AU6734798A - New derivatives of erythromycin, their preparation process and their use as medicaments - Google Patents

New derivatives of erythromycin, their preparation process and their use as medicaments

Info

Publication number
AU6734798A
AU6734798A AU67347/98A AU6734798A AU6734798A AU 6734798 A AU6734798 A AU 6734798A AU 67347/98 A AU67347/98 A AU 67347/98A AU 6734798 A AU6734798 A AU 6734798A AU 6734798 A AU6734798 A AU 6734798A
Authority
AU
Australia
Prior art keywords
erythromycin
medicaments
preparation process
nar
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU67347/98A
Other versions
AU728182B2 (en
Inventor
Constantin Agouridas
Jean-Francois Chantot
Alexis Denis
Claude Fromentin
Jean-Marie Pejac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU6734798A publication Critical patent/AU6734798A/en
Application granted granted Critical
Publication of AU728182B2 publication Critical patent/AU728182B2/en
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Abstract

The invention concerns compounds of formula (I) in which A and B form with the atoms to which they are bound a group (a): R1 = NH2, NH-alkyl, NH-alkenyl, NH-alkynyl, (CH2)nAr, NH(CH2)nAr or N=NH(CH2)nAr, Ar = aryl or heteroaryl, optionally substituted; R = H, alkyl optionally substituted, optionally interrupted by one or several heteroatoms, aryl or heteroaryl, optionally substituted, as well as the salts of compounds of formula (I). The compounds of formula (I) have interesting antibiotic properties.
AU67347/98A 1997-02-27 1998-02-26 New derivatives of erythromycin, their preparation process and their use as medicaments Expired AU728182B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9702352A FR2760017B1 (en) 1997-02-27 1997-02-27 NOVEL ERYTROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR97/02352 1997-02-27
PCT/FR1998/000378 WO1998038199A1 (en) 1997-02-27 1998-02-26 Novel erythromycin derivatives, method of preparation and application as medicines

Publications (2)

Publication Number Publication Date
AU6734798A true AU6734798A (en) 1998-09-18
AU728182B2 AU728182B2 (en) 2001-01-04

Family

ID=9504247

Family Applications (1)

Application Number Title Priority Date Filing Date
AU67347/98A Expired AU728182B2 (en) 1997-02-27 1998-02-26 New derivatives of erythromycin, their preparation process and their use as medicaments

Country Status (21)

Country Link
EP (1) EP0968222B1 (en)
JP (1) JP4531136B2 (en)
KR (1) KR100529980B1 (en)
CN (1) CN1162442C (en)
AT (1) ATE219097T1 (en)
AU (1) AU728182B2 (en)
BR (1) BR9807795A (en)
CA (1) CA2282666C (en)
DE (1) DE69805981T2 (en)
DK (1) DK0968222T3 (en)
EA (1) EA002359B1 (en)
ES (1) ES2179475T3 (en)
FR (1) FR2760017B1 (en)
HU (1) HUP0001245A3 (en)
IL (1) IL131340A0 (en)
NO (1) NO315653B1 (en)
PL (1) PL187947B1 (en)
PT (1) PT968222E (en)
TR (1) TR199902092T2 (en)
WO (1) WO1998038199A1 (en)
ZA (1) ZA981482B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2782239A1 (en) 1998-08-13 2000-02-18 Euromark Hopper for distributing animal provisions, consists of hopper with means of ejecting food and fitted with scraper to distribute products over ground
EP1115732B1 (en) 1998-09-22 2005-06-29 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
KR20020002380A (en) 1999-01-27 2002-01-09 실버스타인 아써 에이. Ketolide antibiotics
AU773678B2 (en) * 1999-04-16 2004-06-03 Kosan Biosciences, Inc. Macrolide antiinfective agents
AP2001002302A0 (en) 1999-05-24 2001-10-25 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
ID27331A (en) * 1999-09-29 2001-03-29 Pfizer Prod Inc MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE
US6673774B2 (en) 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
US6670331B2 (en) 2001-12-04 2003-12-30 Enanta Pharmaceuticals, Inc. 11-O-substituted ketolide derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2473525A1 (en) * 1980-01-11 1981-07-17 Roussel Uclaf NOVEL OXIMES DERIVED FROM ERYTHROMYCIN, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2702480B1 (en) * 1993-03-09 1995-04-28 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
FR2718450B1 (en) * 1994-04-08 1997-01-10 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
FR2719587B1 (en) * 1994-05-03 1996-07-12 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.

Also Published As

Publication number Publication date
FR2760017B1 (en) 1999-04-30
ATE219097T1 (en) 2002-06-15
CN1248261A (en) 2000-03-22
HUP0001245A1 (en) 2000-09-28
IL131340A0 (en) 2001-01-28
WO1998038199A1 (en) 1998-09-03
EP0968222A1 (en) 2000-01-05
DK0968222T3 (en) 2002-10-07
CA2282666C (en) 2008-09-02
FR2760017A1 (en) 1998-08-28
PL335375A1 (en) 2000-04-25
EP0968222B1 (en) 2002-06-12
TR199902092T2 (en) 2000-05-22
ES2179475T3 (en) 2003-01-16
PL187947B1 (en) 2004-11-30
HUP0001245A3 (en) 2003-05-28
BR9807795A (en) 2000-02-15
KR100529980B1 (en) 2005-11-22
EA002359B1 (en) 2002-04-25
DE69805981T2 (en) 2003-01-16
NO994150L (en) 1999-08-27
NO315653B1 (en) 2003-10-06
KR20000075722A (en) 2000-12-26
JP4531136B2 (en) 2010-08-25
NO994150D0 (en) 1999-08-27
JP2001513101A (en) 2001-08-28
EA199900765A1 (en) 2000-04-24
DE69805981D1 (en) 2002-07-18
ZA981482B (en) 1999-02-23
PT968222E (en) 2002-10-31
CN1162442C (en) 2004-08-18
CA2282666A1 (en) 1998-09-03
AU728182B2 (en) 2001-01-04

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL