AU677700B2 - Methods for inhibiting endometriosis - Google Patents
Methods for inhibiting endometriosis Download PDFInfo
- Publication number
- AU677700B2 AU677700B2 AU75787/94A AU7578794A AU677700B2 AU 677700 B2 AU677700 B2 AU 677700B2 AU 75787/94 A AU75787/94 A AU 75787/94A AU 7578794 A AU7578794 A AU 7578794A AU 677700 B2 AU677700 B2 AU 677700B2
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- Australia
- Prior art keywords
- compound
- human
- endometriosis
- formula
- treatment
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cable Transmission Systems, Equalization Of Radio And Reduction Of Echo (AREA)
Applications Claiming Priority (2)
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| US138643 | 1993-10-15 | ||
| US08/138,643 US5461065A (en) | 1993-10-15 | 1993-10-15 | Methods for inhibiting endometriosis |
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| AU7578794A AU7578794A (en) | 1995-05-04 |
| AU677700B2 true AU677700B2 (en) | 1997-05-01 |
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| JP (1) | JPH07188014A (https=) |
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| AT (1) | ATE203404T1 (https=) |
| AU (1) | AU677700B2 (https=) |
| CA (1) | CA2118092A1 (https=) |
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| ES (1) | ES2157957T3 (https=) |
| GR (1) | GR3036971T3 (https=) |
| HU (1) | HUT71235A (https=) |
| IL (1) | IL111284A (https=) |
| NO (1) | NO311242B1 (https=) |
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| PT (1) | PT652005E (https=) |
| RU (1) | RU2157203C2 (https=) |
| SG (1) | SG43319A1 (https=) |
| SI (1) | SI0652005T1 (https=) |
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| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| USRE38968E1 (en) | 1992-07-28 | 2006-02-07 | Eli Lilly And Company | Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride |
| USRE39049E1 (en) | 1992-07-28 | 2006-03-28 | Eli Lilly And Company | Methods for inhibiting bone loss |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| US5847007A (en) | 1993-05-13 | 1998-12-08 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
| US5595722A (en) | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5457116A (en) * | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods of inhibiting uterine fibrosis |
| US5478847A (en) | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| ZA956988B (en) * | 1994-08-22 | 1997-02-21 | Lilly Co Eli | Methods of inhibiting primary endometrial hyperplasia. |
| US5843964A (en) * | 1994-09-22 | 1998-12-01 | Eli Lilly And Company | Methods of inhibiting endometrial mitoses |
| US5554600A (en) * | 1995-01-20 | 1996-09-10 | Eli Lilly And Company | Methods for inhibiting endometriosis |
| DE69600709T2 (de) * | 1995-06-07 | 1999-03-18 | Eli Lilly And Co., Indianapolis, Ind. | Verbindungen mit N-Acyliertem Piperidin in der Seitenkette und Zusammensetzungen |
| KR970002795A (ko) | 1995-10-30 | 1997-01-28 | 모리 하루오 | 네비게이션(navigation)장치 |
| TW442286B (en) * | 1996-02-28 | 2001-06-23 | Pfizer | New therapeutic uses of estrogen agonists |
| IL120266A (en) * | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| CA2214072C (en) * | 1996-08-29 | 2006-11-14 | Eli Lilly And Company | Benzo [b] thiophene compounds, intermediates, processes, compositions, and methods |
| US6117911A (en) | 1997-04-11 | 2000-09-12 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US5942539A (en) * | 1997-10-03 | 1999-08-24 | Wake Forest University | Methods of treating or preventing endometriosis with phytoestrogens |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| EP1133996A4 (en) * | 1998-11-26 | 2003-04-02 | Teikoku Hormone Mfg Co Ltd | MEDICAL COMPOSITIONS FOR PERIODIC ADMINISTRATION |
| CN1250563C (zh) | 1999-05-04 | 2006-04-12 | 斯特拉坎有限公司 | 雄激素糖苷及其产生雄性征的活性 |
| WO2002056903A2 (en) * | 2001-01-17 | 2002-07-25 | Praecis Pharmaceuticals Inc. | Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| JP2004531559A (ja) * | 2001-05-22 | 2004-10-14 | イーライ・リリー・アンド・カンパニー | エストロゲン欠乏または内因性エストロゲンに対する異常な生理反応に関連する疾患を抑制するためのテトラヒドロキノリン誘導体 |
