AU544256B2 - Novel acylpeptides - Google Patents

Novel acylpeptides

Info

Publication number
AU544256B2
AU544256B2 AU65345/80A AU6534580A AU544256B2 AU 544256 B2 AU544256 B2 AU 544256B2 AU 65345/80 A AU65345/80 A AU 65345/80A AU 6534580 A AU6534580 A AU 6534580A AU 544256 B2 AU544256 B2 AU 544256B2
Authority
AU
Australia
Prior art keywords
amino acids
amino group
acylpeptides
epsilon
lysine residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
AU65345/80A
Other languages
English (en)
Other versions
AU6534580A (en
Inventor
Bruno Kamber
Hans Rink
Peter Sieber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU6534580A publication Critical patent/AU6534580A/en
Application granted granted Critical
Publication of AU544256B2 publication Critical patent/AU544256B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU65345/80A 1979-12-14 1980-12-12 Novel acylpeptides Expired - Fee Related AU544256B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1109679 1979-12-14
CH11096/79 1979-12-14

Publications (2)

Publication Number Publication Date
AU6534580A AU6534580A (en) 1981-06-18
AU544256B2 true AU544256B2 (en) 1985-05-23

Family

ID=4370005

Family Applications (1)

Application Number Title Priority Date Filing Date
AU65345/80A Expired - Fee Related AU544256B2 (en) 1979-12-14 1980-12-12 Novel acylpeptides

Country Status (18)

Country Link
US (1) US4369179A (Direct)
EP (1) EP0030920B1 (Direct)
JP (1) JPS5692850A (Direct)
KR (2) KR850000415B1 (Direct)
AT (1) ATE6251T1 (Direct)
AU (1) AU544256B2 (Direct)
CA (1) CA1161033A (Direct)
DD (1) DD154098A5 (Direct)
DE (1) DE3066654D1 (Direct)
DK (1) DK532180A (Direct)
ES (1) ES8200861A1 (Direct)
FI (1) FI803849A7 (Direct)
GR (1) GR73621B (Direct)
IL (1) IL61696A0 (Direct)
NO (1) NO803757L (Direct)
NZ (1) NZ195817A (Direct)
PT (1) PT72191B (Direct)
ZA (1) ZA807796B (Direct)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE14226T1 (de) * 1981-12-24 1985-07-15 Ciba Geigy Ag Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
FR2522655B1 (fr) * 1982-03-05 1987-03-06 Sanofi Sa Analogues de la somatostatine possedant une liaison du type hydrazide et medicaments en contenant
DE3379657D1 (en) * 1982-12-06 1989-05-24 Merck & Co Inc Dicyclic hexapeptides, processes for their preparation and pharmaceutical compositions containing them
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
JP2882679B2 (ja) * 1989-04-26 1999-04-12 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 線状ソマトスタチン類似体
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0981364B1 (en) * 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Method and compositions for treating hyperlipidemia
CA2290592A1 (en) * 1997-05-13 1998-11-19 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
CA2289499C (en) * 1997-05-13 2010-02-23 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
EP1305338A2 (en) * 2000-08-02 2003-05-02 Theratechnologies Inc. Modified peptides with increased potency
NZ530007A (en) 2001-06-08 2006-02-24 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
CA2523197C (en) 2003-04-22 2016-05-24 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Peptide vectors
WO2009150470A2 (en) 2008-06-12 2009-12-17 Syntaxin Limited Suppression of cancers
EP2310028B1 (en) 2008-06-12 2016-11-16 Ipsen Bioinnovation Limited Fusion proteins for use in the treatment of acromegaly
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
EP3007704B1 (en) 2013-06-13 2021-01-06 Antisense Therapeutics Ltd Combination therapy for acromegaly

