AU672810B2 - Hydroxamic acid derivatives and their use as anti-inflammatory compounds - Google Patents
Hydroxamic acid derivatives and their use as anti-inflammatory compounds Download PDFInfo
- Publication number
- AU672810B2 AU672810B2 AU47170/93A AU4717093A AU672810B2 AU 672810 B2 AU672810 B2 AU 672810B2 AU 47170/93 A AU47170/93 A AU 47170/93A AU 4717093 A AU4717093 A AU 4717093A AU 672810 B2 AU672810 B2 AU 672810B2
- Authority
- AU
- Australia
- Prior art keywords
- methylprop
- enyl
- formula
- salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929215921A GB9215921D0 (en) | 1992-07-27 | 1992-07-27 | Anti-inflammatory compounds |
GB9215921 | 1992-07-27 | ||
PCT/GB1993/001585 WO1994002448A1 (en) | 1992-07-27 | 1993-07-27 | Hydroxamic acid derivatives and their use as anti-inflammatory compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
AU4717093A AU4717093A (en) | 1994-02-14 |
AU672810B2 true AU672810B2 (en) | 1996-10-17 |
Family
ID=10719360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU47170/93A Ceased AU672810B2 (en) | 1992-07-27 | 1993-07-27 | Hydroxamic acid derivatives and their use as anti-inflammatory compounds |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0652864A1 (uk) |
JP (1) | JPH07509462A (uk) |
AU (1) | AU672810B2 (uk) |
CA (1) | CA2141214A1 (uk) |
GB (1) | GB9215921D0 (uk) |
IL (1) | IL106472A0 (uk) |
MX (1) | MX9304503A (uk) |
TW (1) | TW246670B (uk) |
WO (1) | WO1994002448A1 (uk) |
ZA (1) | ZA935378B (uk) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2104424T3 (es) * | 1993-11-26 | 1997-10-01 | Pfizer | Compuestos de isoxazolina como agentes antiinflamatorios. |
AU1326795A (en) * | 1994-03-09 | 1995-09-25 | Pfizer Inc. | Isoxazoline compounds as 5-lipoxygenase inhibitors |
WO1996023772A1 (fr) * | 1995-02-02 | 1996-08-08 | Nikken Chemicals Co., Ltd. | Derives de n-hydroxyuree |
CA2246265A1 (en) | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors |
EP0880363B1 (en) | 1996-02-13 | 2002-09-11 | G.D. SEARLE & CO. | Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a 4 hydrolase inhibitor |
CA2246356A1 (en) | 1996-02-13 | 1997-08-21 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist |
NZ333441A (en) * | 1996-06-25 | 1999-05-28 | Cephalon Inc | Use of k-252a derivatives for the treatment of peripheral or central nerve disorders, and cytokine overproduction |
ES2189207T3 (es) * | 1997-07-31 | 2003-07-01 | Abbott Lab | Inhibidores de hidroxamatos inversos de metaloproteinasas matriciales. |
US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
WO2000044712A1 (en) * | 1999-01-27 | 2000-08-03 | Abbott Laboratories | N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases |
SE0103325D0 (sv) * | 2001-10-04 | 2001-10-04 | Astrazeneca Ab | Novel compounds |
TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0196184A2 (en) * | 1985-03-16 | 1986-10-01 | The Wellcome Foundation Limited | Aryl derivatives |
EP0299761A1 (en) * | 1987-07-15 | 1989-01-18 | The Wellcome Foundation Limited | Anti-inflammatory aryl derivatives |
WO1992010469A1 (en) * | 1990-12-11 | 1992-06-25 | Pfizer Inc. | Hydroxamic acid derivatives which inhibit lipoxygenase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0819069B2 (ja) * | 1990-07-25 | 1996-02-28 | アボツト・ラボラトリーズ | リポキシゲナーゼ阻害活性を有するアセチレン誘導体 |
-
1992
- 1992-07-27 GB GB929215921A patent/GB9215921D0/en active Pending
-
1993
- 1993-07-26 TW TW082105933A patent/TW246670B/zh active
- 1993-07-26 MX MX9304503A patent/MX9304503A/es unknown
- 1993-07-26 ZA ZA935378A patent/ZA935378B/xx unknown
- 1993-07-26 IL IL106472A patent/IL106472A0/xx unknown
- 1993-07-27 AU AU47170/93A patent/AU672810B2/en not_active Ceased
- 1993-07-27 WO PCT/GB1993/001585 patent/WO1994002448A1/en not_active Application Discontinuation
- 1993-07-27 EP EP93917925A patent/EP0652864A1/en not_active Withdrawn
- 1993-07-27 JP JP6504325A patent/JPH07509462A/ja active Pending
- 1993-07-27 CA CA002141214A patent/CA2141214A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0196184A2 (en) * | 1985-03-16 | 1986-10-01 | The Wellcome Foundation Limited | Aryl derivatives |
EP0299761A1 (en) * | 1987-07-15 | 1989-01-18 | The Wellcome Foundation Limited | Anti-inflammatory aryl derivatives |
WO1992010469A1 (en) * | 1990-12-11 | 1992-06-25 | Pfizer Inc. | Hydroxamic acid derivatives which inhibit lipoxygenase |
Also Published As
Publication number | Publication date |
---|---|
WO1994002448A1 (en) | 1994-02-03 |
JPH07509462A (ja) | 1995-10-19 |
GB9215921D0 (en) | 1992-09-09 |
EP0652864A1 (en) | 1995-05-17 |
ZA935378B (en) | 1995-01-26 |
MX9304503A (es) | 1994-04-29 |
IL106472A0 (en) | 1993-11-15 |
CA2141214A1 (en) | 1994-02-03 |
TW246670B (uk) | 1995-05-01 |
AU4717093A (en) | 1994-02-14 |
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