AU626255B2 - Factor viii binding domain of von willebrand factor - Google Patents

Factor viii binding domain of von willebrand factor Download PDF

Info

Publication number
AU626255B2
AU626255B2 AU15271/88A AU1527188A AU626255B2 AU 626255 B2 AU626255 B2 AU 626255B2 AU 15271/88 A AU15271/88 A AU 15271/88A AU 1527188 A AU1527188 A AU 1527188A AU 626255 B2 AU626255 B2 AU 626255B2
Authority
AU
Australia
Prior art keywords
factor viii
polypeptide
amino acid
factor
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU15271/88A
Other languages
English (en)
Other versions
AU1527188A (en
Inventor
Paul A. Foster
Carol A. Fulcher
Theodore S. Zimmerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of AU1527188A publication Critical patent/AU1527188A/en
Application granted granted Critical
Publication of AU626255B2 publication Critical patent/AU626255B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU15271/88A 1987-05-01 1988-04-28 Factor viii binding domain of von willebrand factor Expired AU626255B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07045032 US5043429B1 (en) 1987-05-01 1987-05-01 Protein fragments containing factor VIII binding domain of von willebrand factor
US045032 1987-05-01

Publications (2)

Publication Number Publication Date
AU1527188A AU1527188A (en) 1988-11-03
AU626255B2 true AU626255B2 (en) 1992-07-30

Family

ID=21935641

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15271/88A Expired AU626255B2 (en) 1987-05-01 1988-04-28 Factor viii binding domain of von willebrand factor

Country Status (9)

Country Link
US (3) US5043429B1 (fr)
EP (1) EP0294025B1 (fr)
JP (1) JP2631127B2 (fr)
AT (1) ATE133183T1 (fr)
AU (1) AU626255B2 (fr)
CA (1) CA1341097C (fr)
DE (1) DE3854904T2 (fr)
ES (1) ES2081804T3 (fr)
GR (1) GR3018870T3 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5530100A (en) * 1990-05-07 1996-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods for purification of recombinantly produced proteins
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5847086A (en) * 1991-06-20 1998-12-08 Centeon L.L.C. Therapeutic fragments of von Willebrand factor
EP0590048B1 (fr) * 1991-06-20 2004-12-01 Aventis Behring L.L.C. Un procede pour preparer des fragments therapeutiques du facteur de von willebrand
CA2117780A1 (fr) * 1992-04-10 1993-10-28 Paul F. Goetinck Proteine structurale de cartilage et modes d'emploi
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
DE19740310A1 (de) * 1997-09-13 1999-04-01 Octapharma Ag Peptid mit Affinität zu Gerinnungsfaktor VIII
KR100398058B1 (ko) * 2001-05-18 2003-09-19 주식회사 경동도시가스 수식된 θ-알루미나에 담지되어 이루어진 니켈계 개질촉매및 이를 이용한 천연가스로부터 합성가스의 제조방법
JP2008512098A (ja) * 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
WO2006029258A2 (fr) * 2004-09-07 2006-03-16 Archemix Corp. Chimie medicale utilisant des aptameres
WO2008150495A2 (fr) * 2007-06-01 2008-12-11 Archemix Corp. Formulations d'aptamère vwf et procédés d'utilisation
CA2780542C (fr) 2009-11-13 2020-03-24 Grifols Therapeutics Inc. Preparations contenant le facteur de von willebrand (vwf) et procedes, coffrets et utilisations s'y rapportant
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
WO2013093760A2 (fr) 2011-12-19 2013-06-27 Grifols, S.A. Compositions, procédés et trousses pour la préparation de protéines recombinantes sialylées
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
EP3476937A4 (fr) 2016-06-24 2019-12-04 Mogam Institute for Biomedical Research Protéine chimère comprenant les facteurs fviii et vwf, et utilisation de celle-ci
US11999797B2 (en) 2018-02-06 2024-06-04 Ablynx N.V. Methods of treating initial episode of TTP with immunoglobulin single variable domains

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
JP2525022B2 (ja) * 1986-01-03 1996-08-14 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド ▲ＶＩＩＩ▼：ｃ因子型タンパク質の改良生産方法
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor

Also Published As

Publication number Publication date
DE3854904T2 (de) 1996-07-04
AU1527188A (en) 1988-11-03
DE3854904D1 (de) 1996-02-29
JPS6456697A (en) 1989-03-03
US5260274A (en) 1993-11-09
US5043429A (en) 1991-08-27
EP0294025A3 (en) 1989-11-08
ES2081804T3 (es) 1996-03-16
JP2631127B2 (ja) 1997-07-16
US5043429B1 (en) 1997-10-14
US5597711A (en) 1997-01-28
US5260274B1 (en) 1998-01-20
GR3018870T3 (en) 1996-05-31
EP0294025B1 (fr) 1996-01-17
CA1341097C (fr) 2000-09-12
ATE133183T1 (de) 1996-02-15
EP0294025A2 (fr) 1988-12-07

Similar Documents

Publication Publication Date Title
AU626255B2 (en) Factor viii binding domain of von willebrand factor
US4877614A (en) Biologically active fragments of human antihemophilic factor and method for preparation thereof
AU780775B2 (en) Factor IX/factor IXa antibodies and antibody derivatives
Fass et al. Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein
AU665752B2 (en) Recombinant thrombin receptor and related pharmaceuticals
US7910094B2 (en) Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
US8586538B2 (en) Method of treating a patient suffering from a bleeding disorder comprising administering an antibody against the A3-C1 of FVIII
CA1341506C (fr) Polypeptides coagulants analogues au facteur viii ainsi que des anticorps monoclonaux que leur sont specifiques
KR940002033B1 (ko) 단백질 c에 대해 특이성이 있는 단클론성 항체 및 항체의 분리방법
EP0182372A2 (fr) Polypeptides facteur VIII coagulant
EP0319315A2 (fr) Domaine du facteur VIII liant le facteur de von Willebrand
EP0972781B1 (fr) Polypeptides de la protéine S et leurs utilisations
EP0640100A1 (fr) Modulation des interactions entre cd36 et la thrombospondine
EP0317279A2 (fr) Peptides pour l'usage dans la purification du facteur-VIII
EP1399556B1 (fr) Epitopes antigenes du factor viii, inhibiteurs diriges contre ces epitopes et leur utilisation
JPH10179159A (ja) モノクローナル抗体、免疫吸着剤としての使用およびヒトプラスミノーゲンの製造方法
JPH06205696A (ja) 非天然型ヒト凝固第ｖｉｉｉ因子ｌ鎖結合性モノクローナル抗体