PT74701A - Process for the production of lipid membrane structures - Google Patents
Process for the production of lipid membrane structuresInfo
- Publication number
- PT74701A PT74701A PT7470182A PT7470182A PT74701A PT 74701 A PT74701 A PT 74701A PT 7470182 A PT7470182 A PT 7470182A PT 7470182 A PT7470182 A PT 7470182A PT 74701 A PT74701 A PT 74701A
- Authority
- PT
- Portugal
- Prior art keywords
- vesicles
- soln
- mixt
- contg
- lipophilic
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Vesicles are produced by dispersing in an aq. soln. a soln. contg. lipids, amphiphiles, and other lipophilic materials capable of forming vesicles, in a solvent system and subsequently stripping off at least a portion of that system. The system comprises at least two organic components S1 and S2 and (a) S2 is highly soluble in the aq. soln.; (b) S2 is hydrophobic and more volatile than the aq. soln.; (c) the lipophilic material is not entirely soluble in S2 alone; (d) the mixt. of S1 and S2 forms an interface with the aq. soln.; and (e) the lipophilic materials may be dissolved in a mixt. of S1 and S2. The process enables lipid membrane structures i.e. vesicles or liposomes, to be made in an effective, efficient and reproducible manner. The conditions are mild; the vesicles formed trap the aq. phase efficiently and maintain their contents effectively; the vesicle dispersions exhibit good colloidal stability, the vesicles have easily reproducible physical properties, and the method is continuous and easily adaptable to a commercial scale. The process is particularly useful for making vesicles contg. pharmaceutical materials.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT7470182A PT74701B (en) | 1982-04-02 | 1982-04-02 | Process for the production of lipid membrane structures |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT7470182A PT74701B (en) | 1982-04-02 | 1982-04-02 | Process for the production of lipid membrane structures |
Publications (2)
Publication Number | Publication Date |
---|---|
PT74701A true PT74701A (en) | 1982-05-01 |
PT74701B PT74701B (en) | 1983-11-14 |
Family
ID=20083105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT7470182A PT74701B (en) | 1982-04-02 | 1982-04-02 | Process for the production of lipid membrane structures |
Country Status (1)
Country | Link |
---|---|
PT (1) | PT74701B (en) |
-
1982
- 1982-04-02 PT PT7470182A patent/PT74701B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT74701B (en) | 1983-11-14 |
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