EP0652949A4 - Non-native liver generation in an animal with impaired native liver function by cell implantation. - Google Patents

Non-native liver generation in an animal with impaired native liver function by cell implantation.

Info

Publication number
EP0652949A4
EP0652949A4 EP93918276A EP93918276A EP0652949A4 EP 0652949 A4 EP0652949 A4 EP 0652949A4 EP 93918276 A EP93918276 A EP 93918276A EP 93918276 A EP93918276 A EP 93918276A EP 0652949 A4 EP0652949 A4 EP 0652949A4
Authority
EP
European Patent Office
Prior art keywords
native liver
animal
impaired
cell implantation
generation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93918276A
Other languages
German (de)
French (fr)
Other versions
EP0652949A1 (en
Inventor
Ralph L Brinster
Richard D Palmiter
Jay L Degan
Eric P Sandgren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Cincinnati Childrens Hospital Medical Center
University of Pennsylvania Penn
Original Assignee
University of Washington
Cincinnati Childrens Hospital Medical Center
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Cincinnati Childrens Hospital Medical Center, University of Pennsylvania Penn filed Critical University of Washington
Publication of EP0652949A1 publication Critical patent/EP0652949A1/en
Publication of EP0652949A4 publication Critical patent/EP0652949A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Meat, Egg Or Seafood Products (AREA)
EP93918276A 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation. Withdrawn EP0652949A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91805092A 1992-07-24 1992-07-24
US918050 1992-07-24
PCT/US1993/006830 WO1994002601A1 (en) 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation

Publications (2)

Publication Number Publication Date
EP0652949A1 EP0652949A1 (en) 1995-05-17
EP0652949A4 true EP0652949A4 (en) 1996-08-21

Family

ID=25439709

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93918276A Withdrawn EP0652949A4 (en) 1992-07-24 1993-07-23 Non-native liver generation in an animal with impaired native liver function by cell implantation.

Country Status (6)

Country Link
EP (1) EP0652949A4 (en)
JP (1) JPH07509363A (en)
AU (1) AU676194B2 (en)
CA (1) CA2140785A1 (en)
IL (1) IL106368A0 (en)
WO (1) WO1994002601A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950703640A (en) * 1992-10-09 1995-09-20 가일 케이,나우톤. LIVER RESERVE CELLS
US5980886A (en) * 1994-12-14 1999-11-09 University Of Washington Recombinant vectors for reconstitution of liver
US6107027A (en) * 1994-12-14 2000-08-22 University Of Washington Ribozymes for treating hepatitis C
WO1996039810A1 (en) * 1995-06-07 1996-12-19 Novartis Ag Human hepatocellular tissue in chimeric immunocompromised animals
US6034297A (en) * 1997-09-26 2000-03-07 Cedars-Sinai Medical Center In vivo, animal model for expression of hepatitis C virus
US6132708A (en) * 1997-10-10 2000-10-17 Oregon Health Sciences University Liver regeneration using pancreas cells
US6864402B1 (en) 1998-09-18 2005-03-08 Albert Einstein College Of Medicine Of Yeshiva University Chronic hepatitis virus infection and clonal hepatocellular carcinoma in mouse repopulated livers
WO2000040083A1 (en) * 1999-01-05 2000-07-13 Surrogen, Inc. Chimeric animal with engrafted xenogeneic tissue and method for producing same
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6995299B2 (en) 1999-11-02 2006-02-07 University Of Connecticut Propagation of human hepatocytes in non-human animals
US6509514B1 (en) 2000-03-17 2003-01-21 Kmt Hepatech, Inc. Chimeric animal model susceptible to human hepatitis C virus infection
WO2001087059A1 (en) * 2000-05-19 2001-11-22 Japan Science And Technology Corporation Chimeric animal
WO2003080821A1 (en) * 2002-03-25 2003-10-02 Japan Science And Technology Agency Method of proliferating human hepatocytes and method of obtaining human hepatocytes
JPWO2004006664A1 (en) * 2002-07-16 2005-11-10 独立行政法人科学技術振興機構 Model animal transplanted with non-cancerous liver tissue and production method thereof
DE602005020042D1 (en) * 2004-08-20 2010-04-29 Phoenixbio Co Ltd METHOD FOR EVALUATING THE METABOLISM OF A MEDICAMENT IN THE HUMAN LIVER AND THE LIVER FUNCTION
JP2008510465A (en) 2004-08-20 2008-04-10 ケイエムティー ヒパテック インコーポレイテッド Malaria animal model with chimeric human liver
US11172657B2 (en) 2017-09-19 2021-11-16 Pormedtec Co., Ltd. Method for developing organ that lacks specific functional cell

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RONCAROLO ET AL: "SCID PATIENTS RECONSTITUTED BY FETAL LIVER STEM CELLS:POSSIBLE ROLE OF IL-10 IN TRANSPLANTATION TOLERANCE", JOURNAL OF CELLULAR BIOCHEMISTRY,SUPPLEMENT 16A,1992, 13 January 1992 (1992-01-13) - 26 January 1992 (1992-01-26), pages 214, XP002005874 *
See also references of WO9402601A1 *
SIGAL ET AL: "THE LIVER AS A STEM CELL AND LINEAGE SYSTEM", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 263, no. 2, August 1992 (1992-08-01), pages G139 - G148, XP000572600 *

Also Published As

Publication number Publication date
JPH07509363A (en) 1995-10-19
AU4778293A (en) 1994-02-14
CA2140785A1 (en) 1994-02-03
EP0652949A1 (en) 1995-05-17
AU676194B2 (en) 1997-03-06
IL106368A0 (en) 1993-11-15
WO1994002601A1 (en) 1994-02-03

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19950224

AK Designated contracting states

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Designated state(s): DE FR GB IT NL SE

RHK1 Main classification (correction)

Ipc: A01K 67/027

A4 Supplementary search report drawn up and despatched

Effective date: 19960708

AK Designated contracting states

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Designated state(s): DE FR GB IT NL SE

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Effective date: 19981208

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990420