AU6658790A - Process for the production of aqueous mixed micelle solutions - Google Patents
Process for the production of aqueous mixed micelle solutionsInfo
- Publication number
- AU6658790A AU6658790A AU66587/90A AU6658790A AU6658790A AU 6658790 A AU6658790 A AU 6658790A AU 66587/90 A AU66587/90 A AU 66587/90A AU 6658790 A AU6658790 A AU 6658790A AU 6658790 A AU6658790 A AU 6658790A
- Authority
- AU
- Australia
- Prior art keywords
- water
- active substances
- solutions containing
- soluble
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Mushroom Cultivation (AREA)
- Colloid Chemistry (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Described is a method of producing aqueous solutions containing mixed micelles formed from lipids and salts of gallic acids and in which active substances insoluble or only slightly soluble in water may, if required, be solubilized. The method is characterized in that mixtures of (a) solutions containing, in a water-soluble organic solvent, the lipids, the free gallic acids and, optionally, the active substances which are insoluble or only slightly soluble in water and (b) solutions containing 0.05-3 equivalents, relative to the gallic acids, of bases and, optionally, isotonizing additives and/or water-soluble active substances are prepared, the organic solvent removed by ultrafiltration, freeze-drying, vacuum distillation or reverse osmosis and the mixture thus obtained diluted, if required, with aqueous phase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3938030 | 1989-11-13 | ||
| DE3938030A DE3938030A1 (en) | 1989-11-13 | 1989-11-13 | METHOD FOR PRODUCING WAITER MIXING MEASUREMENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6658790A true AU6658790A (en) | 1991-05-16 |
| AU648050B2 AU648050B2 (en) | 1994-04-14 |
Family
ID=6393595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU66587/90A Ceased AU648050B2 (en) | 1989-11-13 | 1990-11-13 | Process for the production of aqueous mixed micelle solutions |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0453525B1 (en) |
| JP (1) | JPH04505018A (en) |
| AT (1) | ATE88632T1 (en) |
| AU (1) | AU648050B2 (en) |
| CA (1) | CA2029673C (en) |
| DE (2) | DE3938030A1 (en) |
| DK (1) | DK0453525T3 (en) |
| ES (1) | ES2057592T3 (en) |
| FI (1) | FI913235A0 (en) |
| GR (1) | GR900100798A (en) |
| HU (1) | HUT57577A (en) |
| IE (1) | IE66507B1 (en) |
| NO (1) | NO912748D0 (en) |
| PT (1) | PT95853B (en) |
| WO (1) | WO1991007170A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6663885B1 (en) | 1993-03-15 | 2003-12-16 | A. Natterman & Cie Gmbh | Aqueous liposome system and a method for the preparation of such a liposome system |
| JP2740153B2 (en) * | 1995-03-07 | 1998-04-15 | エフ・ホフマン−ラ ロシユ アーゲー | Mixed micelle |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| WO2008040799A2 (en) * | 2006-10-06 | 2008-04-10 | Boehringer Ingelheim International Gmbh | Process for preparing instant forms of aqueous mixed micellar solutions as physiological buffer systems for use in the analysis of in vitro release |
| EP2201935B1 (en) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1289401A (en) * | 1953-03-07 | 1962-04-06 | Merck & Co Inc | Stabilization process for oily vitamin solutions |
| IT1202370B (en) * | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS |
| EP0252004A1 (en) * | 1986-06-26 | 1988-01-07 | Ciba-Geigy Ag | Pharmaceutical compositions for parenteral application |
| CA1319886C (en) * | 1987-02-03 | 1993-07-06 | Alberto Ferro | Mixed micelle solutions |
-
1989
- 1989-11-13 DE DE3938030A patent/DE3938030A1/en not_active Withdrawn
-
1990
- 1990-10-11 WO PCT/DE1990/000779 patent/WO1991007170A1/en active IP Right Grant
- 1990-10-11 EP EP90915080A patent/EP0453525B1/en not_active Expired - Lifetime
- 1990-10-11 JP JP2513871A patent/JPH04505018A/en active Pending
- 1990-10-11 HU HU907430A patent/HUT57577A/en unknown
- 1990-10-11 DK DK90915080.7T patent/DK0453525T3/en active
- 1990-10-11 ES ES90915080T patent/ES2057592T3/en not_active Expired - Lifetime
- 1990-10-11 DE DE9090915080T patent/DE59001318D1/en not_active Expired - Fee Related
- 1990-10-11 AT AT90915080T patent/ATE88632T1/en not_active IP Right Cessation
- 1990-11-09 CA CA002029673A patent/CA2029673C/en not_active Expired - Fee Related
- 1990-11-09 GR GR900100798A patent/GR900100798A/en not_active IP Right Cessation
- 1990-11-12 PT PT95853A patent/PT95853B/en not_active IP Right Cessation
- 1990-11-13 IE IE408890A patent/IE66507B1/en not_active IP Right Cessation
- 1990-11-13 AU AU66587/90A patent/AU648050B2/en not_active Ceased
-
1991
- 1991-07-03 FI FI913235A patent/FI913235A0/en not_active Application Discontinuation
- 1991-07-12 NO NO912748A patent/NO912748D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU648050B2 (en) | 1994-04-14 |
| DE3938030A1 (en) | 1991-05-16 |
| IE904088A1 (en) | 1991-05-22 |
| JPH04505018A (en) | 1992-09-03 |
| IE66507B1 (en) | 1996-01-10 |
| CA2029673A1 (en) | 1991-05-14 |
| DK0453525T3 (en) | 1993-08-23 |
| FI913235A0 (en) | 1991-07-03 |
| HU907430D0 (en) | 1991-11-28 |
| WO1991007170A1 (en) | 1991-05-30 |
| EP0453525B1 (en) | 1993-04-28 |
| ES2057592T3 (en) | 1994-10-16 |
| PT95853A (en) | 1991-09-13 |
| CA2029673C (en) | 2000-09-19 |
| NO912748L (en) | 1991-07-12 |
| DE59001318D1 (en) | 1993-06-03 |
| GR900100798A (en) | 1992-04-17 |
| EP0453525A1 (en) | 1991-10-30 |
| NO912748D0 (en) | 1991-07-12 |
| PT95853B (en) | 1999-02-26 |
| HUT57577A (en) | 1991-12-30 |
| ATE88632T1 (en) | 1993-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |