AU516479B2 - Process for preparing 3-isobutoxy 2-pyrrolidino n-phenyl n-benzyl propylamine - Google Patents

Process for preparing 3-isobutoxy 2-pyrrolidino n-phenyl n-benzyl propylamine

Info

Publication number
AU516479B2
AU516479B2 AU32660/78A AU3266078A AU516479B2 AU 516479 B2 AU516479 B2 AU 516479B2 AU 32660/78 A AU32660/78 A AU 32660/78A AU 3266078 A AU3266078 A AU 3266078A AU 516479 B2 AU516479 B2 AU 516479B2
Authority
AU
Australia
Prior art keywords
pyrrolidino
isobutoxy
phenyl
preparing
propylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU32660/78A
Other languages
English (en)
Other versions
AU3266078A (en
Inventor
R-J Busch N Symond J Montell A and Moleyns J Mauvernay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CENTRE EUTOPEEN DE RECHERCHES MAUVERNAY
Original Assignee
EUTOPEEN DE RECH MAUVERNAY CEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EUTOPEEN DE RECH MAUVERNAY CEN filed Critical EUTOPEEN DE RECH MAUVERNAY CEN
Publication of AU3266078A publication Critical patent/AU3266078A/en
Application granted granted Critical
Publication of AU516479B2 publication Critical patent/AU516479B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU32660/78A 1977-01-25 1978-01-23 Process for preparing 3-isobutoxy 2-pyrrolidino n-phenyl n-benzyl propylamine Expired AU516479B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FRFR7702058 1977-01-25
FR7702058A FR2378024A1 (fr) 1977-01-25 1977-01-25 Nouvelle propylamine substituee, obtention et application

Publications (2)

Publication Number Publication Date
AU3266078A AU3266078A (en) 1979-08-02
AU516479B2 true AU516479B2 (en) 1981-06-04

Family

ID=9185890

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32660/78A Expired AU516479B2 (en) 1977-01-25 1978-01-23 Process for preparing 3-isobutoxy 2-pyrrolidino n-phenyl n-benzyl propylamine

Country Status (12)

Country Link
JP (1) JPS5392764A (fr)
AU (1) AU516479B2 (fr)
BE (1) BE863214A (fr)
CH (1) CH628889A5 (fr)
DE (1) DE2802864C2 (fr)
ES (1) ES466237A1 (fr)
FR (1) FR2378024A1 (fr)
GB (1) GB1595031A (fr)
IL (1) IL53816A0 (fr)
NL (1) NL189258C (fr)
PT (1) PT67556B (fr)
ZA (1) ZA78426B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002274A1 (fr) * 1981-12-28 1983-07-07 Carter Wallace Synthese de l'hydrochlorure de 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolydino
DK156396C (da) * 1983-09-27 1990-01-08 Cerm Cent Europ Rech Mauvernay 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
DE3468684D1 (de) * 1983-11-11 1988-02-18 Akzo Nv Ether of n-propanolamine derivative
FR2558161B1 (fr) * 1984-01-18 1987-01-23 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino) n-furylmethyl ou n-thienylmethyl n-pyridyl propylamines, leur preparation et leur application en therapeutique
FR2558160B1 (fr) * 1984-01-18 1986-05-30 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyrimidinyl ou -pyrazinyl propylamines, leur preparation et leur application en therapeutique
FR2558159B1 (fr) * 1984-01-18 1986-06-13 Cerm Cent Europ Rech Mauvernay 3-alkoxy 2-(n-pyrrolidino)-n-pyridyl-n-arylmethyl-propylamines, leur preparation et leur application en therapeutique
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JP2678758B2 (ja) * 1988-02-16 1997-11-17 興和株式会社 新規なプロパン誘導体
WO2016098128A1 (fr) * 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Procédé de préparation de bépridil

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795735A (fr) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay Nouvelles ethylenediamines substituees a activite cardiovasculaire

Also Published As

Publication number Publication date
PT67556A (fr) 1978-02-01
NL7800753A (nl) 1978-07-27
FR2378024A1 (fr) 1978-08-18
NL189258C (nl) 1993-02-16
IL53816A0 (en) 1978-04-30
ZA78426B (en) 1979-01-31
AU3266078A (en) 1979-08-02
DE2802864C2 (de) 1982-12-09
GB1595031A (en) 1981-08-05
FR2378024B1 (fr) 1979-05-11
JPS5429493B2 (fr) 1979-09-25
NL189258B (nl) 1992-09-16
JPS5392764A (en) 1978-08-15
ES466237A1 (es) 1978-10-16
PT67556B (fr) 1979-06-18
DE2802864A1 (de) 1978-07-27
CH628889A5 (en) 1982-03-31
BE863214A (fr) 1978-07-24

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