AU702309B2 - Cationic oligonucleotides, and related methods of synthesis and use - Google Patents

Cationic oligonucleotides, and related methods of synthesis and use Download PDF

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Publication number
AU702309B2
AU702309B2 AU68971/96A AU6897196A AU702309B2 AU 702309 B2 AU702309 B2 AU 702309B2 AU 68971/96 A AU68971/96 A AU 68971/96A AU 6897196 A AU6897196 A AU 6897196A AU 702309 B2 AU702309 B2 AU 702309B2
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AU
Australia
Prior art keywords
group
alkyl
cationic
independently selected
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68971/96A
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English (en)
Other versions
AU6897196A (en
Inventor
Tanjore Narayanaswamy Balasubramaniam
Thomas Horn
Robert L. Letsinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Northwestern University
Original Assignee
Northwestern University
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Northwestern University, Chiron Corp filed Critical Northwestern University
Publication of AU6897196A publication Critical patent/AU6897196A/en
Application granted granted Critical
Publication of AU702309B2 publication Critical patent/AU702309B2/en
Assigned to CHIRON DIAGNOSTICS CORPORATION, NORTHWESTERN UNIVERSITY reassignment CHIRON DIAGNOSTICS CORPORATION Alteration of Name(s) of Applicant(s) under S113 Assignors: CHIRON CORPORATION, NORTHWESTERN UNIVERSITY
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU68971/96A 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use Ceased AU702309B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US190195P 1995-08-04 1995-08-04
US60/001901 1995-08-04
US08/693831 1996-07-31
US08/693,831 US6017700A (en) 1995-08-04 1996-07-31 Cationic oligonucleotides, and related methods of synthesis and use
PCT/US1996/013056 WO1997006183A1 (en) 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use

Publications (2)

Publication Number Publication Date
AU6897196A AU6897196A (en) 1997-03-05
AU702309B2 true AU702309B2 (en) 1999-02-18

Family

ID=26669648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68971/96A Ceased AU702309B2 (en) 1995-08-04 1996-08-01 Cationic oligonucleotides, and related methods of synthesis and use

Country Status (6)

Country Link
US (1) US6017700A (cg-RX-API-DMAC7.html)
EP (1) EP0785942A1 (cg-RX-API-DMAC7.html)
JP (2) JPH10509740A (cg-RX-API-DMAC7.html)
AU (1) AU702309B2 (cg-RX-API-DMAC7.html)
CA (1) CA2201963A1 (cg-RX-API-DMAC7.html)
WO (1) WO1997006183A1 (cg-RX-API-DMAC7.html)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2436857A1 (en) * 2000-12-14 2002-06-20 Gen-Probe Incorporated Method and kit for enhancing the association rates of polynucleotides
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
CN101506368B (zh) * 2006-07-12 2017-02-08 加利福尼亚大学董事会 通过可逆的磷酸三酯电荷中和保护基转导运输核酸
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
CA2834665C (en) * 2011-05-10 2019-08-20 Bonac Corporation Process for preparing phosphate compound bearing isotope
ES2626488T3 (es) 2011-07-19 2017-07-25 Wave Life Sciences Pte. Ltd. Procedimientos para la síntesis de ácidos nucleicos funcionalizados
ES2940887T3 (es) * 2012-07-13 2023-05-12 Wave Life Sciences Ltd Método de preparación de oligonucleótidos quirales
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
CN104781271B (zh) 2012-08-20 2018-07-06 加利福尼亚大学董事会 具有生物可逆的基团的多核苷酸
EP3013964B1 (en) 2013-06-28 2020-05-06 ethris GmbH Compositions for introducing rna into cells
US9410172B2 (en) 2013-09-16 2016-08-09 General Electric Company Isothermal amplification using oligocation-conjugated primer sequences
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
JP2017507946A (ja) 2014-02-26 2017-03-23 エスリス ゲーエムベーハーｅｔｈｒｉｓ ＧｍｂＨ Ｒｎａを胃腸内投与するための組成物
EP3034539A1 (en) 2014-12-19 2016-06-22 Ethris GmbH Compositions for introducing nucleic acid into cells
CA3033867A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
WO2018189382A1 (en) 2017-04-14 2018-10-18 Solstice Biologics, Ltd. Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
JP7256824B2 (ja) 2018-04-25 2023-04-12 エスリス ゲーエムベーハー 粒子状製剤用の凍結保護剤
JP2024507394A (ja) 2021-02-26 2024-02-19 エスリス ゲーエムベーハー エアロゾル形成用の製剤および核酸を送達するためのエアロゾル
AU2022266383A1 (en) * 2021-04-28 2023-11-16 Japan Science And Technology Agency Artificial nucleic acid and nucleic acid delivering method using same
EP4327829A1 (en) 2022-08-26 2024-02-28 Ethris GmbH Stabilization of lipid or lipidoid nanoparticle suspensions
JP2025529925A (ja) 2022-08-26 2025-09-09 エスリス ゲーエムベーハー 安定な脂質またはリピドイドナノ粒子懸濁液
WO2025045767A1 (en) 2023-08-25 2025-03-06 Ethris Gmbh Stabilized lipid and lipidoid nanoparticle formulations with specific surfactant properties for enhanced pharmaceutical applications

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586704B1 (fr) * 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
JPH07501542A (ja) * 1991-11-25 1995-02-16 ファーマジェニックス，インコーポレーテッド アミノ炭化水素ホスホン酸塩成分を有するオリゴヌクレオチド

Also Published As

Publication number Publication date
US6017700A (en) 2000-01-25
JP2008013571A (ja) 2008-01-24
EP0785942A1 (en) 1997-07-30
JPH10509740A (ja) 1998-09-22
CA2201963A1 (en) 1997-02-20
AU6897196A (en) 1997-03-05
WO1997006183A1 (en) 1997-02-20

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