AU676194B2 - Non-native liver generation in an animal with impaired native liver function by cell implantation - Google Patents

Non-native liver generation in an animal with impaired native liver function by cell implantation Download PDF

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Publication number
AU676194B2
AU676194B2 AU47782/93A AU4778293A AU676194B2 AU 676194 B2 AU676194 B2 AU 676194B2 AU 47782/93 A AU47782/93 A AU 47782/93A AU 4778293 A AU4778293 A AU 4778293A AU 676194 B2 AU676194 B2 AU 676194B2
Authority
AU
Australia
Prior art keywords
native
liver
cells
animal
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47782/93A
Other languages
English (en)
Other versions
AU4778293A (en
Inventor
Ralph L Brinster
Jay L Degan
Richard D Palmiter
Eric P Sandgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Cincinnati Childrens Hospital Medical Center
University of Pennsylvania Penn
Original Assignee
University of Washington
Cincinnati Childrens Hospital Medical Center
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Cincinnati Childrens Hospital Medical Center, University of Pennsylvania Penn filed Critical University of Washington
Publication of AU4778293A publication Critical patent/AU4778293A/en
Application granted granted Critical
Publication of AU676194B2 publication Critical patent/AU676194B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicines Containing Plant Substances (AREA)
AU47782/93A 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation Ceased AU676194B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91805092A 1992-07-24 1992-07-24
US918050 1992-07-24
PCT/US1993/006830 WO1994002601A1 (en) 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation

Publications (2)

Publication Number Publication Date
AU4778293A AU4778293A (en) 1994-02-14
AU676194B2 true AU676194B2 (en) 1997-03-06

Family

ID=25439709

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47782/93A Ceased AU676194B2 (en) 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation

Country Status (6)

Country Link
EP (1) EP0652949A4 (ja)
JP (1) JPH07509363A (ja)
AU (1) AU676194B2 (ja)
CA (1) CA2140785A1 (ja)
IL (1) IL106368A0 (ja)
WO (1) WO1994002601A1 (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157225T3 (es) * 1992-10-09 2001-08-16 Advanced Tissue Sciences Inc Celulas hepaticas de reserva.
US5980886A (en) * 1994-12-14 1999-11-09 University Of Washington Recombinant vectors for reconstitution of liver
US6107027A (en) * 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
WO1996039810A1 (en) * 1995-06-07 1996-12-19 Novartis Ag Human hepatocellular tissue in chimeric immunocompromised animals
US6034297A (en) * 1997-09-26 2000-03-07 Cedars-Sinai Medical Center In vivo, animal model for expression of hepatitis C virus
US6132708A (en) * 1997-10-10 2000-10-17 Oregon Health Sciences University Liver regeneration using pancreas cells
US6864402B1 (en) 1998-09-18 2005-03-08 Albert Einstein College Of Medicine Of Yeshiva University Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated livers
WO2000040083A1 (en) * 1999-01-05 2000-07-13 Surrogen, Inc. Chimeric animal with engrafted xenogeneic tissue and method for producing same
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6995299B2 (en) 1999-11-02 2006-02-07 University Of Connecticut Propagation of human hepatocytes in non-human animals
US6509514B1 (en) 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
WO2001087059A1 (fr) * 2000-05-19 2001-11-22 Japan Science And Technology Corporation Animal chimerique
US7560279B2 (en) * 2002-03-25 2009-07-14 Hiroshima Industrial Promotion Organization Method of proliferating human hepatocytes and method for obtaining human hepatocytes
WO2004006664A1 (ja) * 2002-07-16 2004-01-22 Japan Science And Technology Agency 非癌部肝臓組織が移植されたモデル動物およびその作製方法
ATE461448T1 (de) * 2004-08-20 2010-04-15 Sekisui Medical Co Ltd Verfahren zur abschätzung des metabolismus eines arzneistoffs in der menschlichen leber sowie der leberfunktion
AU2005277463A1 (en) 2004-08-20 2006-03-02 Kmt Hepatech, Inc. Malarial animal model having a chimeric human liver
WO2019059158A1 (ja) * 2017-09-19 2019-03-28 学校法人明治大学 特定の機能細胞を欠損する臓器を発達させる方法

Also Published As

Publication number Publication date
AU4778293A (en) 1994-02-14
CA2140785A1 (en) 1994-02-03
IL106368A0 (en) 1993-11-15
WO1994002601A1 (en) 1994-02-03
EP0652949A4 (en) 1996-08-21
EP0652949A1 (en) 1995-05-17
JPH07509363A (ja) 1995-10-19

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