AU671473B2 - Aryl urea (thiourea) and cyanoguanidine derivatives - Google Patents

Aryl urea (thiourea) and cyanoguanidine derivatives Download PDF

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Publication number
AU671473B2
AU671473B2 AU46240/93A AU4624093A AU671473B2 AU 671473 B2 AU671473 B2 AU 671473B2 AU 46240/93 A AU46240/93 A AU 46240/93A AU 4624093 A AU4624093 A AU 4624093A AU 671473 B2 AU671473 B2 AU 671473B2
Authority
AU
Australia
Prior art keywords
cyano
dihydro
compound
hydroxy
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU46240/93A
Other languages
English (en)
Other versions
AU4624093A (en
Inventor
Karnail Atwal
George C. Rovnyak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of AU4624093A publication Critical patent/AU4624093A/en
Application granted granted Critical
Publication of AU671473B2 publication Critical patent/AU671473B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU46240/93A 1992-09-11 1993-09-10 Aryl urea (thiourea) and cyanoguanidine derivatives Ceased AU671473B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US944135 1986-12-22
US94413592A 1992-09-11 1992-09-11

Publications (2)

Publication Number Publication Date
AU4624093A AU4624093A (en) 1994-03-17
AU671473B2 true AU671473B2 (en) 1996-08-29

Family

ID=25480857

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46240/93A Ceased AU671473B2 (en) 1992-09-11 1993-09-10 Aryl urea (thiourea) and cyanoguanidine derivatives

Country Status (5)

Country Link
US (1) US5374643A (OSRAM)
EP (1) EP0587180A2 (OSRAM)
JP (1) JPH06293748A (OSRAM)
AU (1) AU671473B2 (OSRAM)
CA (1) CA2105959A1 (OSRAM)

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US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5747528A (en) * 1996-02-21 1998-05-05 Warner-Lambert Company Chroman derivatives as anti-oxidants
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
DE19647000A1 (de) * 1996-11-14 1998-05-20 Hoechst Ag 3-Amido-chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE69830069T3 (de) * 1997-10-17 2012-02-09 Ark Therapeutics Ltd. Verwendung von hemmern des renin-angiotensin systems zur behandlung von hypoxie oder verringertem stoffwechsel
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
EP1101759A4 (en) * 1998-07-31 2001-12-12 Nippon Soda Co PHENYLAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICATIONS FOR HYPERLIPEMY
US6420403B1 (en) * 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
GB9914025D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
WO2001046155A1 (en) 1999-12-21 2001-06-28 Icagen, Inc. Potassium channel inhibitors
CA2408913A1 (en) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6620849B2 (en) 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
AU2001277727A1 (en) * 2000-08-10 2002-02-25 Tanabe Seiyaku Co., Ltd. Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof
AU2001277728A1 (en) * 2000-08-10 2002-02-25 Tanabe Seiyaku Co., Ltd. Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
US7375126B2 (en) 2003-06-12 2008-05-20 Abbott Laboratories Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
MXPA06012621A (es) * 2004-05-05 2006-12-15 Hoffmann La Roche Arilsulfonil benzodioxanos utiles para la modulacion del receptor 5-ht6, el receptor 5-ht2a o ambos.
EP2527339A1 (en) * 2004-11-24 2012-11-28 Abbott Laboratories Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
PT1831159E (pt) * 2004-12-21 2010-03-03 Hoffmann La Roche Derivados de tetralina e de indano e as suas utilizações
CA2591800A1 (en) * 2004-12-21 2006-06-29 F.Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof as 5-ht antagonists
BRPI0515835A (pt) * 2004-12-21 2008-08-12 Hoffmann La Roche derivados de tetralina e de indano e seus usos
JP4738418B2 (ja) 2004-12-21 2011-08-03 エフ．ホフマン−ラ ロシュ アーゲー クロマン誘導体及びｃｎｓ障害の処置におけるその使用
ES2306275T3 (es) * 2004-12-21 2008-11-01 F. Hoffmann-La Roche Ag Derivados de cromano y sus usos como ligandos dde receptores 5-ht.
CN1854135B (zh) * 2005-04-18 2013-06-12 李伟章 由氰基胍连接组成的杂环化合物及其医药应用
KR20080064972A (ko) 2005-10-07 2008-07-10 그렌마크 파머수티칼스 에스. 아. 치환된 벤조융합 유도체 및 이의 바닐로이드 수용체리간드로서의 용도
WO2007051735A1 (en) * 2005-11-03 2007-05-10 F. Hoffmann-La Roche Ag Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors
KR20080111144A (ko) * 2006-04-18 2008-12-22 아보트 러보러터리즈 바닐로이드 수용체 서브타입 １(ｖｒ１)의 길항제 및 이의 용도
JP2009541248A (ja) * 2006-06-20 2009-11-26 エフ．ホフマン−ラ ロシュ アーゲー アリールスルホンアミジルテトラリン誘導体及びそれらの使用
WO2007147763A1 (en) * 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
KR101066306B1 (ko) * 2006-06-20 2011-09-20 에프. 호프만-라 로슈 아게 테트랄린 및 인데인 유도체 및 이들의 용도
TW200824687A (en) 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
GB0619176D0 (en) * 2006-09-29 2006-11-08 Lectus Therapeutics Ltd Ion channel modulators & uses thereof
US8030504B2 (en) 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
GB0710844D0 (en) * 2007-06-06 2007-07-18 Lectus Therapeutics Ltd Potassium ion channel modulators & uses thereof
MX2010010262A (es) 2008-03-20 2010-12-06 Abbott Lab Metodos para la elaboracion de agentes para el sistema nervioso central que son antagonistas del trpv1.
RU2597265C2 (ru) * 2010-12-09 2016-09-10 Радикал Терапьютикс Инк. Многофункциональные производные нитроксида и их применение

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5455290A (en) * 1989-05-31 1990-12-06 E.R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
AU7710291A (en) * 1990-06-18 1991-12-19 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
AU1114792A (en) * 1991-02-27 1992-09-03 E.R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
AU5455290A (en) * 1989-05-31 1990-12-06 E.R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
AU7710291A (en) * 1990-06-18 1991-12-19 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
AU1114792A (en) * 1991-02-27 1992-09-03 E.R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives

Also Published As

Publication number Publication date
US5374643A (en) 1994-12-20
EP0587180A3 (OSRAM) 1994-04-20
AU4624093A (en) 1994-03-17
EP0587180A2 (en) 1994-03-16
JPH06293748A (ja) 1994-10-21
CA2105959A1 (en) 1994-03-12

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