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3944590A (en) * 1967-01-25 1976-03-16 Ciba-Geigy Corporation Process for the temporary protection of amino groups in peptide syntheses
US3875207A (en) * 1967-01-25 1975-04-01 Ciba Geigy Corp Process for the temporary protection of amino groups in peptide syntheses
US3725380A (en) * 1969-04-05 1973-04-03 Hoechst Ag Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
CH517705A (de) * 1969-12-16 1972-01-15 Ciba Geigy Ag Verfahren zur Herstellung von Cystin-haltigen Peptiden
DE2202613C3 (de) * 1972-01-20 1974-06-20 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Peptiden
CH577464A5 (Direct) * 1972-09-22 1976-07-15 Ciba Geigy Ag
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
US4113714A (en) * 1975-01-03 1978-09-12 American Home Products Corporation [Des-Ala1, Gly2 -desamino-Cys3 ]somatostatin
US4130554A (en) * 1975-04-08 1978-12-19 Merck & Co., Inc. Process for preparing somatostatin analog
US4000259A (en) * 1975-06-16 1976-12-28 American Home Products Corporation Cyclic dodecapeptide analogs of somatostatin and intermediates
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
CA1083143A (en) * 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor
US4062816A (en) * 1976-03-11 1977-12-13 Eli Lilly And Company D-Ala5 -somatostatin and intermediates thereto
US4098782A (en) * 1977-03-14 1978-07-04 American Home Products Corporation (His5)-somatostatin and analogues thereof
US4118380A (en) * 1977-07-25 1978-10-03 Ayerst, Mckenna & Harrison Limited Decapeptide analogs of somatostatin
US4115554A (en) * 1977-08-29 1978-09-19 Merck & Co., Inc. Somatostatin analogs
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4202802A (en) * 1978-10-02 1980-05-13 Eli Lilly And Company Peptides related to somatostatin
US4191754A (en) * 1979-02-28 1980-03-04 Merck & Co., Inc. Bicyclic somatostatin analogs
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs

Also Published As

Publication number Publication date
AU6534580A (en) 1981-06-18
KR830004216A (ko) 1983-07-06
DE3066654D1 (en) 1984-03-22
JPS5692850A (en) 1981-07-27
ES497696A0 (es) 1981-11-16
IL61696A0 (en) 1981-01-30
ZA807796B (en) 1982-01-27
EP0030920A3 (en) 1981-11-04
FI803849L (fi) 1981-06-15
KR850000414B1 (ko) 1985-03-26
DK532180A (da) 1981-06-15
FI803849A7 (fi) 1981-06-15
GR73621B (Direct) 1984-03-26
CA1161033A (en) 1984-01-24
PT72191A (de) 1981-01-01
NO803757L (no) 1981-06-15
ES8200861A1 (es) 1981-11-16
NZ195817A (en) 1984-07-06
EP0030920B1 (de) 1984-02-15
US4369179A (en) 1983-01-18
DD154098A5 (de) 1982-02-24
PT72191B (de) 1982-01-13
ATE6251T1 (de) 1984-03-15
EP0030920A2 (de) 1981-06-24
KR850000415B1 (ko) 1985-03-26

Similar Documents

Publication Publication Date Title
AU6534580A (en) Novel acylpeptides
HU902697D0 (en) Process for the enzymatic removal of the n-terminal sequence of proteins
IE801342L (en) Peptides
IL85020A (en) Pancreatic secretory trypsin inhibitor variants, their production, expression vectors and recombinant hosts therefor and pharmaceutical compositions containing them
GR81710B (Direct)
AU575843B2 (en) Growth hormone releasing peptides
PT73291A (en) Process for the preparation of novel peptides
IE801341L (en) Immunostimulant dipeptides
DE3160757D1 (en) Amino acid and peptide esters of leuco-indo anilines, process for their preparation and agents containing these compounds for the detection of proteolytic enzymes
EP0330700A4 (en) Human prourokinase-like polypeptide.
JPS55115851A (en) Recovery of amino acid from protein hydrolyzate
DE3751398D1 (de) Substrat-Peptide.
EP0294667A3 (en) (2-cyano-2-oximinoacetyl)-amino acid derivatives
IL64790A (en) Process for the preparation of compounds containing carboxylic acid amide groups,in particular of peptides
DE3886443D1 (de) Menschliche Rhinoviruspeptide.
AU542310B2 (en) Glicentin related purified peptide having 30 amino acids
GB1379937A (en) Preparation of lysine-containing peptides
EP0292302A3 (en) Human splenin
JPS52128291A (en) Synthesis of peptides
FR2401906A1 (fr) Nouveaux sels de paracetamol solubles dans l'eau utiles comme medicaments
JPS5283738A (en) Novel dipeptide derivatives and their salts
GB910860A (en) Method of crystallizing optically active glutamic acid
DE3271909D1 (en) Antigenic linear peptide compounds
JPS51136602A (en) Process for preparation of amino acid or peptide