AU6328480A - Method of using motility increasing peptides - Google Patents
Method of using motility increasing peptidesInfo
- Publication number
- AU6328480A AU6328480A AU63284/80A AU6328480A AU6328480A AU 6328480 A AU6328480 A AU 6328480A AU 63284/80 A AU63284/80 A AU 63284/80A AU 6328480 A AU6328480 A AU 6328480A AU 6328480 A AU6328480 A AU 6328480A
- Authority
- AU
- Australia
- Prior art keywords
- denotes
- amino acid
- alpha
- amino
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000004899 motility Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 5
- FUOOLUPWFVMBKG-UHFFFAOYSA-N 2-Aminoisobutyric acid Chemical compound CC(C)(N)C(O)=O FUOOLUPWFVMBKG-UHFFFAOYSA-N 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 4
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 4
- 239000004471 Glycine Substances 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- SCIFESDRCALIIM-UHFFFAOYSA-N N-Me-Phenylalanine Natural products CNC(C(O)=O)CC1=CC=CC=C1 SCIFESDRCALIIM-UHFFFAOYSA-N 0.000 abstract 2
- SCIFESDRCALIIM-VIFPVBQESA-N N-methyl-L-phenylalanine Chemical compound C[NH2+][C@H](C([O-])=O)CC1=CC=CC=C1 SCIFESDRCALIIM-VIFPVBQESA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001414 amino alcohols Chemical class 0.000 abstract 2
- ROLZYTOAMYXLMF-UHFFFAOYSA-N amino(benzyl)carbamic acid Chemical compound OC(=O)N(N)CC1=CC=CC=C1 ROLZYTOAMYXLMF-UHFFFAOYSA-N 0.000 abstract 2
- 150000001555 benzenes Chemical class 0.000 abstract 2
- OWIUPIRUAQMTTK-UHFFFAOYSA-N carbazic acid Chemical compound NNC(O)=O OWIUPIRUAQMTTK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 238000006116 polymerization reaction Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 abstract 2
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
- Polyethers (AREA)
Abstract
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE The peptide of the formula I A-Tyr-B-C-D-E in which A denotes hydrogen, alkyl, alkenyl, or alkenylcycloalkyl each having up to 7 carbon atoms, an alpha-amino acid or a peptide with 2 or 3 amino acids, preferably of the L-configuration, B denotes an alpha-amino acid or alpha-amino-isobutyric acid, C denotes glycine or azaglycine, D denotes phenylalanine which can be substituted in the benzene nucleus by methyl, methoxy, halogen, nitro or trifluoromethyl, dehydro- or hexahydrophenylalanine, aza- or N-methylphenylalanine, and E denotes (a) -O-R1 R1 denotes a methyl-polyethylene glycol radical having a degree of polymerization of up to about 50, (b) an amino alcohol or an amino acid, which on its part may carry one of the groups defined sub (a). 1. Claims for the Contracting State : AT A process for the preparation of a peptide of the formula I A-Tyr-B-C-D-E in which A denotes hydrogen, alkyl, alkenyl, or alkenylcycloalkyl each having up to 7 carbon atoms, an alpha-amino acid or a peptide with 2 or 3 amino acids, preferably of the L-configuration, B denotes an alpha-amino acid or alpha-amino-isobutyric acid, C denotes glycine or azaglycine, D denotes phenylalanine which can be substituted in the benzene nucleus by methyl, methoxy, halogen, nitro or trifluormethyl, dehydro- or hexahydrophenylalanine, aza- or N-methylphenylalanine, and E denotes a) -O-R1 R1 denotes a methyl-polyethylene glycol radical having a degree of polymerization of up to about 50, b) an amino alcohol or an amino acid, which on its part may carry one of the groups defined sub (a), characterized in that the amino acid sequences of the formula I are prepared by methods of peptide synthesis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29417901 | 1979-10-16 | ||
| DE19792941790 DE2941790A1 (en) | 1979-10-16 | 1979-10-16 | USE OF MOTIVITY-INCREASING PEPTIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6328480A true AU6328480A (en) | 1981-04-30 |
| AU541547B2 AU541547B2 (en) | 1985-01-10 |
Family
ID=6083575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU63284/80A Ceased AU541547B2 (en) | 1979-10-16 | 1980-10-15 | Method of using motility increasing peptides |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0028716B1 (en) |
| JP (1) | JPS5668617A (en) |
| AT (1) | ATE23441T1 (en) |
| AU (1) | AU541547B2 (en) |
| CA (1) | CA1177401A (en) |
| DE (2) | DE2941790A1 (en) |
| ZA (1) | ZA806328B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU185640B (en) * | 1980-07-17 | 1985-03-28 | Sandoz Ag | Process for producing new pentapeptides |
| DE3163199D1 (en) * | 1980-07-17 | 1984-05-24 | Sandoz Ag | Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use |
| ATE16495T1 (en) * | 1981-06-22 | 1985-11-15 | Ici Plc | PEPTIDES AND PSEUDOPEPTIDES HAVING TWO SUBSTITUENTS AT THE N-TERMINUS. |
| SU1348343A1 (en) * | 1984-07-16 | 1987-10-30 | Всесоюзный кардиологический научный центр АМН СССР | Hexapeptide possessing antipancreatonecrotic activity |
| SU1470739A1 (en) * | 1984-07-16 | 1989-04-07 | Всесоюзный кардиологический научный центр АМН СССР | Hexapeptide displaying hepatoprotective traits |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2730851A1 (en) * | 1976-07-19 | 1978-01-26 | Sandoz Ag | NEW POLYPEPTIDE DERIVATIVES, THEIR PRODUCTION AND USE |
| DK386677A (en) * | 1976-09-01 | 1978-03-02 | D H Y | METHIONINENCEPHALIN DERIVATIVES THEIR MANUFACTURE AND USE INTERMEDIATE PRODUCTS |
-
1979
- 1979-10-16 DE DE19792941790 patent/DE2941790A1/en not_active Withdrawn
-
1980
- 1980-10-11 DE DE8080106211T patent/DE3071825D1/en not_active Expired
- 1980-10-11 EP EP80106211A patent/EP0028716B1/en not_active Expired
- 1980-10-11 AT AT80106211T patent/ATE23441T1/en not_active IP Right Cessation
- 1980-10-15 ZA ZA00806328A patent/ZA806328B/en unknown
- 1980-10-15 AU AU63284/80A patent/AU541547B2/en not_active Ceased
- 1980-10-15 CA CA000362430A patent/CA1177401A/en not_active Expired
- 1980-10-16 JP JP14373680A patent/JPS5668617A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0028716A3 (en) | 1981-12-23 |
| ATE23441T1 (en) | 1986-11-15 |
| DE2941790A1 (en) | 1981-04-30 |
| CA1177401A (en) | 1984-11-06 |
| DE3071825D1 (en) | 1987-01-02 |
| JPS5668617A (en) | 1981-06-09 |
| ZA806328B (en) | 1981-10-28 |
| AU541547B2 (en) | 1985-01-10 |
| EP0028716A2 (en) | 1981-05-20 |
| EP0028716B1 (en) | 1986-11-12 |
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