| EP1395563B1 (en) * | 2001-05-22 | 2006-03-29 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| RU2005101635A (ru) * | 2002-06-25 | 2005-08-10 | Уайт (Us) | Применение производных тиооксиндола в терапии гормонозависимых состояний |
| US20060106010A1 (en) * | 2003-05-27 | 2006-05-18 | Black Larry J | Methods for inhibiting bone loss |
| EA026675B1 (ru) | 2010-06-16 | 2017-05-31 | Эндорешерш, Инк. | Способы лечения или предотвращения эстрогензависимых заболеваний |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| WO1993007290A1 (en) * | 1991-10-07 | 1993-04-15 | Karobio Aktiebolag | An in vitro method of evaluating the effects of a substance |
| WO1993010113A1 (fr) * | 1991-11-15 | 1993-05-27 | Teikoku Hormone Mfg. Co., Ltd. | Nouveau derive de benzothiophene |
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|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
-
1993
- 1993-10-15 US US08/138,643 patent/US5461065A/en not_active Expired - Lifetime
-
1994
- 1994-10-12 UA UA94105917A patent/UA26930C2/uk unknown
- 1994-10-13 TW TW083109467A patent/TW296382B/zh active
- 1994-10-13 KR KR1019940026164A patent/KR950010893A/ko not_active Ceased
- 1994-10-13 AT AT94307528T patent/ATE203404T1/de not_active IP Right Cessation
- 1994-10-13 ZA ZA948029A patent/ZA948029B/xx unknown
- 1994-10-13 SI SI9430388T patent/SI0652005T1/xx unknown
- 1994-10-13 IL IL11128494A patent/IL111284A/xx not_active IP Right Cessation
- 1994-10-13 CA CA002118092A patent/CA2118092A1/en not_active Abandoned
- 1994-10-13 NO NO19943879A patent/NO311242B1/no not_active IP Right Cessation
- 1994-10-13 EP EP94307528A patent/EP0652005B1/en not_active Expired - Lifetime
- 1994-10-13 DE DE69427800T patent/DE69427800T2/de not_active Expired - Fee Related
- 1994-10-13 ES ES94307528T patent/ES2157957T3/es not_active Expired - Lifetime
- 1994-10-13 DK DK94307528T patent/DK0652005T3/da active
- 1994-10-13 PH PH49186A patent/PH31261A/en unknown
- 1994-10-13 AU AU75787/94A patent/AU677700B2/en not_active Ceased
- 1994-10-13 HU HU9402959A patent/HUT71235A/hu unknown
- 1994-10-13 RU RU94036772/14A patent/RU2157203C2/ru active
- 1994-10-13 NZ NZ264677A patent/NZ264677A/en unknown
- 1994-10-13 CN CN94117125A patent/CN1049335C/zh not_active Expired - Fee Related
- 1994-10-13 JP JP6247764A patent/JPH07188014A/ja active Pending
- 1994-10-13 SG SG1996008246A patent/SG43319A1/en unknown
- 1994-10-13 PT PT94307528T patent/PT652005E/pt unknown
- 1994-10-13 CZ CZ19942537A patent/CZ287246B6/cs not_active IP Right Cessation
-
1995
- 1995-04-14 US US08/422,387 patent/US5693656A/en not_active Expired - Fee Related
-
2001
- 2001-10-22 GR GR20010401841T patent/GR3036971T3/el not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| WO1993007290A1 (en) * | 1991-10-07 | 1993-04-15 | Karobio Aktiebolag | An in vitro method of evaluating the effects of a substance |
| WO1993010113A1 (fr) * | 1991-11-15 | 1993-05-27 | Teikoku Hormone Mfg. Co., Ltd. | Nouveau derive de benzothiophene |
Also Published As
| Publication number | Publication date |
|---|---|
| RU94036772A (ru) | 1996-08-27 |
| SG43319A1 (en) | 1997-10-17 |
| JPH07188014A (ja) | 1995-07-25 |
| NO943879L (no) | 1995-04-18 |
| RU2157203C2 (ru) | 2000-10-10 |
| CZ253794A3 (en) | 1995-05-17 |
| ATE203404T1 (de) | 2001-08-15 |
| EP0652005A1 (en) | 1995-05-10 |
| ES2157957T3 (es) | 2001-09-01 |
| US5693656A (en) | 1997-12-02 |
| CA2118092A1 (en) | 1995-04-16 |
| NO311242B1 (no) | 2001-11-05 |
| SI0652005T1 (en) | 2001-12-31 |
| EP0652005B1 (en) | 2001-07-25 |
| PH31261A (en) | 1998-06-18 |
| PT652005E (pt) | 2001-11-30 |
| NO943879D0 (no) | 1994-10-13 |
| HU9402959D0 (en) | 1995-02-28 |
| US5461065A (en) | 1995-10-24 |
| DE69427800T2 (de) | 2001-12-06 |
| DK0652005T3 (da) | 2001-09-24 |
| GR3036971T3 (en) | 2002-01-31 |
| HUT71235A (en) | 1995-11-28 |
| UA26930C2 (uk) | 1999-12-29 |
| IL111284A (en) | 2000-02-29 |
| CN1049335C (zh) | 2000-02-16 |
| CN1107043A (zh) | 1995-08-23 |
| DE69427800D1 (de) | 2001-08-30 |
| IL111284A0 (en) | 1994-12-29 |
| ZA948029B (en) | 1996-04-15 |
| NZ264677A (en) | 1997-07-27 |
| AU7578794A (en) | 1995-05-04 |
| CZ287246B6 (en) | 2000-10-11 |
| KR950010893A (ko) | 1995-05-15 |
| TW296382B (https=) | 1997-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |