AU658822B2 - Hollow fiber cell propagation - Google Patents

Hollow fiber cell propagation

Info

Publication number
AU658822B2
AU658822B2 AU74644/91A AU7464491A AU658822B2 AU 658822 B2 AU658822 B2 AU 658822B2 AU 74644/91 A AU74644/91 A AU 74644/91A AU 7464491 A AU7464491 A AU 7464491A AU 658822 B2 AU658822 B2 AU 658822B2
Authority
AU
Australia
Prior art keywords
bioreactors
hollow fiber
loop
fluids
basal medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU74644/91A
Other languages
English (en)
Other versions
AU7464491A (en
Inventor
Timothy Conrad Gebhard
Uday Kumar Veeramallu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synbiotics LLC
Original Assignee
Synbiotics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synbiotics LLC filed Critical Synbiotics LLC
Publication of AU7464491A publication Critical patent/AU7464491A/en
Application granted granted Critical
Publication of AU658822B2 publication Critical patent/AU658822B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
AU74644/91A 1991-02-12 1991-03-01 Hollow fiber cell propagation Ceased AU658822B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US654034 1991-02-12
US07/654,034 US5656421A (en) 1990-02-15 1991-02-12 Multi-bioreactor hollow fiber cell propagation system and method
PCT/US1991/001386 WO1992013940A1 (en) 1991-02-12 1991-03-01 Hollow fiber cell propagation

Publications (2)

Publication Number Publication Date
AU7464491A AU7464491A (en) 1992-09-07
AU658822B2 true AU658822B2 (en) 1995-05-04

Family

ID=24623210

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74644/91A Ceased AU658822B2 (en) 1991-02-12 1991-03-01 Hollow fiber cell propagation

Country Status (5)

Country Link
US (1) US5656421A (cg-RX-API-DMAC7.html)
EP (1) EP0531297A1 (cg-RX-API-DMAC7.html)
AU (1) AU658822B2 (cg-RX-API-DMAC7.html)
CA (1) CA2080378A1 (cg-RX-API-DMAC7.html)
WO (1) WO1992013940A1 (cg-RX-API-DMAC7.html)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US20020182730A1 (en) * 1995-07-26 2002-12-05 Micheal L. Gruenberg Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
GB9611635D0 (en) * 1996-06-04 1996-08-07 Toja Amsterdam Bv Managing waste effluents etc.
US6029101A (en) * 1996-11-18 2000-02-22 Scius Corporation Process control system user interface
RU2148649C1 (ru) * 1998-03-31 2000-05-10 Институт белка РАН Способ получения полипептидов в бесклеточной системе (варианты) и устройство для его осуществления
US6235196B1 (en) 1998-04-23 2001-05-22 Alliedsignal Inc. Biological wastewater treatment system
US8026096B1 (en) * 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6436288B1 (en) 1999-02-08 2002-08-20 Mississippi State University Bast medium biological reactor treatment system for remediation and odor suppression of organic waste streams
FR2794130B1 (fr) * 1999-05-26 2003-01-03 Bertin Technologies Sa Procede et dispositif de culture de cellules a applications multiples
EP1325110A4 (en) * 2000-10-02 2009-03-25 Thomas F Cannon AUTOMATED BIOCULTURE AND BIOCULTURAL EXPERIENCE SYSTEM
US20020146817A1 (en) * 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
FR2821947B1 (fr) * 2001-03-12 2003-05-16 Canon Kk Procede et dispositif de validation de parametres definissant une image
US20030134341A1 (en) * 2001-09-19 2003-07-17 Medcell Biologics, Llc. Th1 cell adoptive immunotherapy
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20030175272A1 (en) * 2002-03-07 2003-09-18 Medcell Biologics, Inc. Re-activated T-cells for adoptive immunotherapy
JP2009533041A (ja) * 2006-04-12 2009-09-17 シネクサ ライフ サイエンス （ピーティワイ） リミテッド 高性能バイオプロセス装置
WO2007136821A1 (en) 2006-05-22 2007-11-29 Biovest International Inc. Media circulation system for a cell cultureware module
CN101356263B (zh) * 2006-06-26 2013-03-13 泰尔茂比司特公司 培养间充质干细胞的方法
EP2129764B1 (en) * 2007-03-05 2018-10-10 Terumo BCT, Inc. Cell expansion system and methods of use
CA2678893C (en) * 2007-03-05 2015-12-29 Caridianbct, Inc. Methods to control cell movement in hollow fiber bioreactors
KR20100016187A (ko) * 2007-04-06 2010-02-12 카리디안비씨티, 인크. 개선된 생물반응기 표면
EP2148922B1 (en) * 2007-04-13 2020-03-04 Terumo BCT, Inc. Cell expansion system and methods of use
US8852925B2 (en) * 2007-12-17 2014-10-07 The Charlotte-Mecklenburg Hospital Authority Bioreactor for cell growth and associated methods
US8691565B2 (en) 2008-03-05 2014-04-08 Terumo Bct, Inc. Method of reseeding adherent cells grown in a hollow fiber bioreactor system
EP2321403B1 (en) 2008-08-12 2020-07-22 Terumo BCT, Inc. A predictor of when to harvest cells grown in a bioreactor
US20140050943A1 (en) * 2009-03-18 2014-02-20 Oakbio Inc. Multi-Electrode Microbial Fuel Cells and Fuel Cell Systems and Bioreactors with Dynamically Configurable Fluidics
WO2011090605A2 (en) * 2009-12-29 2011-07-28 Caridianbct, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
ES2513643T3 (es) * 2010-01-22 2014-10-27 Lifescan, Inc. Procedimiento y sistema de prueba de analitos
US8940520B2 (en) 2010-05-20 2015-01-27 Pond Biofuels Inc. Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US8889400B2 (en) 2010-05-20 2014-11-18 Pond Biofuels Inc. Diluting exhaust gas being supplied to bioreactor
US11512278B2 (en) 2010-05-20 2022-11-29 Pond Technologies Inc. Biomass production
US8969067B2 (en) 2010-05-20 2015-03-03 Pond Biofuels Inc. Process for growing biomass by modulating supply of gas to reaction zone
US20120156669A1 (en) 2010-05-20 2012-06-21 Pond Biofuels Inc. Biomass Production
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
US20120276633A1 (en) 2011-04-27 2012-11-01 Pond Biofuels Inc. Supplying treated exhaust gases for effecting growth of phototrophic biomass
DK2718416T3 (da) 2011-06-06 2020-02-24 ReGenesys BVBA Ekspansion af stamceller i hulfiberbioreaktorer
WO2012171026A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Methods for high yield virus production
WO2012171030A2 (en) 2011-06-10 2012-12-13 Biovest International, Inc. Method and apparatus for antibody production and purification
