AU675333B2 - Method for specific silencing of genes by DNA methylation - Google Patents

Method for specific silencing of genes by DNA methylation Download PDF

Info

Publication number
AU675333B2
AU675333B2 AU69653/94A AU6965394A AU675333B2 AU 675333 B2 AU675333 B2 AU 675333B2 AU 69653/94 A AU69653/94 A AU 69653/94A AU 6965394 A AU6965394 A AU 6965394A AU 675333 B2 AU675333 B2 AU 675333B2
Authority
AU
Australia
Prior art keywords
document
gene
single stranded
stranded oligonucleotide
international
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU69653/94A
Other languages
English (en)
Other versions
AU6965394A (en
Inventor
Robin Holliday
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Commonwealth Scientific and Industrial Research Organization CSIRO
Original Assignee
Commonwealth Scientific and Industrial Research Organization CSIRO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commonwealth Scientific and Industrial Research Organization CSIRO filed Critical Commonwealth Scientific and Industrial Research Organization CSIRO
Publication of AU6965394A publication Critical patent/AU6965394A/en
Application granted granted Critical
Publication of AU675333B2 publication Critical patent/AU675333B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AU69653/94A 1993-06-11 1994-06-10 Method for specific silencing of genes by DNA methylation Ceased AU675333B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPL933893 1993-06-11
AUPL9338 1993-06-11
PCT/AU1994/000314 WO1994029461A1 (fr) 1993-06-11 1994-06-10 Procede destine a rendre silencieux de façon specifique les genes par methylation de l'adn

Publications (2)

Publication Number Publication Date
AU6965394A AU6965394A (en) 1995-01-03
AU675333B2 true AU675333B2 (en) 1997-01-30

Family

ID=3776965

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69653/94A Ceased AU675333B2 (en) 1993-06-11 1994-06-10 Method for specific silencing of genes by DNA methylation

Country Status (5)

Country Link
US (1) US5840497A (fr)
EP (1) EP0707653B1 (fr)
AU (1) AU675333B2 (fr)
DE (1) DE69433978T2 (fr)
WO (1) WO1994029461A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
JP3468773B2 (ja) 1994-07-15 2003-11-17 ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション 免疫調節オリゴヌクレオチド
US5874416A (en) * 1997-11-07 1999-02-23 Sheikhnejad; Gholamreza RAS antisense inhibition
DE10032529A1 (de) * 2000-06-30 2002-02-07 Epigenomics Ag Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
US7358090B2 (en) 2000-03-24 2008-04-15 The United States Of America As Represented By The Department Of Health And Human Services Establishment of cellular manipulations which enhance oligo-mediated gene targeting
US20040006036A1 (en) * 2000-04-12 2004-01-08 Gmr, A Delaware Corporation Silencing transcription by methylation
CA2312051A1 (fr) 2000-07-13 2002-01-13 Quebepharma Inc. Regulation de l'expression genetique avec un nucleotide methyle
US20040224405A1 (en) * 2003-05-06 2004-11-11 Dharmacon Inc. siRNA induced systemic gene silencing in mammalian systems
US7524827B2 (en) * 2004-06-01 2009-04-28 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US8815599B2 (en) * 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US7807647B2 (en) * 2004-06-01 2010-10-05 Pronai Therapeutics, Inc. Methods and compositions for cancer therapy
PL1957044T3 (pl) 2005-12-01 2013-11-29 Pronai Therapeutics Inc Amfoteryczny preparat liposomowy
US9023819B2 (en) 2008-06-09 2015-05-05 National Chung Cheng University Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification
US8067163B2 (en) * 2008-06-09 2011-11-29 National Chung Cheng University Determination of the biological function of a target gene in a cell
US20100257634A1 (en) * 2009-04-03 2010-10-07 Venganza Inc. Bioassay for gene silencing constructs
WO2023122805A1 (fr) 2021-12-20 2023-06-29 Vestaron Corporation Procédé de pression de sélection par sorbitol

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4036693A (en) * 1992-04-15 1993-11-18 Commonwealth Scientific And Industrial Research Organisation Immortalisation of human cells by gene silencing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402402B1 (fr) * 1988-02-26 1995-12-27 Worcester Foundation For Biomedical Research, Inc. Inhibition du htlv-iii par des oligonucleotides exogenes
US5874416A (en) * 1997-11-07 1999-02-23 Sheikhnejad; Gholamreza RAS antisense inhibition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4036693A (en) * 1992-04-15 1993-11-18 Commonwealth Scientific And Industrial Research Organisation Immortalisation of human cells by gene silencing

Also Published As

Publication number Publication date
US5840497A (en) 1998-11-24
EP0707653A1 (fr) 1996-04-24
DE69433978D1 (de) 2004-10-07
DE69433978T2 (de) 2005-08-25
AU6965394A (en) 1995-01-03
EP0707653A4 (fr) 2002-01-30
EP0707653B1 (fr) 2004-09-01
WO1994029461A1 (fr) 1994-12-22

Similar Documents

Publication Publication Date Title
AU675333B2 (en) Method for specific silencing of genes by DNA methylation
Turker et al. Formation of methylation patterns in the mammalian genome
Prasanth et al. Eukaryotic regulatory RNAs: an answer to the ‘genome complexity’conundrum
Garel et al. Genes transcribed at diverse rates have a similar conformation in chromatin
CN102361985B (zh) 通过抑制肿瘤抑制基因的天然反义转录物治疗肿瘤抑制基因相关性疾病
Brosius The contribution of RNAs and retroposition to evolutionary novelties
Mancini-DiNardo et al. Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes
Colman Antisense strategies in cell and developmental biology
Karijolich et al. Spliceosomal snRNA modifications and their function
Srivastava et al. Mechanism and regulation of bacterial ribosomal RNA processing
Rhounim et al. Epimutation of repeated genes in Ascobolus immersus.
Ohlsson et al. Did genomic imprinting and X chromosome inactivation arise from stochastic expression?
Shaikh et al. cDNAs derived from primary and small cytoplasmic Alu (scAlu) transcripts
Borovjagin et al. U3 small nucleolar RNA is essential for cleavage at sites 1, 2 and 3 in pre-rRNA and determines which rRNA processing pathway is taken in Xenopus oocytes
Zhou et al. Programmable base editing of the sheep genome revealed no genome-wide off-target mutations
EP3214177A3 (fr) Procédés et moyens pour obtenir des phénotypes modifiés
Bachvarova Small B2 RNAs in mouse oocytes, embryos, and somatic tissues
Irelan et al. Gene silencing in filamentous fungi: RIP, MIP and quelling
JPH11514220A (ja) キメラオリゴヌクレオチド及びアンチセンス結合部位の確認におけるそれらの使用
Castro Nutrient effects on DNA and chromatin structure
US20040002104A1 (en) Constant length signatures for parallel sequencing of polynucleotides
JP2005510204A (ja) ヘアレス蛋白質発現を阻害するための核酸及びその使用方法
Holliday Dual inheritance
US20140288147A1 (en) Methods of manipulating the fate of cells
McConkey How the human genome works