof
HK40110907A (zh) 化合物、缀合物及其用途
HK1126183B (en) Polynucleotide labelling reagent
HK1000191B (en) Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
HK1126224B (en) Polynucleotide containing a phosphate mimetic