EP2885393A1 (en) 2012-08-20 2015-06-24 Terumo BCT, Inc. Method of loading and distributing cells in a bioreactor of a cell expansion system
CA2920957A1 (en) 2012-08-28 2014-03-06 Biovest International, Inc. Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules
US9725768B2 (en) 2012-08-31 2017-08-08 Biovest International, Inc. Methods for producing high-fidelity autologous idiotype vaccines
US9534261B2 (en) 2012-10-24 2017-01-03 Pond Biofuels Inc. Recovering off-gas from photobioreactor
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
WO2015164808A1 (en) 2014-04-24 2015-10-29 Terumo Bct, Inc. Measuring flow rate
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
WO2016167832A1 (en) * 2015-04-16 2016-10-20 Dow Global Technologies Llc Filtration assembly including spiral wound bioreactors and hyperfiltration membrane modules
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656842A1 (en) 2017-03-31 2020-05-27 Terumo BCT, Inc. Cell expansion
CA3160109C (en) 2019-11-20 2023-07-04 Upside Foods, Inc. Apparatuses and systems for preparing a meat product
EP4127130A4 (en) * 2020-04-01 2023-09-20 ADVA Biotechnology Ltd. METHODS AND SYSTEMS FOR VACCINE PRODUCTION
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
US12152699B2 (en) 2022-02-28 2024-11-26 Terumo Bct, Inc. Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
US11981884B2 (en) * 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446747A (en) * 1964-08-11 1969-05-27 Chemical Construction Corp Process and apparatus for reforming hydrocarbons
US3883393A (en) * 1972-05-18 1975-05-13 Us Health Education & Welfare Cell culture on semi-permeable tubular membranes
US4201845A (en) * 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
DE2726313C3 (de) * 1977-06-10 1980-02-07 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin
SE421999B (sv) * 1977-10-17 1982-02-15 Gambro Dialysatoren Anordning for diffusion och/eller filtration av emnen mellan tva fluider via semipermeabla membran vilken anordning innefattar parallellkopplade banor innehallande seriekopplade kamrar
US4220725A (en) * 1978-04-03 1980-09-02 United States Of America Capillary cell culture device
US4764471A (en) * 1984-01-04 1988-08-16 Nabisco Brands, Inc. Continuous bioreactor and process
DE3409501A1 (de) * 1984-03-15 1985-10-24 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur kultivierung von zellen
US4804628A (en) * 1984-10-09 1989-02-14 Endotronics, Inc. Hollow fiber cell culture device and method of operation
JPS6188872A (ja) * 1984-10-09 1986-05-07 Snow Brand Milk Prod Co Ltd 高濃度連続培養方法及び装置
US4680267A (en) * 1985-03-01 1987-07-14 New Brunswick Scientific Company, Inc. Fermentor control system
JPH078231B2 (ja) * 1985-03-25 1995-02-01 株式会社日立製作所 培養制御方法及び培養制御装置
JPS61280270A (ja) * 1985-06-03 1986-12-10 Teijin Ltd 細胞培養装置
US4720462A (en) * 1985-11-05 1988-01-19 Robert Rosenson Culture system for the culture of solid tissue masses and method of using the same
DE3541738A1 (de) * 1985-11-26 1987-05-27 Boehringer Mannheim Gmbh Verfahren und vorrichtung zum kultivieren von zellen
US4853324A (en) * 1985-12-02 1989-08-01 Viles Joseph M Liver assist device employing transformed cell lines
US4889812A (en) * 1986-05-12 1989-12-26 C. D. Medical, Inc. Bioreactor apparatus
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
JPS63230079A (ja) * 1987-03-18 1988-09-26 Toyobo Co Ltd 動物細胞大量培養用通気装置
JPH0695931B2 (ja) * 1987-06-19 1994-11-30 エヌオ−ケ−株式会社 中空糸を用いたバイオリアクタ−
US4861725A (en) * 1988-03-29 1989-08-29 Liau Ming Y Mammalian cell culture apparatus
US4999298A (en) * 1988-04-27 1991-03-12 W. R. Grace & Co.-Conn. Hollow fiber bioreactor culture system and method
US4973558A (en) * 1988-04-28 1990-11-27 Endotronics, Inc. Method of culturing cells using highly gas saturated media
US5126238A (en) * 1990-02-15 1992-06-30 Unisyn Fibertec Corporation Hollow fiber cell propagation system and method
US5202254A (en) * 1990-10-11 1993-04-13 Endotronics, Inc. Process for improving mass transfer in a membrane bioreactor and providing a more homogeneous culture environment

Also Published As

Publication number Publication date
CA2080378A1 (en) 1992-08-13
US5656421A (en) 1997-08-12
WO1992013940A1 (en) 1992-08-20
EP0531297A4 (cg-RX-API-DMAC7.html) 1994-02-16
AU7464491A (en) 1992-09-07
EP0531297A1 (en) 1993-03-17

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