AU5209699A - Synthesis of compounds useful in the manufacture of ketorolac - Google Patents

Synthesis of compounds useful in the manufacture of ketorolac

Info

Publication number
AU5209699A
AU5209699A AU52096/99A AU5209699A AU5209699A AU 5209699 A AU5209699 A AU 5209699A AU 52096/99 A AU52096/99 A AU 52096/99A AU 5209699 A AU5209699 A AU 5209699A AU 5209699 A AU5209699 A AU 5209699A
Authority
AU
Australia
Prior art keywords
ketorolac
synthesis
manufacture
compounds useful
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU52096/99A
Other languages
English (en)
Inventor
Henry J. Buehler
Douglas C. Caskey
John R. Duchek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of AU5209699A publication Critical patent/AU5209699A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU52096/99A 1998-07-10 1999-07-08 Synthesis of compounds useful in the manufacture of ketorolac Abandoned AU5209699A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9240898P 1998-07-10 1998-07-10
US60092408 1998-07-10
PCT/US1999/015496 WO2000002855A2 (en) 1998-07-10 1999-07-08 Synthesis of compounds useful in the manufacture of ketorolac

Publications (1)

Publication Number Publication Date
AU5209699A true AU5209699A (en) 2000-02-01

Family

ID=22233070

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52096/99A Abandoned AU5209699A (en) 1998-07-10 1999-07-08 Synthesis of compounds useful in the manufacture of ketorolac

Country Status (8)

Country Link
US (3) US6376681B1 (enExample)
EP (1) EP1097152B1 (enExample)
JP (1) JP2002520313A (enExample)
AT (1) ATE323703T1 (enExample)
AU (1) AU5209699A (enExample)
DE (1) DE69930940T2 (enExample)
ES (1) ES2259475T3 (enExample)
WO (1) WO2000002855A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070906A1 (en) * 1999-11-30 2005-03-31 Ron Clark Endosteal tibial ligament fixation with adjustable tensioning
GB0000569D0 (en) 2000-01-12 2000-03-01 Ici Plc Organometallic compositions
GB0112901D0 (en) 2001-05-29 2001-07-18 Ici Plc Organometallic compositions
US7341502B2 (en) * 2002-07-18 2008-03-11 Micron Technology, Inc. Methods and systems for planarizing workpieces, e.g., microelectronic workpieces
LU91605B1 (fr) 2009-09-07 2011-03-08 Terra Nobilis S A Procédé de sécurisation du stockage de déchets radioactifs de longue vie.
CN113087619A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体化合物
CN113087626A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体化合物ⅵ
CN113087710A (zh) * 2020-01-09 2021-07-09 鲁南制药集团股份有限公司 一种酮咯酸氨丁三醇中间体的制备方法
CN112898307A (zh) * 2021-02-07 2021-06-04 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种酮咯酸杂质c及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
CH616808B (fr) * 1978-06-14 Piquerez Sa Ervin Procede de fabrication d'une boite de montre et boite de montre obtenue par ce procede.
US4458081A (en) * 1980-10-20 1984-07-03 Syntex (U.S.A.) Inc. 5-Aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-decarboxylates
US5082951A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor
KR0140134B1 (ko) * 1994-11-16 1998-06-01 강재헌 피롤리진 유도체의 제조방법

Also Published As

Publication number Publication date
ES2259475T3 (es) 2006-10-01
US20030036660A1 (en) 2003-02-20
JP2002520313A (ja) 2002-07-09
DE69930940T2 (de) 2006-12-14
US6489491B2 (en) 2002-12-03
ATE323703T1 (de) 2006-05-15
US6376681B1 (en) 2002-04-23
WO2000002855A2 (en) 2000-01-20
US20020137945A1 (en) 2002-09-26
US6559319B2 (en) 2003-05-06
EP1097152B1 (en) 2006-04-19
EP1097152A2 (en) 2001-05-09
WO2000002855A3 (en) 2000-02-24
DE69930940D1 (de) 2006-05-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase